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flexeril

Flexeril (Cyclobenzaprine Hydrochloride) is a muscle relaxant used to treat Muscle Cramp, Muscle Rigidity, Muscle Spasticity, Myositis.

Cyclobenzaprine Hydrochloride · by Janssen Res and Dev

Not yet rated· sourced from the FDA label
Rated against independent regulatory sources·Last updated June 7, 2026·How we rate
Verified againstopenFDANIH DailyMedRxClass

Key facts

Drug class
Muscle Relaxant
Form
Tablet
Strength
Cyclobenzaprine Hydrochloride 10MG **Federal Register Determination That Product was not Discontinued or Withdrawn for Safety or Effectiveness reasons** · Cyclobenzaprine Hydrochloride 5MG **Federal Register Determination That Product was not Discontinued or Withdrawn for Safety or Effectiveness reasons**
Type
Prescription (Rx)
Brand or generic
Brand-name
Half-life
about 18 hours (range roughly 8 to 37 hours) for the standard immediate-release tablet in typical adults (how long it stays in your system)
What the pharmacy pays
~$0.63 for 30 — not your price
FDA application
NDA017821
Availability
Discontinued (per FDA)

How long does Cyclobenzaprine Hydrochloride stay in your body?

The elimination half-life of cyclobenzaprine hydrochloride is about 18 hours (range roughly 8 to 37 hours) for the standard immediate-release tablet in typical adults — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. Half-life varies by formulation and population: it is longer with the extended-release capsule (about 32 hours) and in adults over 65 (up to about 50 hours), and hepatic impairment roughly doubles drug exposure; no active metabolite with a materially longer half-life is described.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: CYCLOBENZAPRINE HYDROCHLORIDE tablet (DailyMed FDA label).

Drug class

How this class works, per Cyclobenzaprine - StatPearls - NCBI Bookshelf.

May treat (source: NIH RxClass)

See how Flexeril ranks — best-rated muscle relaxant for:

Dosage forms

Tablet

The forms currently marketed in the U.S., per the FDA National Drug Code Directory.

Ways to save

Ask for the generic

Same active ingredient, far cheaper. Is there a generic? →

Request a 90-day supply

Bulk fills usually lower the per-dose price vs monthly refills.

Use copay cards

Manufacturer copay cards & patient-assistance programs — especially for brand drugs.

Compare alternatives

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Frequently asked questions

What does Flexeril treat?
Flexeril (Cyclobenzaprine Hydrochloride) may be used to treat muscle cramp, muscle rigidity, muscle spasticity, myositis, pain, spasm, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
How does Flexeril work?
Flexeril is a muscle relaxant. Most muscle relaxants work in the brain and spinal cord rather than on the muscle itself: they damp down the overactive nerve signals and reflexes that keep muscles tense, easing spasms and tightness. Some specialized agents instead act directly on muscle calcium release.
How much does Flexeril cost?
Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $0.63 for 30, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.
Is there a coupon or discount for Flexeril?
pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Flexeril. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
Who makes Flexeril?
Flexeril is marketed by Janssen Res and Dev. You can see Janssen Res and Dev's full profile, rating, and other products on pharmaranks.
Is Flexeril a brand-name or generic drug?
Flexeril is a brand-name product with the active ingredient Cyclobenzaprine Hydrochloride.
Is Flexeril available over the counter?
No. Flexeril is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
What forms does Flexeril come in?
Flexeril is currently marketed as tablet, per the FDA's National Drug Code Directory.
What class of drug is Flexeril?
Flexeril is classified as muscle relaxant, per the FDA's Established Pharmacologic Class.
Is Flexeril FDA-registered?
Flexeril is on record with the U.S. FDA under application number NDA017821. You can verify this on its official FDA label.

Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.

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