ADVIL ALLERGY SINUS vs ALEVE PM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 13, 2026·How we rate

Attribute	ADVIL ALLERGY SINUS	ALEVE PM
Rating	72/100	New
Pharmacy pays	—	$0.04 /mL
Type	OTC	OTC
Active ingredient	CHLORPHENIRAMINE MALEATE AND IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE	DIPHENHYDRAMINE HYDROCHLORIDE AND NAPROXEN SODIUM
Manufacturer	Haleon US Holdings	Bayer Hlthcare
Dosage forms	Tablet	Tablet
Drug class	—	—
Boxed warning	None	None
Half-life	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)	about 12 to 17 hours

advil allergy sinus aleve pm

Rating

72/100

New

Pharmacy pays

—

$0.04 /mL

Type

OTC

Active ingredient

CHLORPHENIRAMINE MALEATE AND IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE

DIPHENHYDRAMINE HYDROCHLORIDE AND NAPROXEN SODIUM

Manufacturer

Haleon US Holdings

Bayer Hlthcare

Dosage forms

Tablet

Drug class

—

Boxed warning

None

Half-life

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

about 12 to 17 hours

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Frequently asked questions

What is the difference between Advil Allergy Sinus and Aleve Pm?

Advil Allergy Sinus contains Chlorpheniramine Maleate and Ibuprofen and Pseudoephedrine Hydrochloride, while Aleve Pm contains Diphenhydramine Hydrochloride and Naproxen Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.