periostat

Foods & drinks to be careful with

Well-established interactions for this medicine’s drug class, summarized from public health authorities. General information, not medical advice — always confirm with your pharmacist or the label.

• Dairy, calcium, iron & antacids

  Watch out for: milk and other dairy, calcium- or iron-fortified foods and supplements, and antacids.

  Calcium, magnesium, and iron bind to these antibiotics in the gut and can stop them from being absorbed, making the medicine work less well.

  What to do: Separate the antibiotic from dairy, supplements, and antacids by a couple of hours — take it at the interval the label or your pharmacist specifies.

  Source: Tetracycline — MedlinePlus (U.S. National Library of Medicine) · Ciprofloxacin (a fluoroquinolone) — MedlinePlus (U.S. National Library of Medicine)

How long does Doxycycline Hyclate stay in your body?

The elimination half-life of doxycycline hyclate is about 16 to 22 hours in healthy adults — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. This is the elimination half-life of doxycycline itself; it has no active metabolite with a longer half-life, and the half-life stays about the same (18 to 22 hours) even with severe kidney impairment and is not shortened by hemodialysis.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: DOXYCYCLINE MONOHYDRATE capsule — DailyMed (Clinical Pharmacology / Pharmacokinetics).

Frequently asked questions

What does Periostat treat?

Periostat (Doxycycline Hyclate) may be used to treat anthrax, campylobacter infections, cholera, granuloma inguinale, mycoplasma infections, psittacosis, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.

How does Periostat work?

Periostat is a tetracycline-class drug. Tetracyclines slip inside bacteria and bind to the 30S part of their ribosome, the cell's protein-building machine. This blocks the bacteria from adding new amino acids, so they can't make the proteins they need to grow or multiply, letting the immune system clear the infection.

How much does Periostat cost?

Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $0.12 per ml, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.

Is there a coupon or discount for Periostat?

pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Periostat. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.

Who makes Periostat?

Periostat is marketed by Collagenex. You can see Collagenex's full profile, rating, and other products on pharmaranks.

Is Periostat a brand-name or generic drug?

Periostat is a brand-name product with the active ingredient Doxycycline Hyclate. Lower-cost generic equivalents containing Doxycycline Hyclate are available — ask your pharmacist.

Is Periostat available over the counter?

No. Periostat is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.

What forms does Periostat come in?

Periostat is currently marketed as capsule and tablet, per the FDA's National Drug Code Directory.

What class of drug is Periostat?

Periostat is classified as tetracycline-class drug, per the FDA's Established Pharmacologic Class.

Is Periostat FDA-registered?

Periostat is on record with the U.S. FDA under application number NDA050744. You can verify this on its official FDA label.