arestin
Arestin (Minocycline Hydrochloride) is a tetracycline-class drug used to treat Acne Vulgaris, Anthrax, Borrelia Infections, Chancroid.
Minocycline Hydrochloride · by Orapharma
Key facts
- Active ingredient
- Minocycline Hydrochloride
- Drug class
- Tetracycline-Class Drug
- Form
- Powder
- Strength
- Minocycline Hydrochloride EQ 1MG Base
- Type
- Prescription (Rx)
- Brand or generic
- Brand-name
- May treat
- acne vulgaris, anthrax, borrelia infections
- Manufacturer
- Orapharma
- Half-life
- about 15.5 hours (range 11 to 22 hours) (how long it stays in your system)
- What the pharmacy pays
- ~$11.02 for 30 — not your price
- FDA application
- NDA050781
What is Arestin?
From the FDA label:ARESTIN (minocycline hydrochloride) microspheres, 1 mg is a subgingival sustained-release product containing the antibiotic minocycline hydrochloride incorporated into a bioresorbable polymer, Poly (glycolide-co-dl-lactide) or PGLA, for professional subgingival administration into periodontal pockets. Each unit-dose cartridge delivers minocycline hydrochloride equivalent to 1 mg of minocycline free base. The molecular formula of minocycline hydrochloride is C 23 H 27 N 3 O 7 ● HCl, and the molecular weight is 493.94. The structural formula of minocycline hydrochloride is: image-01.jpg
How to use
ARESTIN is provided as a dry powder, packaged in a unit-dose cartridge with a deformable tip (see Figure 1), which is inserted into a spring-loaded cartridge handle mechanism (see Figure 2) to administer the product. The oral health care professional removes the disposable cartridge from its pouch and connects the cartridge to the handle mechanism (see Figures 3-4 ). ARESTIN is a variable dose product, dependent on the size, shape, and number of pockets being treated. In US clinical trials, up to 122 unit-dose cartridges were used in a single visit and up to 3 treatments, at 3-month intervals, were administered in pockets with pocket depth of 5 mm or greater. The administration of ARESTIN does not require local anesthesia. Professional subgingival administration is accomplished by inserting the unit-dose cartridge to the base of the periodontal pocket and then pressing the thumb ring in the handle mechanism to expel the powder while gradually withdrawing the tip from the base of the pocket. The handle mechanism should be sterilized between patients. ARESTIN does not have to be removed, as it is bioresorbable, nor is an adhesive or dressing required. Arestin figures.jpg
Side effects
The most frequently reported non-dental, treatment-emergent adverse events in the 3 multicenter US trials were headache, infection, flu syndrome, and pain. Table 5: Adverse Events (AEs) Reported in ≥3% of the Combined Clinical Trial Population of 3 Multicenter US Trials by Treatment Group SRP Alone N=250 SRP + Vehicle N=249 SRP + ARESTIN ® N=423 Number (%) of Subjects Treatment-emergent AEs 62.4% 71.9% 68.1% Total Number of AEs 543 589 987 Periodontitis 25.6% 28.1% 16.3% Tooth Disorder 12.0% 13.7% 12.3% Tooth Caries 9.2% 11.2% 9.9% Dental Pain 8.8% 8.8% 9.9% Gingivitis 7.2% 8.8% 9.2% Headache 7.2% 11.6% 9.0% Infection 8.0% 9.6% 7.6% Stomatitis 8.4% 6.8% 6.4% Mouth Ulceration 1.6% 3.2% 5.0% Flu Syndrome 3.2% 6.4% 5.0% Pharyngitis 3.2% 1.6% 4.3% Pain 4.0% 1.2% 4.3% Dyspepsia 2.0% 0 4.0% Infection Dental 4.0% 3.6% 3.8% Mucous Membrane Disorder 2.4% 0.8% 3.3% The change in clinical attachment levels was similar across all study arms, suggesting that neither the vehicle nor ARESTIN compromise clinical attachment. Postmarketing Experience The following adverse reaction has been identified during postapproval use of minocycline products when taken orally. Because this reaction is reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Skin and subcutaneous tissue…
Warnings
Important safety information
This adverse reaction is more common during long-term use of the drugs, but has been observed following repeated short-term courses. Enamel hypoplasia has also been reported. TETRACYCLINE DRUGS, THEREFORE, SHOULD NOT BE USED IN THIS AGE GROUP, OR IN PREGNANT OR NURSING WOMEN, UNLESS THE POTENTIAL BENEFITS ARE CONSIDERED TO OUTWEIGH THE POTENTIAL RISKS. Results of animal studies indicate that tetracyclines cross the placenta, are found in fetal tissues, and can have toxic effects on the developing fetus (often related to retardation of skeletal development). Evidence of embryotoxicity has also been noted in animals treated early in pregnancy. If any tetracyclines are used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. Photosensitivity manifested by an exaggerated sunburn reaction has been observed in some individuals taking tetracyclines. Patients apt to be exposed to direct sunlight or ultraviolet light should be advised that this reaction can occur with tetracycline drugs, and treatment should be discontinued at the first evidence of skin erythema.
Who should not take Arestin
ARESTIN should not be used in any patient who has a known sensitivity to minocycline or tetracyclines.
Foods & drinks to be careful with
Well-established interactions for this medicine’s drug class, summarized from public health authorities. General information, not medical advice — always confirm with your pharmacist or the label.
Dairy, calcium, iron & antacids
Watch out for: milk and other dairy, calcium- or iron-fortified foods and supplements, and antacids.
Calcium, magnesium, and iron bind to these antibiotics in the gut and can stop them from being absorbed, making the medicine work less well.
What to do: Separate the antibiotic from dairy, supplements, and antacids by a couple of hours — take it at the interval the label or your pharmacist specifies.
Source: Tetracycline — MedlinePlus (U.S. National Library of Medicine) · Ciprofloxacin (a fluoroquinolone) — MedlinePlus (U.S. National Library of Medicine)
How long does Minocycline Hydrochloride stay in your body?
The elimination half-life of minocycline hydrochloride is about 15.5 hours (range 11 to 22 hours) — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. Per the oral capsule label, the serum half-life in normal volunteers ranged from 11.1 to 22.1 hours, averaging 15.5 hours. Kidney and liver function change it: in renal impairment the half-life is markedly prolonged (18 to 69 hours), while in hepatic impairment it ran 11 to 16 hours. Minocycline is not a prodrug and has no active metabolite that outlasts the parent. Elimination half-life is not the same as a drug-test detection window.
This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: Minocycline Hydrochloride capsule — DailyMed label (Clinical Pharmacology).
Drug class
How this class works, per Tetracycline - StatPearls - NCBI Bookshelf.
May treat (source: NIH RxClass)
See how Arestin ranks — best-rated tetracycline-class drug for:
Dosage forms
Powder
The forms currently marketed in the U.S., per the FDA National Drug Code Directory.
Ways to save
Ask for the generic
Same active ingredient, far cheaper. Is there a generic? →
Request a 90-day supply
Bulk fills usually lower the per-dose price vs monthly refills.
Use copay cards
Manufacturer copay cards & patient-assistance programs — especially for brand drugs.
Compare alternatives
A same-class option may cost less. See alternatives →
Frequently asked questions
- What does Arestin treat?
- Arestin (Minocycline Hydrochloride) may be used to treat acne vulgaris, anthrax, borrelia infections, chancroid, cholera, escherichia coli infections, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
- How does Arestin work?
- Arestin is a tetracycline-class drug. Tetracyclines slip inside bacteria and bind to the 30S part of their ribosome, the cell's protein-building machine. This blocks the bacteria from adding new amino acids, so they can't make the proteins they need to grow or multiply, letting the immune system clear the infection.
- How much does Arestin cost?
- Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $11.02 for 30, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.
- Is there a coupon or discount for Arestin?
- pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Arestin. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
- Who makes Arestin?
- Arestin is marketed by Orapharma. You can see Orapharma's full profile, rating, and other products on pharmaranks.
- Is Arestin a brand-name or generic drug?
- Arestin is a brand-name product with the active ingredient Minocycline Hydrochloride.
- Is Arestin available over the counter?
- No. Arestin is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
- What forms does Arestin come in?
- Arestin is currently marketed as powder, per the FDA's National Drug Code Directory.
- What class of drug is Arestin?
- Arestin is classified as tetracycline-class drug, per the FDA's Established Pharmacologic Class.
- Is Arestin FDA-registered?
- Arestin is on record with the U.S. FDA under application number NDA050781. You can verify this on its official FDA label.
- Is Arestin safe?
- There's no single safe-or-not verdict, and we don't yet have a composite recall-safety score for Arestin. Review its FDA-label side effects and warnings below, and always consult a licensed professional.
- What are the side effects of Arestin?
- Arestin's side effects are taken directly from its FDA label. From the label: The most frequently reported non-dental, treatment-emergent adverse events in the 3 multicenter US trials were headache, infection, flu syndrome, and pain.… Both common and serious reactions are documented in full on this page. This is general reference from the FDA, not medical advice — always consult a professional.
Clinical content sourced from the FDA label via openFDA (U.S. FDA). View the FDA label on DailyMed → Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.
Reviews
No reviews yet. Be the first to write one.
People also viewed
doryx mpc
Doxycycline Hyclate
doxycycline hyclate
Doxycycline Hyclate
doxycycline
Doxycycline
amzeeq
Minocycline Hydrochloride
emrosi
Minocycline Hydrochloride
minocin
Minocycline Hydrochloride
Compare Arestin head-to-head
More tetracycline-class drug drugs
Guides for this medication
Browse medications A–Z
Research products from A to Z, compare independent ratings, and find alternatives.