hydrocortisone valerate

What is Hydrocortisone Valerate?

From the FDA label:Hydrocortisone Valerate Ointment USP, 0.2% contains hydrocortisone valerate, USP, pregn-4-ene-3,20-dione, 11,21-dihydroxy-17-[(1-oxopentyl)oxy]-, (11β)-;cortisol 17-valerate or 11β,17,21-Trihydroxypregn-4-ene-3,20-dione 17-valerate, a synthetic corticosteroid for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and antipruritic agents. Chemically, hydrocortisone valerate, USP is C 26 H 38 O 6 . It has the following structural formula: Hydrocortisone valerate, USP has a molecular weight of 446.58. It is a white or almost white crystalline powder, freely soluble in acetone and dichloromethane; soluble in alcohol; insoluble in water. Each gram of Hydrocortisone Valerate Ointment, USP, 0.2% contains 2 mg hydrocortisone valerate, USP in a hydrophilic base composed of citric acid monohydrate, methyl paraben, mineral oil, polyoxyl stearyl ether, propylene glycol, sepineo P 600, steareth 100, stearyl alcohol, sodium lauryl sulfate, white petrolatum and purified water. structure

How to use

Side effects

Who should not take Hydrocortisone Valerate

Overdose — what happens if you take too much

How long does Hydrocortisone Valerate stay in your body?

The elimination half-life of hydrocortisone valerate is about 1.5 hours — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. This is the plasma (terminal) elimination half-life; the FDA label states "The terminal half-life of hydrocortisone is about 1.5 hours following intravenous and oral dosing of hydrocortisone tablets" in healthy adults, so roughly 90% of a dose clears within about 8 hours and nearly all within ~12 hours. Hydrocortisone is not a prodrug, but its half-life measures how fast the drug leaves the blood, not how long its effects last: as a short-acting glucocorticoid its biological (tissue) effect on the body persists well beyond blood clearance, and this short plasma half-life is why oral replacement is usually dosed 2-3 times a day. Because hydrocortisone is metabolized in the liver, significant liver impairment can slow clearance; the label does not give a specific half-life adjustment for age, kidney, or liver function. Half-life is not the same as a drug-test detection window.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: ALKINDI SPRINKLE (hydrocortisone) oral granules — FDA prescribing information, DailyMed.

Frequently asked questions

What does Hydrocortisone Valerate treat?

Hydrocortisone Valerate (Hydrocortisone Valerate) may be used to treat adrenal insufficiency, congenital adrenal hyperplasia, ulcerative colitis, contact dermatitis, facial dermatoses, foot dermatoses, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.

How does Hydrocortisone Valerate work?

Hydrocortisone Valerate is a corticosteroid. Corticosteroids mimic the body's natural stress hormone cortisol: they enter cells and bind a glucocorticoid receptor that switches off genes for inflammatory chemicals, calming swelling, redness, and an overactive immune response.

How is Hydrocortisone Valerate rated?

pharmaranks gives Hydrocortisone Valerate a composite score of 3.1 out of 5, currently based on 1 weighted source (FDA regulatory recall-safety data weighted highest). See our methodology at /how-we-rate.

Is there a coupon or discount for Hydrocortisone Valerate?

pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Hydrocortisone Valerate. To pay less, Hydrocortisone Valerate is already a generic — usually the lowest-cost version — so the main levers are comparing cash prices between pharmacies and using a pharmacy discount-card service. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.

Who makes Hydrocortisone Valerate?

Hydrocortisone Valerate is marketed by Glenmark Pharms Ltd. You can see Glenmark Pharms Ltd's full profile, rating, and other products on pharmaranks.

Is Hydrocortisone Valerate a brand-name or generic drug?

Hydrocortisone Valerate is a generic medication; its active ingredient is Hydrocortisone Valerate. Generics contain the same active ingredient as the brand-name original and are usually lower cost.

Is Hydrocortisone Valerate available over the counter?

No. Hydrocortisone Valerate is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.

What forms does Hydrocortisone Valerate come in?

Hydrocortisone Valerate is currently marketed as topical, per the FDA's National Drug Code Directory.

What class of drug is Hydrocortisone Valerate?

Hydrocortisone Valerate is classified as corticosteroid, per the FDA's Established Pharmacologic Class.

Is Hydrocortisone Valerate FDA-registered?

Hydrocortisone Valerate is on record with the U.S. FDA under application number ANDA211750. You can verify this on its official FDA label.

Has Hydrocortisone Valerate been recalled by the FDA?

Hydrocortisone Valerate has no FDA recalls recorded under its own application in the openFDA enforcement database. Its recall-safety score reflects its manufacturer's overall recall record. This is general reference, not medical advice — check the FDA recall database for the latest alerts.

Is Hydrocortisone Valerate safe?

There's no single safe-or-not verdict. pharmaranks gives Hydrocortisone Valerate a recall-safety score of 62/100, based on its FDA recall history (no recalls under its own FDA application) — not an efficacy or side-effect rating. Review its FDA-label side effects and warnings before use, and always consult a licensed professional.

What are the side effects of Hydrocortisone Valerate?

Hydrocortisone Valerate's side effects are taken directly from its FDA label. From the label: In controlled clinical trials, the total incidence of adverse reactions associated with the use of hydrocortisone valerate ointment, 0.2% was approximately 12%. These included worsening of condition (2%), transient itching (2%), irritation (1%) and redness (1%).… Both common and serious reactions are documented in full on this page. This is general reference from the FDA, not medical advice — always consult a professional.