Best Dipeptidyl Peptidase 4 Inhibitor for diabetes mellitus, type 2
Top-rated pick: Tradjenta — pharmaranks score 72/100, the highest of the 6 Dipeptidyl Peptidase 4 Inhibitor drugs used for diabetes mellitus, type 2, ranked by our independent FDA recall-safety score. Compare them with all treatments for diabetes mellitus, type 2 or the full Dipeptidyl Peptidase 4 Inhibitor class. Not medical advice — always consult a professional.
Quick answer: Of the 6 dipeptidyl peptidase 4 inhibitor drugs we rate for diabetes mellitus, type 2, 3 are available as lower-cost generics, and most are tablet. Our ranking reflects each drug’s FDA recall-safety record — not clinical effectiveness for diabetes mellitus, type 2; the right choice depends on your situation, so confirm it with your prescriber.
How dipeptidyl peptidase 4 inhibitor work
DPP-4 inhibitors block the enzyme that quickly destroys the body's own gut hormones (incretins like GLP-1). With these hormones lasting longer, the pancreas releases more insulin and less glucagon after meals, which lowers blood sugar.
Source: Dipeptidyl Peptidase IV (DPP IV) Inhibitors - StatPearls - NCBI Bookshelf
Other drug classes for diabetes mellitus, type 2
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Top dipeptidyl peptidase 4 inhibitor for diabetes mellitus, type 2: 1. Tradjenta · 2. Brynovin · 3. Januvia
| # | Drug | Rating | Type | Form | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|
| 1 | 72/100 | Prescription | Tablet | No data | — | View → | |
| 2 | 70/100 | Prescription | Solution | Generic | $111 | View → | |
| 3 | Not yet rated | Prescription | Tablet | Generic | $111 | View → | |
| 4 | Not yet rated | Prescription | Tablet | No data | — | View → | |
| 5 | Not yet rated | Prescription | Tablet | No data | — | View → | |
| 6 | Not yet rated | Prescription | Tablet | Generic | $111 | View → |
Full ranking · 6 drugs
tradjenta
PrescriptionFDA-sourced
Tradjenta (Linagliptin) is a dipeptidyl peptidase 4 inhibitor used to treat Type 2 Diabetes Mellitus.
brynovin
PrescriptionFDA-sourced
Brynovin (Sitagliptin Hydrochloride) is a dipeptidyl peptidase 4 inhibitor used to treat Type 2 Diabetes Mellitus.
Pharmacy pays
From ~$104.08/30· 3 formsjanuvia
PrescriptionFDA-sourced
Januvia (Sitagliptin Phosphate) is a dipeptidyl peptidase 4 inhibitor used to treat Type 2 Diabetes Mellitus.
Pharmacy pays
From ~$104.08/30· 3 forms
linagliptin
PrescriptionFDA-sourced
Linagliptin is a dipeptidyl peptidase 4 inhibitor used to treat Type 2 Diabetes Mellitus.
nesina
PrescriptionFDA-sourced
Nesina (Alogliptin Benzoate) is a dipeptidyl peptidase 4 inhibitor used to treat Type 2 Diabetes Mellitus.
zituvio
PrescriptionFDA-sourced
Zituvio (Sitagliptin) is a dipeptidyl peptidase 4 inhibitor used to treat Type 2 Diabetes Mellitus.
Pharmacy pays
From ~$104.08/30· 3 formsFrequently asked
- What is the best dipeptidyl peptidase 4 inhibitor for diabetes mellitus, type 2?
- By our independent recall-safety rating — not an efficacy measure — tradjenta ranks highest among Dipeptidyl Peptidase 4 Inhibitor drugs used for diabetes mellitus, type 2. Always consult a professional.
- Which dipeptidyl peptidase 4 inhibitor drugs treat diabetes mellitus, type 2?
- pharmaranks lists 6 Dipeptidyl Peptidase 4 Inhibitor products used for diabetes mellitus, type 2, per NIH RxClass drug-classification data — each independently rated and ranked above.
- How are these ranked?
- By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.