Atypical antipsychotics compared

Compare all 29 atypical antipsychotics side by side, used for conditions such as schizophrenia, bipolar disorder, tourette syndrome. Atypical antipsychotics are the Atypical Antipsychotic class. They share one FDA-defined mechanism but differ in approved uses, prescription status, brand-vs-generic options, price, and FDA recall-safety record — which our independent rating scores. The highest-rated is aristada.

Top-rated atypical antipsychotic: 1. Aristada · 2. Aristada Initio Kit · 3. Asenapine Maleate

Atypical Antipsychotic drugs compared side by side, with pharmaranks' FDA recall-safety rating
Drug	Generic	Form	Status	Used for	Safety ratingFDA recall-based	Pharmacy pays
Aristada	Aripiprazole Lauroxil	Injectable	Prescription	Schizophrenia	70/100	—
Aristada Initio Kit	Aripiprazole Lauroxil	Injectable	Prescription	Schizophrenia	70/100	—
Asenapine Maleate	—	Tablet	Prescription	Bipolar Disorder, Schizophrenia	70/100	$74
Geodon	Ziprasidone Hydrochloride	Capsule	Prescription	Tourette Syndrome, Schizophrenia	70/100	$9
Invega	Paliperidone	Tablet	Prescription	Bipolar Disorder, Depressive Disorder	70/100	$33
Invega Hafyera	Paliperidone Palmitate	Injectable	Prescription	Bipolar Disorder, Depressive Disorder	70/100	—
Invega Sustenna	Paliperidone Palmitate	Injectable	Prescription	Bipolar Disorder, Depressive Disorder	70/100	—
Invega Trinza	Paliperidone Palmitate	Injectable	Prescription	Bipolar Disorder, Depressive Disorder	70/100	—
Risperdal	Risperidone	Solution	Prescription	Autistic Disorder, Bipolar Disorder	70/100	$2
Saphris	Asenapine Maleate	Tablet	Prescription	Bipolar Disorder, Schizophrenia	70/100	$74
Uzedy	Risperidone	Injectable	Prescription	Autistic Disorder, Bipolar Disorder	56/100	$2
Abilify Asimtufii	Aripiprazole	Injectable	Prescription	Schizophrenia	Not yet rated	$0

The safety rating column is unique to pharmaranks — an independent 0–100 score from FDA regulatory recall data. Higher is safer. Not medical advice.

Best atypical antipsychotic by condition

for schizophrenia for bipolar disorder for tourette syndrome for depressive disorder for autistic disorder for dementia

Full ranking · 29 drugs

Frequently asked questions

What is the Atypical Antipsychotic drug class?

Atypical Antipsychotic is an FDA Established Pharmacologic Class (EPC) — a group of drugs that share a mechanism of action. pharmaranks lists 29 Atypical Antipsychotic products, each independently rated.

Are all Atypical Antipsychotic drugs the same?

No. Atypical Antipsychotic drugs share the same core mechanism — that is why they sit in one FDA class — but they differ in their approved uses, available forms, whether they are prescription or over-the-counter, brand-vs-generic options and price, and their FDA recall-safety record.

Is "atypical antipsychotics" the same as the Atypical Antipsychotic class?

Yes — "atypical antipsychotics" is the everyday name for the Atypical Antipsychotic drug class. This page compares the 29 atypical antipsychotics pharmaranks rates, with our independent FDA recall-safety score for each.

What conditions do Atypical Antipsychotic drugs treat?

Per NIH RxClass drug-classification data, Atypical Antipsychotic drugs are used for conditions including schizophrenia, bipolar disorder, tourette syndrome, depressive disorder, autistic disorder, dementia.

Which Atypical Antipsychotic drug is best-rated?

By our independent rating, aristada currently ranks highest among Atypical Antipsychotic drugs. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.

Sources: the Atypical Antipsychotic class definition and its member drugs come from the U.S. NLM RxClass (Established Pharmacologic Class); how the class works is summarized from Atypical Antipsychotic Agents - StatPearls - NCBI Bookshelf. Ratings are pharmaranks’ independent FDA recall-safety analysis.