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DPP-4 inhibitors compared

Compare all 6 DPP-4 inhibitors side by side, used for conditions such as diabetes mellitus, type 2. DPP-4 inhibitors are the Dipeptidyl Peptidase 4 Inhibitor class. They share one FDA-defined mechanism but differ in approved uses, prescription status, brand-vs-generic options, price, and FDA recall-safety record — which our independent rating scores. The highest-rated is tradjenta.

Top-rated dipeptidyl peptidase 4 inhibitor: 1. Tradjenta · 2. Brynovin · 3. Januvia

Dipeptidyl Peptidase 4 Inhibitor drugs compared side by side, with pharmaranks' FDA recall-safety rating
DrugGenericSafety ratingFDA recall-based
TradjentaLinagliptin72/100
BrynovinSitagliptin Hydrochloride70/100
JanuviaSitagliptin PhosphateNot yet rated
Linagliptin—Not yet rated
NesinaAlogliptin BenzoateNot yet rated
ZituvioSitagliptinNot yet rated

The safety rating column is unique to pharmaranks — an independent 0–100 score from FDA regulatory recall data. Higher is safer. Not medical advice.

Best dipeptidyl peptidase 4 inhibitor by condition

for type 2 diabetes mellitus

Full ranking · 6 drugs

  1. 1

    tradjenta

    Linagliptin

    72/100
  2. 2

    brynovin

    Sitagliptin Hydrochloride

    70/100
  3. 3

    januvia

    Sitagliptin Phosphate

    New
  4. 4

    linagliptin

    Linagliptin

    New
  5. 5

    nesina

    Alogliptin Benzoate

    New
  6. 6

    zituvio

    Sitagliptin

    New

Frequently asked questions

What is the Dipeptidyl Peptidase 4 Inhibitor drug class?

Dipeptidyl Peptidase 4 Inhibitor is an FDA Established Pharmacologic Class (EPC) — a group of drugs that share a mechanism of action. pharmaranks lists 6 Dipeptidyl Peptidase 4 Inhibitor products, each independently rated.

Are all Dipeptidyl Peptidase 4 Inhibitor drugs the same?

No. Dipeptidyl Peptidase 4 Inhibitor drugs share the same core mechanism — that is why they sit in one FDA class — but they differ in their approved uses, available forms, whether they are prescription or over-the-counter, brand-vs-generic options and price, and their FDA recall-safety record.

Is "DPP-4 inhibitors" the same as the Dipeptidyl Peptidase 4 Inhibitor class?

Yes — "DPP-4 inhibitors" is the everyday name for the Dipeptidyl Peptidase 4 Inhibitor drug class. This page compares the 6 DPP-4 inhibitors pharmaranks rates, with our independent FDA recall-safety score for each.

What conditions do Dipeptidyl Peptidase 4 Inhibitor drugs treat?

Per NIH RxClass drug-classification data, Dipeptidyl Peptidase 4 Inhibitor drugs are used for conditions including diabetes mellitus, type 2.

Which Dipeptidyl Peptidase 4 Inhibitor drug is best-rated?

By our independent rating, tradjenta currently ranks highest among Dipeptidyl Peptidase 4 Inhibitor drugs. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.

Sources: the Dipeptidyl Peptidase 4 Inhibitor class definition and its member drugs come from the U.S. NLM RxClass (Established Pharmacologic Class); how the class works is summarized from Dipeptidyl Peptidase IV (DPP IV) Inhibitors - StatPearls - NCBI Bookshelf. Ratings are pharmaranks’ independent FDA recall-safety analysis.