tenex
Tenex (Guanfacine Hydrochloride) is a central alpha-2 adrenergic agonist used to treat Attention Deficit Disorder with Hyperactivity, Hypertension.
Guanfacine Hydrochloride · by Promius Pharma
Available as a generic: Guanfacine Hydrochloride
Key facts
- Active ingredient
- Guanfacine Hydrochloride
- Drug class
- Central Alpha-2 Adrenergic Agonist
- Form
- Tablet
- Strength
- Guanfacine Hydrochloride EQ 1MG Base **Federal Register Determination That Product was not Discontinued or Withdrawn for Safety or Effectiveness reasons** · Guanfacine Hydrochloride EQ 2MG Base **Federal Register Determination That Product was not Discontinued or Withdrawn for Safety or Effectiveness reasons** · Guanfacine Hydrochloride EQ 3MG Base **Federal Register Determination That Product was not Discontinued or Withdrawn for Safety or Effectiveness reasons**
- Type
- Prescription (Rx)
- Brand or generic
- Brand-name
- Manufacturer
- Promius Pharma
- What the pharmacy pays
- ~$5.20 for 30 — not your price
- FDA application
- NDA019032
- Availability
- Discontinued (per FDA)
Drug class
How this class works, per Clonidine - StatPearls - NCBI Bookshelf.
May treat (source: NIH RxClass)
See how Tenex ranks — best-rated central alpha-2 adrenergic agonist for:
Dosage forms
Tablet
The forms currently marketed in the U.S., per the FDA National Drug Code Directory.
Ways to save
Ask for the generic
Same active ingredient, far cheaper. Is there a generic? →
Request a 90-day supply
Bulk fills usually lower the per-dose price vs monthly refills.
Use copay cards
Manufacturer copay cards & patient-assistance programs — especially for brand drugs.
Compare alternatives
A same-class option may cost less. See alternatives →
Frequently asked questions
- What does Tenex treat?
- Tenex (Guanfacine Hydrochloride) may be used to treat attention deficit disorder with hyperactivity, hypertension, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
- How does Tenex work?
- Tenex is a central alpha-2 adrenergic agonist. These drugs activate alpha-2 receptors in the brainstem, which tells the nervous system to send out less norepinephrine and reduce sympathetic (fight-or-flight) signaling to the body. With less of this stimulation, blood vessels relax and heart rate slows, lowering blood pressure.
- How much does Tenex cost?
- Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $5.20 for 30, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins. Pharmacies pay less for a same-class option, Clonidine Hydrochloride — about $1.05 on the same basis.
- Is there a coupon or discount for Tenex?
- pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Tenex. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
- Who makes Tenex?
- Tenex is marketed by Promius Pharma. You can see Promius Pharma's full profile, rating, and other products on pharmaranks.
- Is Tenex a brand-name or generic drug?
- Tenex is a brand-name product with the active ingredient Guanfacine Hydrochloride. Lower-cost generic equivalents containing Guanfacine Hydrochloride are available — ask your pharmacist.
- Is Tenex available over the counter?
- No. Tenex is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
- What forms does Tenex come in?
- Tenex is currently marketed as tablet, per the FDA's National Drug Code Directory.
- What class of drug is Tenex?
- Tenex is classified as central alpha-2 adrenergic agonist, per the FDA's Established Pharmacologic Class.
- Is Tenex FDA-registered?
- Tenex is on record with the U.S. FDA under application number NDA019032. You can verify this on its official FDA label.
Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.
What people report to the FDA about GUANFACINE HYDROCHLORIDE
The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 1,046 reports naming GUANFACINE HYDROCHLORIDE — the active ingredient in Tenex, and the FDA flagged 61% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:
- fatigue60 reports
- somnolence57 reports
- aggression46 reports
- insomnia46 reports
- agitation42 reports
- headache42 reports
- dizziness39 reports
- vomiting37 reports
Read these as a signal, not a rate. A report does not mean GUANFACINE HYDROCHLORIDE caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label.
Source: openFDA drug/event (FAERS), retrieved September 25, 2026.
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