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Best beta-Adrenergic Blocker for heart failure

Top-rated pick: Inderal La — pharmaranks score 72/100, the highest of the 17 beta-Adrenergic Blocker drugs used for heart failure, ranked by our independent FDA recall-safety score. Compare them with all treatments for heart failure or the full beta-Adrenergic Blocker class. Not medical advice — always consult a professional.

Quick answer: Of the 17 beta-adrenergic blocker drugs we rate for heart failure, 14 are available as lower-cost generics, and most are solution. Our ranking reflects each drug’s FDA recall-safety record — not clinical effectiveness for heart failure; the right choice depends on your situation, so confirm it with your prescriber.

Rated against independent regulatory sources·Last updated October 10, 2026·How we rate

How beta-adrenergic blocker work

Beta-blockers block adrenaline (epinephrine) and noradrenaline from acting on beta-adrenergic receptors, mainly in the heart. This slows the heart rate, reduces how forcefully the heart contracts, and lowers blood pressure, easing the workload on the heart.

Source: Beta Blockers — StatPearls, NCBI Bookshelf (NIH)

Top beta-adrenergic blocker for heart failure: 1. Inderal La · 2. Innopran XL · 3. Betimol

Best-rated beta-Adrenergic Blocker for heart failure, ranked by pharmaranks score
#DrugRatingPharmacy pays
172/100$2View →
272/100$2View →
370/100$1View →
458/100$1View →
5Not yet rated—View →
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Full ranking · 17 drugs

#1 of 11 in beta-Adrenergic Blocker

inderal la

PrescriptionFDA-sourced

72/100

Inderal La (Propranolol Hydrochloride) is a beta-adrenergic blocker used to treat Angina Pectoris, Esophageal and Gastric Varices, Heart Failure, Hypertension.

(13 data points)
beta-adrenergic blockerangina pectorisesophageal and gastric varices

Pharmacy pays

From ~$1.51/30· 8 forms Save up to 76% in class
View details →
#1 of 11 in beta-Adrenergic Blocker

innopran xl

PrescriptionFDA-sourced

72/100

Innopran XL (Propranolol Hydrochloride) is a beta-adrenergic blocker used to treat Angina Pectoris, Esophageal and Gastric Varices, Heart Failure, Hypertension.

(13 data points)
beta-adrenergic blockerangina pectorisesophageal and gastric varices

Pharmacy pays

From ~$1.51/30· 8 forms Save up to 76% in class
View details →
THEA PHARMA logo

betimol

PrescriptionFDA-sourced

70/100

Betimol (Timolol) is a beta-adrenergic blocker used to treat Angina Pectoris, Open-Angle Glaucoma, Heart Failure, Hypertension.

(3 data points)
beta-adrenergic blockerangina pectorisglaucoma, open-angle

Pharmacy pays

From ~$0.63· 8 forms
View details →

atenolol

PrescriptionFDA-sourced

58/100

Atenolol is a beta-adrenergic blocker used to treat Angina Pectoris, Atrial Fibrillation, Atrial Flutter, Heart Failure.

(87 data points)
beta-adrenergic blockerangina pectorisatrial fibrillation

Pharmacy pays

From ~$0.66/30· 3 forms Save up to 23% in class
View details →

brevibloc

PrescriptionFDA-sourced

New

Brevibloc (Esmolol Hydrochloride) is a beta-adrenergic blocker used to treat Angina Pectoris, Heart Failure, Hypertension, Myocardial Infarction.

beta-adrenergic blockerangina pectorisheart failure

Price varies

View details →

brevibloc double strength in plastic container

PrescriptionFDA-sourced

New

Brevibloc Double Strength in Plastic Container (Esmolol Hydrochloride) is a beta-adrenergic blocker used to treat Angina Pectoris, Heart Failure, Hypertension, Myocardial Infarction.

beta-adrenergic blockerangina pectorisheart failure

Price varies

View details →

brevibloc in plastic container

PrescriptionFDA-sourced

New

Brevibloc in Plastic Container (Esmolol Hydrochloride) is a beta-adrenergic blocker used to treat Angina Pectoris, Heart Failure, Hypertension, Myocardial Infarction.

beta-adrenergic blockerangina pectorisheart failure

Price varies

View details →

hemangeol

PrescriptionFDA-sourced

New

Hemangeol (Propranolol Hydrochloride) is a beta-adrenergic blocker used to treat Angina Pectoris, Esophageal and Gastric Varices, Heart Failure, Hypertension.

beta-adrenergic blockerangina pectorisesophageal and gastric varices

Pharmacy pays

From ~$1.51/30· 8 forms Save up to 76% in class
View details →

istalol

PrescriptionFDA-sourced

New

Istalol (Timolol Maleate) is a beta-adrenergic blocker used to treat Angina Pectoris, Open-Angle Glaucoma, Heart Failure, Hypertension.

beta-adrenergic blockerangina pectorisglaucoma, open-angle

Pharmacy pays

From ~$0.63· 8 forms
View details →

kapspargo sprinkle

PrescriptionFDA-sourced

New

Kapspargo Sprinkle (Metoprolol Succinate) is a beta-adrenergic blocker used to treat Angina Pectoris, Atrial Fibrillation, Atrial Flutter, Heart Failure.

beta-adrenergic blockerangina pectorisatrial fibrillation

Pharmacy pays

From ~$0.51/30· 6 forms
View details →

lopressor

PrescriptionFDA-sourced

New

Lopressor (Metoprolol Tartrate) is a beta-adrenergic blocker used to treat Angina Pectoris, Atrial Fibrillation, Atrial Flutter, Heart Failure.

beta-adrenergic blockerangina pectorisatrial fibrillation

Pharmacy pays

From ~$0.51/30· 6 forms
View details →

metoprolol succinate

PrescriptionFDA-sourced

New

Metoprolol Succinate is a beta-adrenergic blocker used to treat Angina Pectoris, Atrial Fibrillation, Atrial Flutter, Heart Failure.

beta-adrenergic blockerangina pectorisatrial fibrillation

Pharmacy pays

From ~$0.51/30· 6 forms
View details →

tenormin

PrescriptionFDA-sourced

New

Tenormin (Atenolol) is a beta-adrenergic blocker used to treat Angina Pectoris, Atrial Fibrillation, Atrial Flutter, Heart Failure.

beta-adrenergic blockerangina pectorisatrial fibrillation

Pharmacy pays

From ~$0.66/30· 3 forms Save up to 23% in class
View details →

timoptic

PrescriptionFDA-sourced

New

Timoptic (Timolol Maleate) is a beta-adrenergic blocker used to treat Angina Pectoris, Open-Angle Glaucoma, Heart Failure, Hypertension.

beta-adrenergic blockerangina pectorisglaucoma, open-angle

Pharmacy pays

From ~$0.63· 8 forms
View details →

timoptic in ocudose

PrescriptionFDA-sourced

New

Timoptic in Ocudose (Timolol Maleate) is a beta-adrenergic blocker used to treat Angina Pectoris, Open-Angle Glaucoma, Heart Failure, Hypertension.

beta-adrenergic blockerangina pectorisglaucoma, open-angle

Pharmacy pays

From ~$0.63· 8 forms
View details →

timoptic-xe

PrescriptionFDA-sourced

New

Timoptic-Xe (Timolol Maleate) is a beta-adrenergic blocker used to treat Angina Pectoris, Open-Angle Glaucoma, Heart Failure, Hypertension.

beta-adrenergic blockerangina pectorisglaucoma, open-angle

Pharmacy pays

From ~$0.63· 8 forms
View details →

toprol-xl

PrescriptionFDA-sourced

New

Toprol-XL (Metoprolol Succinate) is a beta-adrenergic blocker used to treat Angina Pectoris, Atrial Fibrillation, Atrial Flutter, Heart Failure.

beta-adrenergic blockerangina pectorisatrial fibrillation

Pharmacy pays

From ~$0.51/30· 6 forms
View details →

Frequently asked

What is the best beta-adrenergic blocker for heart failure?
By our independent recall-safety rating — not an efficacy measure — inderal la ranks highest among beta-Adrenergic Blocker drugs used for heart failure. Always consult a professional.
Which beta-adrenergic blocker drugs treat heart failure?
pharmaranks lists 17 beta-Adrenergic Blocker products used for heart failure, per NIH RxClass drug-classification data — each independently rated and ranked above.
How are these ranked?
By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.

Where this ranking comes from

Our score is computed from public FDA data — not from opinion, sponsorship or user votes. How we rate.