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doryx

Pharmaranks rates Doryx 3.5/5 for recall safety — an independent score from its FDA recall history and its manufacturer's record. Doryx (Doxycycline Hyclate) is a tetracycline-class drug used to treat Anthrax, Campylobacter Infections, Cholera, Granuloma Inguinale.

Doxycycline Hyclate · by Mayne Pharma

Available as a generic: Doxycycline Hyclate

70/100Limited · 1 source

Based on 1 source · Recall-safety score from FDA recall history — this product's own recalls and its manufacturer's record. Not an efficacy or quality rating. methodology →

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate
Verified againstopenFDANIH DailyMedRxClass

Key facts

Active ingredient
Doxycycline Hyclate
Form
Tablet, delayed release, Capsule, delayed release
Strength
Doxycycline Hyclate EQ 100MG Base · Doxycycline Hyclate EQ 75MG Base
Type
Prescription (Rx)
Brand or generic
Brand-name
Manufacturer
Mayne Pharma
Half-life
about 16 to 22 hours in healthy adults (how long it stays in your system)
What the pharmacy pays
~$0.12 per ml — not your price
FDA application
NDA050582
Availability
Discontinued (per FDA)

Foods & drinks to be careful with

Well-established interactions for this medicine’s drug class, summarized from public health authorities. General information, not medical advice — always confirm with your pharmacist or the label.

How long does Doxycycline Hyclate stay in your body?

The elimination half-life of doxycycline hyclate is about 16 to 22 hours in healthy adults — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. This is the elimination half-life of doxycycline itself; it has no active metabolite with a longer half-life, and the half-life stays about the same (18 to 22 hours) even with severe kidney impairment and is not shortened by hemodialysis.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: DOXYCYCLINE MONOHYDRATE capsule — DailyMed (Clinical Pharmacology / Pharmacokinetics).

Drug class

How this class works, per Tetracycline - StatPearls - NCBI Bookshelf.

May treat (source: NIH RxClass)

See how Doryx ranks — best-rated tetracycline-class drug for:

Dosage forms

Tablet, delayed release and Capsule, delayed release

The forms currently marketed in the U.S., per the FDA National Drug Code Directory.

Ways to save

Ask for the generic

Same active ingredient, far cheaper. Is there a generic? →

Request a 90-day supply

Bulk fills usually lower the per-dose price vs monthly refills.

Use copay cards

Manufacturer copay cards & patient-assistance programs — especially for brand drugs.

Compare alternatives

A same-class option may cost less. See alternatives →

Frequently asked questions

What does Doryx treat?
Doryx (Doxycycline Hyclate) may be used to treat anthrax, campylobacter infections, cholera, granuloma inguinale, mycoplasma infections, psittacosis, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
How does Doryx work?
Doryx is a tetracycline-class drug. Tetracyclines slip inside bacteria and bind to the 30S part of their ribosome, the cell's protein-building machine. This blocks the bacteria from adding new amino acids, so they can't make the proteins they need to grow or multiply, letting the immune system clear the infection.
How is Doryx rated?
pharmaranks gives Doryx a composite score of 3.5 out of 5, currently based on 1 weighted source (FDA regulatory recall-safety data weighted highest). See our methodology at /how-we-rate.
How much does Doryx cost?
Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $0.12 per ml, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.
Is there a coupon or discount for Doryx?
pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Doryx. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
Who makes Doryx?
Doryx is marketed by Mayne Pharma. You can see Mayne Pharma's full profile, rating, and other products on pharmaranks.
Is Doryx a brand-name or generic drug?
Doryx is a brand-name product with the active ingredient Doxycycline Hyclate. Lower-cost generic equivalents containing Doxycycline Hyclate are available — ask your pharmacist.
Is Doryx available over the counter?
No. Doryx is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
What forms does Doryx come in?
Doryx is currently marketed as tablet, delayed release and capsule, delayed release, per the FDA's National Drug Code Directory.
What class of drug is Doryx?
Doryx is classified as tetracycline-class drug, per the FDA's Established Pharmacologic Class.
Is Doryx FDA-registered?
Doryx is on record with the U.S. FDA under application number NDA050582. You can verify this on its official FDA label.
Has Doryx been recalled by the FDA?
Doryx has no FDA recalls recorded under its own application in the openFDA enforcement database. Its recall-safety score reflects its manufacturer's overall recall record. This is general reference, not medical advice — check the FDA recall database for the latest alerts.
Is Doryx safe?
There's no single safe-or-not verdict. pharmaranks gives Doryx a recall-safety score of 70/100, based on its FDA recall history (no recalls under its own FDA application) — not an efficacy or side-effect rating. Review its FDA-label side effects and warnings before use, and always consult a licensed professional.

Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.

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