thalitone
Thalitone (Chlorthalidone) is a thiazide-like diuretic used to treat Edema, Glomerulonephritis, Heart Failure, Hypertension.
Chlorthalidone · by Casper Pharma LLC
Available as a generic: Chlorthalidone
Key facts
- Active ingredient
- Chlorthalidone
- Drug class
- Thiazide-Like Diuretic
- Form
- Tablet
- Strength
- Chlorthalidone 15MG · Chlorthalidone 25MG
- Type
- Prescription (Rx)
- Brand or generic
- Brand-name
- May treat
- edema, glomerulonephritis, heart failure
- Manufacturer
- Casper Pharma LLC
- Half-life
- about 40 hours on average (the label reports a mean half-life of 40 hours after a 50–200 mg dose, and an elimination half-life of 53 hours after 50 mg and 60 hours after 100 mg) (how long it stays in your system)
- What the pharmacy pays
- ~$2.67 for 30 — not your price
- FDA application
- NDA019574
What is Thalitone?
From the FDA label:THALITONE (chlorthalidone USP) is an antihypertensive/diuretic supplied as 15 mg and 25 mg tablets for oral use. It is a monosulfamyl diuretic that differs chemically from thiazide diuretics in that a double ring system is incorporated in its structure. It is a racemic mixture of 2-chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl) benzenesulfonamide, with the following structural formula: Chlorthalidone is practically insoluble in water, in ether and in chloroform; soluble in methanol; slightly soluble in alcohol. The inactive ingredients are colloidal silicon dioxide, lactose monohydrate, magnesium stearate, microcrystalline cellulose, povidone, sodium starch glycolate. chlorthalidone-struc-1.jpg
How to use
Initiate therapy with the lowest possible dose, then titrate according to individual patient response (2.1). • Hypertension: Recommended initial dose is 15 mg daily with food. If additional blood pressure reduction is needed, increase the dose to 25 mg (2.2). • Edema: Recommended initial dose is 50 mg to 100 mg daily or 100 mg on alternate days. Depending on response, dosage can be decreased or increased up to a maximum of 200 mg daily (2.3). 2.1 General Considerations THALITONE cannot be substituted with other formulations of chlorthalidone. Initiate therapy with the lowest possible dose, then titrate according to individual patient response. 2.2 Hypertension The initial recommended dose is 15 mg once daily with food. After 2 weeks, the dosage may be increased to a single daily dose of 25 mg if additional blood pressure reduction is needed. Doses above 25 mg are not expected to result in increased blood pressure reduction. 2.3 Edema The recommended initial dosage is 50 to 100 mg daily or 100 mg on alternate days. Depending on response, dosage can be decreased or increased up to a maximum of 200 mg daily.
Side effects
The following adverse reactions are described in more detail elsewhere in the label; • Hypotension [see Warnings and Precautions (5.1)] • Impaired Renal Function [see Warnings and Precautions (5.2)] • Electrolyte Abnormalities [see Warnings and Precautions (5.3)] • Metabolic Disturbances [see Warnings and Precautions (5.4)] The following adverse reactions have been observed, but there is not enough systematic collection of data to support an estimate of their frequency. Gastrointestinal System Reactions: anorexia, gastric irritation, nausea, vomiting, cramping, diarrhea, constipation, jaundice (intrahepatic cholestatic jaundice), pancreatitis. Central Nervous System Reactions : dizziness, paresthesias, headache. Hematologic Reactions: leukopenia, agranulocytosis, thrombocytopenia, aplastic anemia. Dermatologic-Hypersensitivity Reactions: purpura, photosensitivity, rash, urticaria, necrotizing angiitis (vasculitis) (cutaneous vasculitis), Lyell’s syndrome (toxic epidermal necrolysis). Cardiovascular Reaction: Orthostatic hypotension. Other Adverse Reactions: muscle spasm, weakness, restlessness, impotence, xanthopsia. The most frequently expected adverse drug reactions among patients receiving THALITONE are hypotension, dizziness, renal dysfunction, and electrolyte abnormalities (6). To report SUSPECTED ADVERSE REACTIONS, contact Casper Pharma LLC at 1-844-5-CASPER…
Warnings
Important safety information
Hypotension: Higher risk for patients with impaired sympathetic response, volume-depletion or salt restriction (5.1). • Renal Impairment: Patients with pre-existing kidney disease may be at higher risk. (5.2). • Monitor serum electrolytes periodically (5.3). 5.1 Hypotension THALITONE may cause symptomatic hypotension. Patients with impaired sympathetic response, volume-depletion or who are salt restricted may be at increased risk for developing hypotension. If hypotension occurs, place the patient in the supine position and, if necessary, give intravenous normal saline. A transient hypotensive response is not a contraindication to further treatment, which usually can be continued without difficulty once the blood pressure has stabilized. 5.2 Impaired Renal Function Changes in renal function including acute renal failure can be caused by diuretics. Patients with chronic kidney disease, heart failure, or volume depletion may be at particular risk of developing acute renal failure on THALITONE. Monitor renal function periodically. Consider withholding or discontinuing therapy in patients who develop a clinically significant decrease in renal function on THALITONE [see Drug Interactions (7)]. 5.3 Electrolyte Abnormalities THALITONE can cause hypokalemia, hyponatremia, hypochloremic alkalosis, and hypomagnesemia. Hypomagnesemia can result in hypokalemia which appears difficult to treat despite potassium repletion. Monitor serum electrolytes periodically. If hypokalemia is accompanied by clinical signs (e.g., muscular weakness, paresis, or ECG alterations), THALITONE should be discontinued. Correction of hypokalemia and any coexisting hypomagnesemia is recommended prior to the initiation of thiazides. 5.4 Metabolic Disturbances Chlorthalidone may alter glucose tolerance. Chlorthalidone may raise serum levels of cholesterol and triglycerides. Chlorthalidone may raise the serum uric acid level due to reduced clearance of uric acid and may cause or exacerbate hyperuricemia and precipitate gout in susceptible patients. Chlorthalidone decreases urinary calcium excretion and may cause elevations of serum calcium. Monitor calcium levels in patients with hypercalcemia receiving THALITONE.
Who should not take Thalitone
THALITONE is contraindicated in patients with anuria or hypersensitivity to chlorthalidone or other sulfonamide-derived drugs. • Anuria (4). • Hypersensitivity (4).
Overdose — what happens if you take too much
Symptoms of acute overdosage include nausea, weakness, dizziness and disturbances of electrolyte balance. The oral LD 50 of the drug in the mouse and the rat is more than 25,000 mg/kg body weight. The minimum lethal dose (MLD) in humans has not been established. There is no specific antidote but gastric lavage is recommended, followed by supportive treatment. Where necessary, this may include intravenous dextrose-saline with potassium, administered with caution.
U.S. Poison Control: call or text 1-800-222-1222 (free, 24/7). In an emergency call 911. From the FDA label; not medical advice.
Interactions
Effect of chlorthalidone on other drugs Chlorthalidone may add to or potentiate the action of other antihypertensive drugs. Chlorthalidone and related drugs may increase the responsiveness to tubocurarine. Lithium renal clearance is reduced by chlorthalidone, increasing the risk of lithium toxicity. Monitor serum lithium levels during concomitant use. • Antihypertensive drugs: Chlorthalidone may add to or potentiate the action of other antihypertensive drugs (7). • Lithium: Lithium renal clearance is reduced by chlorthalidone, increasing the risk of lithium toxicity (7).
How long does Chlorthalidone stay in your body?
The elimination half-life of chlorthalidone is about 40 hours on average (the label reports a mean half-life of 40 hours after a 50–200 mg dose, and an elimination half-life of 53 hours after 50 mg and 60 hours after 100 mg) — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. This is an older-format label (CLINICAL PHARMACOLOGY, not a PLR §12.3), and it gives its numbers in two ways: a mean half-life of 40 hours across the 50–200 mg dose range, and dose-specific elimination half-lives of 53 hours (50 mg) and 60 hours (100 mg). Only one phase is described, so the figures above are the elimination values the label states — it does not report a separate distribution phase. No active metabolite is described: the label says chlorthalidone is largely excreted unchanged by the kidneys and that data on metabolites and non-renal elimination routes "have yet to be clarified." It is not a prodrug. Do not confuse the half-life with the duration of diuretic effect — the label describes diuresis beginning in about 2.6 hours and continuing up to 72 hours, which is a different measure. The label does NOT quantify how the half-life changes with age, kidney impairment, or liver impairment; it gives no geriatric or renal/hepatic pharmacokinetic numbers. It does warn that cumulative effects of the drug may develop in patients with impaired renal function, and to use caution in severe renal disease and in impaired hepatic function — but it does not state a half-life for those groups, so no number should be inferred for them.
This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: DailyMed — CHLORTHALIDONE tablet (Clinical Pharmacology).
Drug class
May treat (source: NIH RxClass)
See how Thalitone ranks — best-rated thiazide-like diuretic for:
Dosage forms
Tablet
The forms currently marketed in the U.S., per the FDA National Drug Code Directory.
Ways to save
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Frequently asked questions
- What does Thalitone treat?
- Thalitone (Chlorthalidone) may be used to treat edema, glomerulonephritis, heart failure, hypertension, liver cirrhosis, nephrotic syndrome, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
- How much does Thalitone cost?
- Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $2.67 for 30, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.
- Is there a coupon or discount for Thalitone?
- pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Thalitone. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
- Who makes Thalitone?
- Thalitone is marketed by Casper Pharma LLC. You can see Casper Pharma LLC's full profile, rating, and other products on pharmaranks.
- Is Thalitone a brand-name or generic drug?
- Thalitone is a brand-name product with the active ingredient Chlorthalidone. Lower-cost generic equivalents containing Chlorthalidone are available — ask your pharmacist.
- Is Thalitone available over the counter?
- No. Thalitone is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
- What forms does Thalitone come in?
- Thalitone is currently marketed as tablet, per the FDA's National Drug Code Directory.
- What class of drug is Thalitone?
- Thalitone is classified as thiazide-like diuretic, per the FDA's Established Pharmacologic Class.
- Is Thalitone FDA-registered?
- Thalitone is on record with the U.S. FDA under application number NDA019574. You can verify this on its official FDA label.
- Is Thalitone safe?
- There's no single safe-or-not verdict, and we don't yet have a composite recall-safety score for Thalitone. Review its FDA-label side effects and warnings below, and always consult a licensed professional.
- What are the side effects of Thalitone?
- Thalitone's side effects are taken directly from its FDA label. From the label: The following adverse reactions are described in more detail elsewhere in the label; • Hypotension [see Warnings and Precautions (5.1)] • Impaired Renal Function [see Warnings and Precautions (5.2)] • Electrolyte Abnormalities [see Warnings and Precautions (5.3)] • Metabolic Disturbances [see Warnin… Both common and serious reactions are documented in full on this page. This is general reference from the FDA, not medical advice — always consult a professional.
Clinical content sourced from the FDA label via openFDA (U.S. FDA). View the FDA label on DailyMed → Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.
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