ADVIL COLD AND SINUS vs ALEVE PM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Attribute	ADVIL COLD AND SINUS	ALEVE PM
Rating	72/100	New
Pharmacy pays	$0.04 /mL	$0.04 /mL
Type	OTC	OTC
Active ingredient	IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE	DIPHENHYDRAMINE HYDROCHLORIDE AND NAPROXEN SODIUM
Manufacturer	Haleon US Holdings	Bayer Hlthcare
Dosage forms	Capsule, Tablet	Tablet
Drug class	—	—
Boxed warning	None	None
Half-life	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)	about 12 to 17 hours

advil cold and sinus aleve pm

Rating

72/100

New

Pharmacy pays

$0.04 /mL

Type

OTC

Active ingredient

IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE

DIPHENHYDRAMINE HYDROCHLORIDE AND NAPROXEN SODIUM

Manufacturer

Haleon US Holdings

Bayer Hlthcare

Dosage forms

Capsule, Tablet

Tablet

Drug class

—

Boxed warning

None

Half-life

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

about 12 to 17 hours

Get advil cold and sinushigher-rated option

Advertising disclosure: Some links are affiliate links. We may earn a commission at no extra cost to you. This never affects our independent ratings.

Where to buy

Buy over-the-counter from trusted retailers.

AmazonCheck price on Amazon

Frequently asked questions

Which is cheaper, Advil Cold and Sinus or Aleve Pm?

Aleve Pm costs pharmacies less to acquire — about $0.04 vs $0.04 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Advil Cold and Sinus and Aleve Pm?

Advil Cold and Sinus contains Ibuprofen and Pseudoephedrine Hydrochloride, while Aleve Pm contains Diphenhydramine Hydrochloride and Naproxen Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.