DORYX vs DOXYCYCLINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. DORYX and DOXYCYCLINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DORYX	DOXYCYCLINE
Rating	70/100	64/100
Pharmacy pays	$0.12 /mL	$0.12 /mL
Type	RX	RX
Active ingredient	DOXYCYCLINE HYCLATE	DOXYCYCLINE
Manufacturer	Mayne Pharma	Lupin
Dosage forms	Tablet, delayed release, Capsule, delayed release	Capsule, Injectable
Drug class	Tetracycline-Class Drug	Tetracycline-Class Drug
Boxed warning	None	None
Half-life	about 16 to 22 hours in healthy adults	about 16 to 22 hours in healthy adults
Treats	Anthrax, Campylobacter Infections, Cholera	Anthrax, Campylobacter Infections, Cholera

doryx doxycycline

Rating

70/100

64/100

Pharmacy pays

$0.12 /mL

Type

Active ingredient

DOXYCYCLINE HYCLATE

DOXYCYCLINE

Manufacturer

Mayne Pharma

Lupin

Dosage forms

Tablet, delayed release, Capsule, delayed release

Capsule, Injectable

Drug class

Tetracycline-Class Drug

Boxed warning

None

Half-life

about 16 to 22 hours in healthy adults

Treats

Anthrax, Campylobacter Infections, Cholera

Frequently asked questions

Which is better-rated, Doryx or Doxycycline?

By our independent rating, Doryx scores higher — 3.5 vs 3.2 out of 5 for Doxycycline. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Doryx or Doxycycline?

Pharmacies pay about the same to acquire either one — roughly $0.12 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Doryx and Doxycycline?

Doryx contains Doxycycline Hyclate, while Doxycycline contains Doxycycline — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.