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tofranil

Pharmaranks rates Tofranil 3.5/5 for recall safety — an independent score from its FDA recall history and its manufacturer's record. Tofranil (Imipramine Hydrochloride) is a tricyclic antidepressant used to treat Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Enuresis, Pain.

Imipramine Hydrochloride · by Novartis

Available as a generic: Imipramine Hydrochloride

70/100Limited · 1 source

Based on 1 source · Recall-safety score from FDA recall history — this product's own recalls and its manufacturer's record. Not an efficacy or quality rating. methodology →

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate
Verified againstopenFDANIH DailyMedRxClass

Key facts

Active ingredient
Imipramine Hydrochloride
Form
Tablet, Injectable
Strength
Imipramine Hydrochloride 12.5MG/ML
Type
Prescription (Rx)
Brand or generic
Brand-name
Manufacturer
Novartis
What the pharmacy pays
~$2.54 for 30 — not your price
FDA application
NDA011838
Availability
Discontinued (per FDA)

Drug class

May treat (source: NIH RxClass)

See how Tofranil ranks — best-rated tricyclic antidepressant for:

Dosage forms

Tablet and Injectable

The forms currently marketed in the U.S., per the FDA National Drug Code Directory.

Ways to save

Ask for the generic

Same active ingredient, far cheaper. Is there a generic? →

Request a 90-day supply

Bulk fills usually lower the per-dose price vs monthly refills.

Use copay cards

Manufacturer copay cards & patient-assistance programs — especially for brand drugs.

Compare alternatives

A same-class option may cost less. See alternatives →

Frequently asked questions

What does Tofranil treat?
Tofranil (Imipramine Hydrochloride) may be used to treat attention deficit disorder with hyperactivity, depressive disorder, enuresis, pain, panic disorder, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
How is Tofranil rated?
pharmaranks gives Tofranil a composite score of 3.5 out of 5, currently based on 1 weighted source (FDA regulatory recall-safety data weighted highest). See our methodology at /how-we-rate.
How much does Tofranil cost?
Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $2.54 for 30, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.
Is there a coupon or discount for Tofranil?
pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Tofranil. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
Who makes Tofranil?
Tofranil is marketed by Novartis. You can see Novartis's full profile, rating, and other products on pharmaranks.
Is Tofranil a brand-name or generic drug?
Tofranil is a brand-name product with the active ingredient Imipramine Hydrochloride. Lower-cost generic equivalents containing Imipramine Hydrochloride are available — ask your pharmacist.
Is Tofranil available over the counter?
No. Tofranil is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
What forms does Tofranil come in?
Tofranil is currently marketed as tablet and injectable, per the FDA's National Drug Code Directory.
What class of drug is Tofranil?
Tofranil is classified as tricyclic antidepressant, per the FDA's Established Pharmacologic Class.
Is Tofranil FDA-registered?
Tofranil is on record with the U.S. FDA under application number NDA011838. You can verify this on its official FDA label.
Has Tofranil been recalled by the FDA?
Tofranil has no FDA recalls recorded under its own application in the openFDA enforcement database. Its recall-safety score reflects its manufacturer's overall recall record. This is general reference, not medical advice — check the FDA recall database for the latest alerts.
Is Tofranil safe?
There's no single safe-or-not verdict. pharmaranks gives Tofranil a recall-safety score of 70/100, based on its FDA recall history (no recalls under its own FDA application) — not an efficacy or side-effect rating. Review its FDA-label side effects and warnings before use, and always consult a licensed professional.

Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.

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tofranil

70/100