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Can you drink alcohol with Cyclobenzaprine (Flexeril)?

Here is what the FDA-approved label for Cyclobenzaprine (Flexeril) actually says about alcohol — transcribed, not a secondhand guess.

By the pharmaranks editorial teamReviewed against the FDA drug label for Cyclobenzaprine sourcesUpdated Jul 21, 2026How we research

Cyclobenzaprine and alcohol, from the label

The label's WARNINGS section states that cyclobenzaprine may enhance the effects of alcohol, barbiturates, and other CNS depressants. Because cyclobenzaprine is closely related to the tricyclic antidepressants and is sedating, combining it with alcohol adds to central-nervous-system depression, so caution is advised with alcohol use during treatment.

Frequently asked questions

Can you drink alcohol while taking Cyclobenzaprine?

The label flags caution rather than an outright ban. Cyclobenzaprine and alcohol can add up (summarized above), so if you drink, do so carefully and know your own tolerance — and ask a pharmacist if you take other medicines.

How long after Cyclobenzaprine can you drink alcohol?

There is no single number that fits every drug, and the safe gap depends on why the two interact — a drug that adds to alcohol's sedation is a concern while it is still in your system, while a disulfiram-type reaction (like metronidazole's) is avoided during treatment and for a labeled period after the last dose. Follow the specific guidance above and ask the prescriber who wrote the prescription; do not guess a window.

What happens if you drink on Cyclobenzaprine?

The specific effect is described above, from the label. In most cases it means additive drowsiness and impaired coordination, or added strain on an organ the drug already affects — worse with more alcohol and in older adults. If you feel unwell after mixing the two, stop drinking and seek advice; call 911 for trouble breathing, fainting, or a rapid irregular heartbeat.

More guides for Cyclobenzaprine

Source

Cyclobenzaprine Hydrochloride Tablets — DailyMed label

Other drugs: Alprazolam · Baclofen · Bupropion · Buspirone · Clonazepam · Clonidine · Diazepam · Duloxetine · Fluoxetine · Hydrocodone · Hydroxyzine · Lorazepam · Methylphenidate · Mirtazapine · all drugs.

The alcohol interaction is transcribed from this drug’s FDA-approved label. This is general reference information, not medical advice. If you drink and take medication regularly, talk to your prescriber or pharmacist about your specific situation.