locoid

How long does Hydrocortisone Butyrate stay in your body?

The elimination half-life of hydrocortisone butyrate is about 1.5 hours — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. This is the plasma (terminal) elimination half-life; the FDA label states "The terminal half-life of hydrocortisone is about 1.5 hours following intravenous and oral dosing of hydrocortisone tablets" in healthy adults, so roughly 90% of a dose clears within about 8 hours and nearly all within ~12 hours. Hydrocortisone is not a prodrug, but its half-life measures how fast the drug leaves the blood, not how long its effects last: as a short-acting glucocorticoid its biological (tissue) effect on the body persists well beyond blood clearance, and this short plasma half-life is why oral replacement is usually dosed 2-3 times a day. Because hydrocortisone is metabolized in the liver, significant liver impairment can slow clearance; the label does not give a specific half-life adjustment for age, kidney, or liver function. Half-life is not the same as a drug-test detection window.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: ALKINDI SPRINKLE (hydrocortisone) oral granules — FDA prescribing information, DailyMed.

Frequently asked questions

What does Locoid treat?

Locoid (Hydrocortisone Butyrate) may be used to treat adrenal insufficiency, congenital adrenal hyperplasia, ulcerative colitis, contact dermatitis, facial dermatoses, foot dermatoses, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.

How does Locoid work?

Locoid is a corticosteroid. Corticosteroids mimic the body's natural stress hormone cortisol: they enter cells and bind a glucocorticoid receptor that switches off genes for inflammatory chemicals, calming swelling, redness, and an overactive immune response.

Is there a coupon or discount for Locoid?

pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Locoid. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.

Who makes Locoid?

Locoid is marketed by Bausch. You can see Bausch's full profile, rating, and other products on pharmaranks.

Is Locoid a brand-name or generic drug?

Locoid is a brand-name product with the active ingredient Hydrocortisone Butyrate.

Is Locoid available over the counter?

No. Locoid is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.

What forms does Locoid come in?

Locoid is currently marketed as topical and solution, per the FDA's National Drug Code Directory.

What class of drug is Locoid?

Locoid is classified as corticosteroid, per the FDA's Established Pharmacologic Class.

Is Locoid FDA-registered?

Locoid is on record with the U.S. FDA under application number NDA022076. You can verify this on its official FDA label.