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Best treatments for heart failure

72 products may treat heart failure, spanning FDA drug classes such as angiotensin 2 receptor blocker, recombinant human growth hormone, loop diuretic. The current highest-rated option is atacand. Ranked below by our independent recall-safety rating (rated where FDA data exists) — not medical advice; always consult a professional.

Quick answer: Of the 72 drugs we list for heart failure, 52 are available as lower-cost generics, spanning classes such as angiotensin 2 receptor blocker, recombinant human growth hormone, loop diuretic. 29 of 72 carry a safety score, from 58 to 72 out of 100. They’re ranked by each drug’s FDA recall-safety record — not clinical effectiveness for heart failure — so confirm the right choice with your prescriber.

Rated against independent regulatory sources·Last updated October 11, 2026·How we rate

Understanding heart failure

Heart failure (sometimes called congestive heart failure) is a long-term condition in which the heart cannot pump enough blood to meet the body's needs. It does not mean the heart has stopped. According to the NHLBI, more than 6 million U.S. adults have heart failure. It usually develops when another condition damages or overworks the heart, such as coronary heart disease, high blood pressure, heart inflammation, cardiomyopathy, or an irregular heartbeat. Common symptoms include shortness of breath, fatigue, and fluid buildup that causes swelling in the lower body or around the abdomen. Heart failure is often described by ejection fraction, either reduced (HFrEF) or preserved (HFpEF), which helps guide treatment. There is no cure, but per NHLBI and MedlinePlus, treatment can help many people live longer and feel better. Management combines heart-healthy lifestyle changes (lowering sodium, staying active as advised, quitting smoking, limiting alcohol, and controlling blood pressure and other risk factors) with medicines, and in some cases devices such as pacemakers or defibrillators. This is general information, not medical advice; treatment should be individualized by a licensed healthcare professional.

First-line treatment

For heart failure with reduced ejection fraction (HFrEF), the 2022 AHA/ACC/HFSA guideline recommends foundational, guideline-directed medical therapy built on four medication classes: a renin-angiotensin system inhibitor, a beta-blocker, a mineralocorticoid receptor antagonist (MRA), and an SGLT2 inhibitor. Among renin-angiotensin system inhibitors, an angiotensin receptor-neprilysin inhibitor (ARNI) is recommended as first-line, with an ACE inhibitor used when an ARNI is not feasible and an ARB when an ACE inhibitor is not tolerated. SGLT2 inhibitors are recommended in symptomatic chronic HFrEF regardless of whether the person has type 2 diabetes, and may also benefit preserved ejection fraction (HFpEF). Diuretics are commonly used to relieve fluid buildup and symptoms; a clinician determines the specific medicines and sets and adjusts all dosing.

Top-rated picks for heart failure: 1. Atacand · 2. Bio-Tropin · 3. Bumex

Top-rated treatments for heart failure, ranked by pharmaranks score
#DrugRatingPharmacy pays
172/100$16View →
272/100—View →
372/100$4View →
472/100$0View →
572/100$1View →
672/100$2View →
772/100$2View →
872/100$1View →
972/100$0View →
1072/100$2View →

Full ranking · 72 treatments

#1 of 8 in Angiotensin 2 Receptor Blocker

atacand

Boxed warning

PrescriptionFDA-sourced

72/100

Atacand (Candesartan Cilexetil) is an angiotensin 2 receptor blocker used to treat Diabetic Nephropathies, Heart Failure, Hypertension, Left Ventricular Dysfunction.

(13 data points)
angiotensin 2 receptor blockerdiabetic nephropathiesheart failure

Pharmacy pays

From ~$14.41/30· 4 forms Save up to 94% in class
View details →
#1 of 13 in Recombinant Human Growth Hormone

bio-tropin

PrescriptionFDA-sourced

72/100

Bio-Tropin (Somatropin) is a recombinant human growth hormone used to treat Cachexia, Dwarfism, Heart Failure, Noonan Syndrome.

(12 data points)
recombinant human growth hormonecachexiadwarfism

Price varies

View details →

bumex

Boxed warning

PrescriptionFDA-sourced

72/100

Bumex (Bumetanide) is a loop diuretic used to treat Ascites, Edema, Heart Failure, Hypertension.

(2 data points)
loop diureticascitesedema

Pharmacy pays

From ~$3.35/30· 3 forms Save up to 46% in class
View details →
#1 of 11 in Angiotensin Converting Enzyme Inhibitor

epaned

Boxed warning

PrescriptionFDA-sourced

72/100

Epaned (Enalapril Maleate) is an angiotensin converting enzyme inhibitor used to treat Rheumatoid Arthritis, Bartter Syndrome, Diabetic Nephropathies, Edema.

(4 data points)
angiotensin converting enzyme inhibitorarthritis, rheumatoidbartter syndrome

Pharmacy pays

From ~$0.07· 5 forms
View details →
#1 of 4 in Thiazide Diuretic

hydrochlorothiazide

PrescriptionFDA-sourced

72/100

Hydrochlorothiazide is a thiazide diuretic used to treat Edema, Heart Failure, Hypertension, Nephrotic Syndrome.

(11 data points)
thiazide diureticedemaheart failure

Pharmacy pays

From ~$0.36/30· 4 forms
View details →
#1 of 11 in beta-Adrenergic Blocker

inderal la

PrescriptionFDA-sourced

72/100

Inderal La (Propranolol Hydrochloride) is a beta-adrenergic blocker used to treat Angina Pectoris, Esophageal and Gastric Varices, Heart Failure, Hypertension.

(13 data points)
beta-adrenergic blockerangina pectorisesophageal and gastric varices

Pharmacy pays

From ~$1.51/30· 8 forms Save up to 76% in class
View details →

Frequently asked

What treats heart failure?
Our catalog lists 72 products that may treat heart failure, based on NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. They're rated where FDA recall-safety data exists; the current top-rated option is atacand.
What is the best-rated treatment for heart failure?
By our independent recall-safety rating — not an efficacy measure — atacand ranks highest among the products we list for heart failure. Always consult a professional.
How are these treatments ranked?
By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.
What types of drugs treat heart failure?
Treatments for heart failure span FDA drug classes including angiotensin 2 receptor blocker, recombinant human growth hormone, loop diuretic, angiotensin converting enzyme inhibitor, thiazide diuretic. Compare every option side by side, ranked by independent rating, above.

Treatment associations are derived from NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. This is general reference, not medical advice — always consult a licensed professional.

Sources

The clinical overview above is written from these authoritative public-health and medical-society sources, independently reviewed against each.