AMITRIPTYLINE HYDROCHLORIDE vs TOFRANIL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. AMITRIPTYLINE HYDROCHLORIDE and TOFRANIL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AMITRIPTYLINE HYDROCHLORIDE	TOFRANIL
Rating	68/100	70/100
Pharmacy pays	~$2.72 /30	~$2.54 /30
Type	RX	RX
Active ingredient	AMITRIPTYLINE HYDROCHLORIDE	IMIPRAMINE HYDROCHLORIDE
Manufacturer	Sandoz	Novartis
Dosage forms	Tablet	Tablet, Injectable
Drug class	Tricyclic Antidepressant	Tricyclic Antidepressant
Boxed warning	Boxed warning	None
Treats	Depressive Disorder, Pain	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Enuresis

amitriptyline hydrochloride tofranil

Rating

68/100

70/100

Pharmacy pays

~$2.72 /30

~$2.54 /30

Type

Active ingredient

AMITRIPTYLINE HYDROCHLORIDE

IMIPRAMINE HYDROCHLORIDE

Manufacturer

Sandoz

Novartis

Dosage forms

Tablet

Tablet, Injectable

Drug class

Tricyclic Antidepressant

Boxed warning

None

Treats

Depressive Disorder, Pain

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Enuresis

Get amitriptyline hydrochloride

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Frequently asked questions

Which is better-rated, Amitriptyline Hydrochloride or Tofranil?

By our independent rating, Tofranil scores higher — 3.5 vs 3.4 out of 5 for Amitriptyline Hydrochloride. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Amitriptyline Hydrochloride or Tofranil?

Tofranil costs pharmacies less to acquire — about $2.54 vs $2.72 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Amitriptyline Hydrochloride and Tofranil?

Amitriptyline Hydrochloride contains Amitriptyline Hydrochloride, while Tofranil contains Imipramine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.