Best Tricyclic Antidepressant for panic disorder
Top-rated pick: Imipramine Hydrochloride — pharmaranks score 72/100, the highest of the 2 Tricyclic Antidepressant drugs used for panic disorder, ranked by our independent FDA recall-safety score. Compare them with all treatments for panic disorder or the full Tricyclic Antidepressant class. Not medical advice — always consult a professional.
Quick answer: Of the 2 tricyclic antidepressant drugs we rate for panic disorder, all are available as lower-cost generics, and most are tablet. Our ranking reflects each drug’s FDA recall-safety record — not clinical effectiveness for panic disorder; the right choice depends on your situation, so confirm it with your prescriber.
Other drug classes for panic disorder
Top tricyclic antidepressant for panic disorder: 1. Imipramine Hydrochloride · 2. Anafranil
| # | Drug | Rating | Type | Form | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|
| 1 | 72/100 | Prescription | Tablet | Generic | $3 | View → | |
| 2 | 70/100 | Prescription | Capsule | Generic | $7 | View → |
Full ranking · 2 drugs
imipramine hydrochloride
Boxed warningPrescriptionFDA-sourced
Imipramine Hydrochloride is a tricyclic antidepressant used to treat Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Enuresis, Pain.
Pharmacy pays
From ~$2.26/30· 3 formsanafranil
Boxed warningPrescriptionFDA-sourced
Anafranil (Clomipramine Hydrochloride) is a tricyclic antidepressant used to treat Depressive Disorder, Obsessive-Compulsive Disorder, Pain, Panic Disorder.
Pharmacy pays
From ~$5.85/30· 3 forms Save up to 64% in classFrequently asked
- What is the best tricyclic antidepressant for panic disorder?
- By our independent recall-safety rating — not an efficacy measure — imipramine hydrochloride ranks highest among Tricyclic Antidepressant drugs used for panic disorder. Always consult a professional.
- Which tricyclic antidepressant drugs treat panic disorder?
- pharmaranks lists 2 Tricyclic Antidepressant products used for panic disorder, per NIH RxClass drug-classification data — each independently rated and ranked above.
- How are these ranked?
- By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.
Where this ranking comes from
Our score is computed from public FDA data — not from opinion, sponsorship or user votes. How we rate.
- FDA Drug Enforcement (recall) database — the recall history behind the safety score
- DailyMed (NIH National Library of Medicine) — the FDA labels we quote for uses, dosing and warnings
- Drugs@FDA — approvals, strengths and marketing status