xipere
Xipere (Triamcinolone Acetonide) is a corticosteroid used to treat Adrenal Insufficiency, Hemolytic Anemia, Berylliosis, Bronchial Spasm.
Triamcinolone Acetonide · by Bausch and Lomb
Available as a generic: Triamcinolone Acetonide
Key facts
- Active ingredient
- Triamcinolone Acetonide
- Drug class
- Corticosteroid
- Form
- Injectable
- Strength
- Triamcinolone Acetonide 40MG/ML
- Type
- Prescription (Rx)
- Brand or generic
- Brand-name
- May treat
- adrenal insufficiency, hemolytic anemia, berylliosis
- Manufacturer
- Bausch and Lomb
- FDA application
- NDA211950
What is Xipere?
From the FDA label:XIPERE ® is a sterile, injectable suspension of triamcinolone acetonide, a synthetic corticosteroid for suprachoroidal use with the SCS Microinjector ® . Each mL of the aqueous suspension contains 40 mg of triamcinolone acetonide with 0.55% (weight/volume [w/v]) sodium chloride for tonicity, 0.5% (w/v) carboxymethylcellulose sodium, and 0.02% (w/v) polysorbate 80. It also contains potassium chloride, calcium chloride (dihydrate) and magnesium chloride (hexahydrate) as isotonicity agents, sodium acetate trihydrate(3.51 mg), sodium citrate dihydrate(1.53 mg), and water for injection. Hydrochloric acid may be used to adjust pH to a target value of 6.5. XIPERE ® does not contain an anti-microbial preservative. The chemical name for triamcinolone acetonide is 9-fluoro-11β,16ɑ,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone. Its chemical structure is: Molecular weight 434.50; molecular formula C 24 H 31 FO 6 Triamcinolone acetonide occurs as a white to cream-colored, crystalline powder having not more than a slight odor and is practically insoluble in water and very soluble in alcohol. XIPERE ® is provided as an injectable suspension in a single-dose glass vial with a rubber stopper and an aluminum seal. The SCS Microinjector ® is a piston syringe and a needle approximately 1 mm in length (900-µm and 1100-µm needles are included) for conducting the…
How to use
The recommended dosage is 4 mg (0.1 mL) administered as a suprachoroidal injection. ( 2.1 ) 2.1 Dosing Information For suprachoroidal injection using the SCS Microinjector ® . The recommended dose of XIPERE ® is 4 mg (0.1 mL of the 40 mg/mL injectable suspension). 2.2 Preparation for Administration Suprachoroidal injection is performed under aseptic conditions. The components for administration include: One single-dose glass vial of triamcinolone acetonide injectable suspension 40 mg/mL One SCS Microinjector ® syringe with vial adapter attached One 30-G x 900-µm needle One 30-G x 1100-µm needle Step 1 Figure A Remove the tray from the carton (see Figure A). The tray consists of two compartments: An open, non-sterile compartment that holds the vial A sealed compartment that contains a sterile tray Step 2 Figure B Examine the tray for damage (see Figure B). Ensure that the sealed compartment cover is intact and that there is no evidence of damage. If damage is present, do not use. Step 3 Figure C Remove the vial from the tray (see Figure C). Examine the vial and ensure there is no evidence of damage. Set aside for use in Step 6. Step 4 Figure D Peel off the compartment cover, exposing the sterile tray (see Figure D). Step 5 Figure E Grasp and hold the long sides of the tray and invert the tray. Squeeze gently to release the sterile tray onto the appropriate sterile preparation…
Side effects
In controlled studies, the most common adverse reactions reported by ≥ 10% of patients and at a rate greater than control included elevated intraocular pressure and eye pain. ( 6.1 ) To report SUSPECTED ADVERSE REACTIONS, contact Bausch & Lomb Incorporated at 1-800-553-5340 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. XIPERE ® was studied in a multicenter, randomized, sham-controlled, double-masked study in patients with macular edema associated with uveitis. Table 1 summarizes data available from the clinical trial for XIPERE ® treated patients and control patients. The most common ocular (study eye) adverse reactions occurring in ≥ 2% of patients and non-ocular adverse reactions occurring in ≥ 5% of patients are shown in Table 1. Table 1: Ocular Adverse Reactions Reported in ≥ 2% of Patients and Non-ocular Adverse Reactions Reported in ≥ 5% of Patients a Includes intraocular pressure increased and ocular hypertension b Defined as not occurring on the day of the injection procedure, or occurring on the day of the injection procedure and not resolving the same day c Includes…
Warnings
Important safety information
Potential Corticosteroid-Related Effects : Use of corticosteroids may produce cataracts, increased intraocular pressure, and glaucoma. ( 5.1 ) 5.1 Potential Corticosteroid-Related Effects Use of corticosteroids may produce cataracts, increased intraocular pressure, and glaucoma. Use of corticosteroids may enhance the establishment of secondary ocular infections due to bacteria, fungi, or viruses. Corticosteroids should be used cautiously in patients with a history of ocular herpes simplex. Corticosteroids should not be used in patients with active ocular herpes simplex. 5.2 Alterations in Endocrine Function Hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing’s syndrome, and hyperglycemia can occur following administration of a corticosteroid. Monitor patients for these conditions with chronic use. Corticosteroids can produce reversible HPA axis suppression with the potential for glucocorticosteroid insufficiency after withdrawal of treatment. Drug induced secondary adrenocortical insufficiency may be minimized by gradual reduction of dosage. This type of relative insufficiency may persist for months after discontinuation of therapy; therefore, in any situation of stress occurring during that period, hormone therapy should be reinstituted. Metabolic clearance of corticosteroids is decreased in hypothyroid patients and increased in hyperthyroid patients. Changes in thyroid status of the patient may necessitate adjustment in dosage.
Who should not take Xipere
Ocular or periocular infections ( 4.1 ) Hypersensitivity to triamcinolone or any component of this product ( 4.2 ) 4.1 Ocular or Periocular Infections XIPERE ® is contraindicated in patients with active or suspected ocular or periocular infections including most viral diseases of the cornea and conjunctiva, including active epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, varicella, mycobacterial infections, and fungal diseases. 4.2 Hypersensitivity XIPERE ® is contraindicated in patients with known hypersensitivity to triamcinolone acetonide or any other components of this product.
Drug class
How this class works, per Corticosteroids - StatPearls - NCBI Bookshelf.
May treat (source: NIH RxClass)
- adrenal insufficiency
- hemolytic anemia
- berylliosis
- bronchial spasm
- ulcerative colitis
- dermatitis herpetiformis
See how Xipere ranks — best-rated corticosteroid for:
Dosage forms
Injectable
The forms currently marketed in the U.S., per the FDA National Drug Code Directory.
Ways to save
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Request a 90-day supply
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Use copay cards
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Frequently asked questions
- What does Xipere treat?
- Xipere (Triamcinolone Acetonide) may be used to treat adrenal insufficiency, hemolytic anemia, berylliosis, bronchial spasm, ulcerative colitis, dermatitis herpetiformis, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
- How does Xipere work?
- Xipere is a corticosteroid. Corticosteroids mimic the body's natural stress hormone cortisol: they enter cells and bind a glucocorticoid receptor that switches off genes for inflammatory chemicals, calming swelling, redness, and an overactive immune response.
- Is there a coupon or discount for Xipere?
- pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Xipere. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
- Who makes Xipere?
- Xipere is marketed by Bausch and Lomb. You can see Bausch and Lomb's full profile, rating, and other products on pharmaranks.
- Is Xipere a brand-name or generic drug?
- Xipere is a brand-name product with the active ingredient Triamcinolone Acetonide. Lower-cost generic equivalents containing Triamcinolone Acetonide are available — ask your pharmacist.
- Is Xipere available over the counter?
- No. Xipere is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
- What forms does Xipere come in?
- Xipere is currently marketed as injectable, per the FDA's National Drug Code Directory.
- What class of drug is Xipere?
- Xipere is classified as corticosteroid, per the FDA's Established Pharmacologic Class.
- Is Xipere FDA-registered?
- Xipere is on record with the U.S. FDA under application number NDA211950. You can verify this on its official FDA label.
- Is Xipere safe?
- There's no single safe-or-not verdict, and we don't yet have a composite recall-safety score for Xipere. Review its FDA-label side effects and warnings below, and always consult a licensed professional.
- What are the side effects of Xipere?
- Xipere's side effects are taken directly from its FDA label. From the label: In controlled studies, the most common adverse reactions reported by ≥ 10% of patients and at a rate greater than control included elevated intraocular pressure and eye pain. ( 6.1 ) To report SUSPECTED ADVERSE REACTIONS,… Both common and serious reactions are documented in full on this page. This is general reference from the FDA, not medical advice — always consult a professional.
Clinical content sourced from the FDA label via openFDA (U.S. FDA). View the FDA label on DailyMed → Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.
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