FLEXERIL vs ROBAXIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. FLEXERIL and ROBAXIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	FLEXERIL	ROBAXIN
Rating	New	72/100
Pharmacy pays	~$0.63 /30	~$1.27 /30
Type	RX	RX
Active ingredient	CYCLOBENZAPRINE HYDROCHLORIDE	METHOCARBAMOL
Manufacturer	Janssen Res and Dev	Hikma
Dosage forms	Tablet	Injectable
Drug class	Muscle Relaxant	Muscle Relaxant
Boxed warning	None	None
Half-life	about 18 hours (range roughly 8 to 37 hours) for the standard immediate-release tablet in typical adults	about 1 to 2 hours
Treats	Muscle Cramp, Muscle Rigidity, Muscle Spasticity	Muscle Cramp, Muscle Rigidity, Myositis

flexeril robaxin

Rating

New

72/100

Pharmacy pays

~$0.63 /30

~$1.27 /30

Type

Active ingredient

CYCLOBENZAPRINE HYDROCHLORIDE

METHOCARBAMOL

Manufacturer

Janssen Res and Dev

Hikma

Dosage forms

Tablet

Injectable

Drug class

Muscle Relaxant

Boxed warning

None

Half-life

about 18 hours (range roughly 8 to 37 hours) for the standard immediate-release tablet in typical adults

about 1 to 2 hours

Treats

Muscle Cramp, Muscle Rigidity, Muscle Spasticity

Muscle Cramp, Muscle Rigidity, Myositis

Frequently asked questions

Which is cheaper, Flexeril or Robaxin?

Flexeril costs pharmacies less to acquire — about $0.63 vs $1.27 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Flexeril and Robaxin?

Flexeril contains Cyclobenzaprine Hydrochloride, while Robaxin contains Methocarbamol — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.