Best Central alpha-2 Adrenergic Agonist for attention deficit disorder with hyperactivity
Top-rated pick: Clonidine Hydrochloride — pharmaranks score 72/100, the highest of the 9 Central alpha-2 Adrenergic Agonist drugs used for attention deficit disorder with hyperactivity, ranked by our independent FDA recall-safety score. Compare them with all treatments for attention deficit disorder with hyperactivity or the full Central alpha-2 Adrenergic Agonist class. Not medical advice — always consult a professional.
Quick answer: Of the 9 central alpha-2 adrenergic agonist drugs we rate for attention deficit disorder with hyperactivity, all are available as lower-cost generics, and most are patch. Our ranking reflects each drug’s FDA recall-safety record — not clinical effectiveness for attention deficit disorder with hyperactivity; the right choice depends on your situation, so confirm it with your prescriber.
How central alpha-2 adrenergic agonist work
These drugs activate alpha-2 receptors in the brainstem, which tells the nervous system to send out less norepinephrine and reduce sympathetic (fight-or-flight) signaling to the body. With less of this stimulation, blood vessels relax and heart rate slows, lowering blood pressure.
Other drug classes for attention deficit disorder with hyperactivity
Top central alpha-2 adrenergic agonist for attention deficit disorder with hyperactivity: 1. Clonidine Hydrochloride · 2. Guanfacine Hydrochloride · 3. Onyda XR
| # | Drug | Rating | Type | Form | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|
| 1 | 72/100 | Prescription | Injectable | Generic | $1 | View → | |
| 2 | 72/100 | Prescription | Tablet | Generic | $5 | View → | |
| 3 | 72/100 | Prescription | Suspension | Generic | $1 | View → | |
| 4 | 70/100 | Prescription | Solution | Generic | $1 | View → | |
| 5 | 68/100 | Prescription | Injectable | Generic | $1 | View → | |
| 6 | Not yet rated | Prescription | Patch | Generic | $1 | View → | |
| 7 | Not yet rated | Prescription | Patch | Generic | $1 | View → | |
| 8 | Not yet rated | Prescription | Patch | Generic | $1 | View → | |
| 9 | Not yet rated | Prescription | Tablet | Generic | $1 | View → |
Full ranking · 9 drugs
clonidine hydrochloride
PrescriptionFDA-sourced
Clonidine Hydrochloride is a central alpha-2 adrenergic agonist used to treat Attention Deficit Disorder with Hyperactivity, Diarrhea, Dysmenorrhea, Tourette Syndrome.
Pharmacy pays
From ~$0.75/30· 8 forms Save up to 5% in classguanfacine hydrochloride
PrescriptionFDA-sourced
Guanfacine Hydrochloride is a central alpha-2 adrenergic agonist used to treat Attention Deficit Disorder with Hyperactivity, Hypertension.
Pharmacy pays
From ~$4.36/30· 6 forms Save up to 81% in classonyda xr
PrescriptionFDA-sourced
Onyda XR (Clonidine Hydrochloride) is a central alpha-2 adrenergic agonist used to treat Attention Deficit Disorder with Hyperactivity, Diarrhea, Dysmenorrhea, Tourette Syndrome.
Pharmacy pays
From ~$0.75/30· 8 forms Save up to 5% in classjavadin
PrescriptionFDA-sourced
Javadin (Clonidine Hydrochloride) is a central alpha-2 adrenergic agonist used to treat Attention Deficit Disorder with Hyperactivity, Diarrhea, Dysmenorrhea, Tourette Syndrome.
Pharmacy pays
From ~$0.75/30· 8 forms Save up to 5% in classduraclon
Boxed warningPrescriptionFDA-sourced
Duraclon (Clonidine Hydrochloride) is a central alpha-2 adrenergic agonist used to treat Attention Deficit Disorder with Hyperactivity, Diarrhea, Dysmenorrhea, Tourette Syndrome.
Pharmacy pays
From ~$0.75/30· 8 forms Save up to 5% in class
catapres-tts-1
PrescriptionFDA-sourced
Catapres-Tts-1 (Clonidine) is a central alpha-2 adrenergic agonist used to treat Attention Deficit Disorder with Hyperactivity, Diarrhea, Dysmenorrhea, Tourette Syndrome.
Pharmacy pays
From ~$0.75/30· 8 forms Save up to 5% in classcatapres-tts-2
PrescriptionFDA-sourced
Catapres-Tts-2 (Clonidine) is a central alpha-2 adrenergic agonist used to treat Attention Deficit Disorder with Hyperactivity, Diarrhea, Dysmenorrhea, Tourette Syndrome.
Pharmacy pays
From ~$0.75/30· 8 forms Save up to 5% in classcatapres-tts-3
PrescriptionFDA-sourced
Catapres-Tts-3 (Clonidine) is a central alpha-2 adrenergic agonist used to treat Attention Deficit Disorder with Hyperactivity, Diarrhea, Dysmenorrhea, Tourette Syndrome.
Pharmacy pays
From ~$0.75/30· 8 forms Save up to 5% in classnexiclon xr
PrescriptionFDA-sourced
Nexiclon XR (Clonidine) is a central alpha-2 adrenergic agonist used to treat Attention Deficit Disorder with Hyperactivity, Diarrhea, Dysmenorrhea, Tourette Syndrome.
Pharmacy pays
From ~$0.75/30· 8 forms Save up to 5% in classFrequently asked
- What is the best central alpha-2 adrenergic agonist for attention deficit disorder with hyperactivity?
- By our independent recall-safety rating — not an efficacy measure — clonidine hydrochloride ranks highest among Central alpha-2 Adrenergic Agonist drugs used for attention deficit disorder with hyperactivity. Always consult a professional.
- Which central alpha-2 adrenergic agonist drugs treat attention deficit disorder with hyperactivity?
- pharmaranks lists 9 Central alpha-2 Adrenergic Agonist products used for attention deficit disorder with hyperactivity, per NIH RxClass drug-classification data — each independently rated and ranked above.
- How are these ranked?
- By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.