aleve pm
Aleve Pm is a combination medicine containing Diphenhydramine Hydrochloride and Naproxen Sodium.
Diphenhydramine Hydrochloride and Naproxen Sodium · by Bayer Hlthcare
Key facts
- Active ingredient
- Diphenhydramine Hydrochloride and Naproxen Sodium
- Form
- Tablet
- Strength
- Diphenhydramine Hydrochloride 25MG; Naproxen Sodium 220MG
- Type
- Over-the-counter (OTC)
- Brand or generic
- Brand-name
- Manufacturer
- Bayer Hlthcare
- Half-life
- about 12 to 17 hours (how long it stays in your system)
- What the pharmacy pays
- ~$0.04 per ml — not your price
- FDA application
- NDA205352
What is Aleve Pm?
From the FDA label:Uses for relief of occasional sleeplessness when associated with minor aches and pains helps you fall asleep and stay asleep
How to use
Directions do not take more than directed drink a full glass of water with each dose adults and children 12 years and over: take 2 caplets at bedtime do not take more than 2 caplets in 24 hours if taken with food, this product may take longer to work
Warnings
Important safety information
Allergy alert Naproxen sodium may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include: hives facial swelling asthma (wheezing) shock skin reddening rash blisters If an allergic reaction occurs, stop use and seek medical help right away. Stomach bleeding warning This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you: are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) have 3 or more alcoholic drinks every day while using this product take more or for a longer time than directed Heart attack and stroke warning NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke. These can be fatal. The risk is higher if you use more than directed or for longer than directed. Do not use if you have ever had an allergic reaction to any other pain reliever/fever reducer unless you have time for a full night's sleep in children under 12 years of age right before or after heart surgery with any other product containing diphenhydramine, even one used on skin if you have sleeplessness without pain Ask a doctor before use if stomach bleeding warning applies to you you have problems or serious side effects from taking pain relievers or fever reducers you have a history of stomach problems, such as heartburn you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma or had a stroke you are taking a diuretic you have a breathing problem such as emphysema or chronic bronchitis you have glaucoma you have trouble urinating due to an enlarged prostate gland Ask a doctor or pharmacist before use if you are taking sedatives or tranquilizers, or any other sleep-aid under a doctor's care for any serious condition taking aspirin for heart attack or stroke, because naproxen may decrease this benefit of aspirin taking any other antihistamines taking any other drug When using this product drowsiness will occur avoid alcoholic drinks do not drive a motor vehicle or operate machinery take with food or milk if stomach upset occurs Stop use and ask a doctor if you experience any of the following signs of stomach bleeding: feel faint vomit blood have bloody or black stools have stomach pain that does not get better you have symptoms of heart problems or stroke: chest pain trouble breathing weakness in one part or side of body slurred speech leg swelling pain gets worse or lasts more than 10 days sleeplessness persists continuously for more than 2 weeks. Insomnia may be a symptom of a serious underlying medical illness. redness or swelling is present in the painful area any new symptoms appear you have difficulty swallowing it feels like the pill is stuck in your throat If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use naproxen sodium 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.
How long does Diphenhydramine Hydrochloride and Naproxen Sodium stay in your body?
The elimination half-life of diphenhydramine hydrochloride and naproxen sodium is about 12 to 17 hours — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. This is naproxen's elimination (terminal) half-life in healthy adults; its metabolites have shorter half-lives, so there is no longer-acting active metabolite to account for. The half-life is prolonged in severe renal impairment, and above 500 mg/day the drug shows nonlinear (dose-dependent) kinetics because plasma protein binding becomes saturated.
This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: NAPROXEN tablet, delayed release — DailyMed (FDA label).
Dosage forms
Tablet
The forms currently marketed in the U.S., per the FDA National Drug Code Directory.
Ways to save
Ask for the generic
Same active ingredient, far cheaper. Is there a generic? →
Request a 90-day supply
Bulk fills usually lower the per-dose price vs monthly refills.
Use copay cards
Manufacturer copay cards & patient-assistance programs — especially for brand drugs.
Compare alternatives
A same-class option may cost less. See alternatives →
Frequently asked questions
- How much does Aleve Pm cost?
- Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $0.04 per ml, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.
- Is there a coupon or discount for Aleve Pm?
- pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Aleve Pm. To pay less, look for a store-brand version with the same active ingredient (Diphenhydramine Hydrochloride and Naproxen Sodium), which is typically cheaper, and compare unit prices. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
- Who makes Aleve Pm?
- Aleve Pm is marketed by Bayer Hlthcare. You can see Bayer Hlthcare's full profile, rating, and other products on pharmaranks.
- Is Aleve Pm a brand-name or generic drug?
- Aleve Pm is a brand-name product with the active ingredient Diphenhydramine Hydrochloride and Naproxen Sodium.
- Is Aleve Pm available over the counter?
- Yes. Aleve Pm is an over-the-counter (OTC) product — you can buy it without a prescription. Follow the label directions and ask a pharmacist if you're unsure whether it's right for you.
- What forms does Aleve Pm come in?
- Aleve Pm is currently marketed as tablet, per the FDA's National Drug Code Directory.
- Is Aleve Pm FDA-registered?
- Aleve Pm is on record with the U.S. FDA under application number NDA205352. You can verify this on its official FDA label.
- Is Aleve Pm safe?
- There's no single safe-or-not verdict, and we don't yet have a composite recall-safety score for Aleve Pm. Review its FDA-label side effects and warnings below, and always consult a licensed professional.
Clinical content sourced from the FDA label via openFDA (U.S. FDA). View the FDA label on DailyMed → Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.
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