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desowen

Desowen (Desonide) is a corticosteroid used to treat Facial Dermatoses, Foot Dermatoses, Hand Dermatoses, Inflammation.

Desonide · by Galderma Labs LP

Available as a generic: Desonide

Not yet rated· sourced from the FDA label
Rated against independent regulatory sources·Last updated June 7, 2026·How we rate
Verified againstopenFDANIH DailyMedRxClass
$0.28 /g
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Key facts

Active ingredient
Desonide
Drug class
Corticosteroid
Form
Topical
Strength
Desonide 0.05%
Type
Prescription (Rx)
Brand or generic
Brand-name
Manufacturer
Galderma Labs LP
What the pharmacy pays
~$0.28 per gm — not your price
FDA application
NDA019048

What is Desowen?

From the FDA label:Desonide Cream 0.05% and Lotion 0.05% contain desonide (Pregna-1,4-diene-3,20-dione,11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-,(11β,16α)- a synthetic nonfluorinated corticosteroid for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and anti-pruritic agents. Chemically, desonide is C 24 H 32 O 6 . It has the following structural formula: Desonide has the molecular weight of 416.51. It is a white to off white odorless powder which is soluble in methanol and practically insoluble in water. Each gram of Desonide Cream contains 0.5 mg of desonide in a base of citric acid, emulsifying wax, isopropyl palmitate, polysorbate 60, potassium sorbate, propyl gallate, propylene glycol, purified water, sodium hydroxide, sorbic acid, stearic acid, and synthetic beeswax. Each gram of Desonide Lotion contains 0.5 mg of desonide in a base of cetyl alcohol, edetate sodium, glyceryl stearate SE, light mineral oil, methylparaben, propylene glycol, propylparaben, purified water, sodium lauryl sulfate, sorbitan monostearate, and stearyl alcohol. May contain citric acid and/or sodium hydroxide for pH adjustment. deso-structure

How to use

Desonide Cream or Lotion should be applied to the affected areas as a thin film two or three times daily depending on the severity of the condition. SHAKE LOTION WELL BEFORE USING. As with other corticosteroids, therapy should be discontinued when control is achieved. If no improvement is seen within 2 weeks, reassessment of diagnosis may be necessary. Desonide Cream and Lotion should not be used with occlusive dressings.

Side effects

In controlled clinical trials, the total incidence of adverse reactions associated with the use of desonide was approximately 8%. These were: stinging and burning approximately 3%, irritation, contact dermatitis, condition worsened, peeling of skin, itching, intense transient erythema, and dryness/scaliness, each less than 2%. The following additional local adverse reactions have been reported infrequently with other topical corticosteroids, and they may occur more frequently with the use of occlusive dressings, especially with higher potency corticosteroids. These reactions are listed in an approximate decreasing order of occurrence: folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, secondary infection, skin atrophy, striae, and miliaria.

Who should not take Desowen

Desonide Cream and Lotion are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparations.

Overdose — what happens if you take too much

Topically applied Desonide Cream and Lotion can be absorbed in sufficient amounts to produce systemic effects (See PRECAUTIONS).

U.S. Poison Control: call or text 1-800-222-1222 (free, 24/7). In an emergency call 911. From the FDA label; not medical advice.

Drug class

How this class works, per Corticosteroids - StatPearls - NCBI Bookshelf.

May treat (source: NIH RxClass)

Dosage forms

Topical

The forms currently marketed in the U.S., per the FDA National Drug Code Directory.

Ways to save

Ask for the generic

Same active ingredient, far cheaper. Is there a generic? →

Request a 90-day supply

Bulk fills usually lower the per-dose price vs monthly refills.

Use copay cards

Manufacturer copay cards & patient-assistance programs — especially for brand drugs.

Compare alternatives

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Frequently asked questions

What does Desowen treat?
Desowen (Desonide) may be used to treat facial dermatoses, foot dermatoses, hand dermatoses, inflammation, leg dermatoses, scalp dermatoses, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
How does Desowen work?
Desowen is a corticosteroid. Corticosteroids mimic the body's natural stress hormone cortisol: they enter cells and bind a glucocorticoid receptor that switches off genes for inflammatory chemicals, calming swelling, redness, and an overactive immune response.
How much does Desowen cost?
Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $0.28 per gm, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.
Is there a coupon or discount for Desowen?
pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Desowen. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
Who makes Desowen?
Desowen is marketed by Galderma Labs LP. You can see Galderma Labs LP's full profile, rating, and other products on pharmaranks.
Is Desowen a brand-name or generic drug?
Desowen is a brand-name product with the active ingredient Desonide. Lower-cost generic equivalents containing Desonide are available — ask your pharmacist.
Is Desowen available over the counter?
No. Desowen is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
What forms does Desowen come in?
Desowen is currently marketed as topical, per the FDA's National Drug Code Directory.
What class of drug is Desowen?
Desowen is classified as corticosteroid, per the FDA's Established Pharmacologic Class.
Is Desowen FDA-registered?
Desowen is on record with the U.S. FDA under application number NDA019048. You can verify this on its official FDA label.
Is Desowen safe?
There's no single safe-or-not verdict, and we don't yet have a composite recall-safety score for Desowen. Review its FDA-label side effects and warnings below, and always consult a licensed professional.
What are the side effects of Desowen?
Desowen's side effects are taken directly from its FDA label. From the label: In controlled clinical trials, the total incidence of adverse reactions associated with the use of desonide was approximately 8%. These were: stinging and burning approximately 3%, irritation, contact dermatitis, condition worsened, peeling of skin, itching, intense transient erythema,… Both common and serious reactions are documented in full on this page. This is general reference from the FDA, not medical advice — always consult a professional.

Clinical content sourced from the FDA label via openFDA (U.S. FDA). View the FDA label on DailyMed → Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.

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