Best Atypical Antipsychotic for bipolar disorder
Top-rated pick: Asenapine Maleate — pharmaranks score 70/100, the highest of the 21 Atypical Antipsychotic drugs used for bipolar disorder, ranked by our independent FDA recall-safety score. Compare them with all treatments for bipolar disorder or the full Atypical Antipsychotic class. Not medical advice — always consult a professional.
Quick answer: Of the 21 atypical antipsychotic drugs we rate for bipolar disorder, 17 are available as lower-cost generics, and most are tablet. Our ranking reflects each drug’s FDA recall-safety record — not clinical effectiveness for bipolar disorder; the right choice depends on your situation, so confirm it with your prescriber.
How atypical antipsychotic work
Atypical antipsychotics block dopamine D2 receptors and serotonin 5-HT2A receptors in the brain, rebalancing these signaling chemicals to reduce hallucinations, delusions, and mood symptoms in conditions like schizophrenia and bipolar disorder.
Source: Atypical Antipsychotic Agents - StatPearls - NCBI Bookshelf
Other drug classes for bipolar disorder
Top atypical antipsychotic for bipolar disorder: 1. Asenapine Maleate · 2. Invega · 3. Invega Hafyera
| # | Drug | Rating | Type | Form | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|
| 1 | 70/100 | Prescription | Tablet | Generic | $74 | View → | |
| 2 | 70/100 | Prescription | Tablet | Generic | $33 | View → | |
| 3 | 70/100 | Prescription | Injectable | No data | — | View → | |
| 4 | 70/100 | Prescription | Injectable | No data | — | View → | |
| 5 | 70/100 | Prescription | Injectable | No data | — | View → | |
| 6 | 70/100 | Prescription | Solution | Generic | $2 | View → | |
| 7 | 70/100 | Prescription | Tablet | Generic | $74 | View → | |
| 8 | 56/100 | Prescription | Injectable | Generic | $2 | View → | |
| 9 | Not yet rated | Prescription | Tablet | Generic | $31 | View → | |
| 10 | Not yet rated | Prescription | Injectable | No data | — | View → |
Full ranking · 21 drugs
asenapine maleate
Boxed warningPrescriptionFDA-sourced
Asenapine Maleate is an atypical antipsychotic used to treat Bipolar Disorder, Schizophrenia.
Pharmacy pays
From ~$69.80/30· 3 forms Save up to 97% in classinvega
Boxed warningPrescriptionFDA-sourced
Invega (Paliperidone) is an atypical antipsychotic used to treat Bipolar Disorder, Depressive Disorder, Schizophrenia.
Pharmacy pays
From ~$28.84/30· 4 forms Save up to 94% in classinvega hafyera
Boxed warningPrescriptionFDA-sourced
Invega Hafyera (Paliperidone Palmitate) is an atypical antipsychotic used to treat Bipolar Disorder, Depressive Disorder, Schizophrenia.
invega sustenna
Boxed warningPrescriptionFDA-sourced
Invega Sustenna (Paliperidone Palmitate) is an atypical antipsychotic used to treat Bipolar Disorder, Depressive Disorder, Schizophrenia.
invega trinza
Boxed warningPrescriptionFDA-sourced
Invega Trinza (Paliperidone Palmitate) is an atypical antipsychotic used to treat Bipolar Disorder, Depressive Disorder, Schizophrenia.
risperdal
Boxed warningPrescriptionFDA-sourced
Risperdal (Risperidone) is an atypical antipsychotic used to treat Autistic Disorder, Bipolar Disorder, Dementia, Tourette Syndrome.
Pharmacy pays
From ~$1.07/30· 8 forms
saphris
Boxed warningPrescriptionFDA-sourced
Saphris (Asenapine Maleate) is an atypical antipsychotic used to treat Bipolar Disorder, Schizophrenia.
Pharmacy pays
From ~$69.80/30· 3 forms Save up to 97% in classuzedy
Boxed warningPrescriptionFDA-sourced
Uzedy (Risperidone) is an atypical antipsychotic used to treat Autistic Disorder, Bipolar Disorder, Dementia, Tourette Syndrome.
Pharmacy pays
From ~$1.07/30· 8 formsclozaril
Boxed warningPrescriptionFDA-sourced
Clozaril (Clozapine) is an atypical antipsychotic used to treat Bipolar Disorder, Psychotic Disorders, Schizophrenia.
Pharmacy pays
From ~$7.63/30· 8 forms Save up to 93% in classerzofri
Boxed warningPrescriptionFDA-sourced
Erzofri (Paliperidone Palmitate) is an atypical antipsychotic used to treat Bipolar Disorder, Depressive Disorder, Schizophrenia.
latuda
Boxed warningPrescriptionFDA-sourced
Latuda (Lurasidone Hydrochloride) is an atypical antipsychotic used to treat Bipolar Disorder, Major Depressive Disorder, Schizophrenia.
Pharmacy pays
From ~$4.19/30· 5 forms Save up to 78% in classlurasidone hydrochloride
Boxed warningPrescriptionFDA-sourced
Lurasidone Hydrochloride is an atypical antipsychotic used to treat Bipolar Disorder, Major Depressive Disorder, Schizophrenia.
Pharmacy pays
From ~$4.19/30· 5 forms Save up to 78% in classpaliperidone
Boxed warningPrescriptionFDA-sourced
Paliperidone is an atypical antipsychotic used to treat Bipolar Disorder, Depressive Disorder, Schizophrenia.
Pharmacy pays
From ~$28.84/30· 4 forms Save up to 94% in classquetiapine fumarate
PrescriptionFDA-sourced
Quetiapine Fumarate is an atypical antipsychotic used to treat Autistic Disorder, Bipolar Disorder, Major Depressive Disorder, Psychotic Disorders.
Pharmacy pays
From ~$0.87/30· 8 forms Save up to 21% in classrykindo
Boxed warningPrescriptionFDA-sourced
Rykindo (Risperidone) is an atypical antipsychotic used to treat Autistic Disorder, Bipolar Disorder, Dementia, Tourette Syndrome.
Pharmacy pays
From ~$1.07/30· 8 formssecuado
Boxed warningPrescriptionFDA-sourced
Secuado (Asenapine) is an atypical antipsychotic used to treat Bipolar Disorder, Schizophrenia.
Pharmacy pays
From ~$69.80/30· 3 forms Save up to 97% in classseroquel
Boxed warningPrescriptionFDA-sourced
Seroquel (Quetiapine Fumarate) is an atypical antipsychotic used to treat Autistic Disorder, Bipolar Disorder, Major Depressive Disorder, Psychotic Disorders.
Pharmacy pays
From ~$0.87/30· 8 forms Save up to 21% in class
seroquel xr
PrescriptionFDA-sourced
Seroquel XR (Quetiapine Fumarate) is an atypical antipsychotic used to treat Autistic Disorder, Bipolar Disorder, Major Depressive Disorder, Psychotic Disorders.
Pharmacy pays
From ~$0.87/30· 8 forms Save up to 21% in classversacloz
Boxed warningPrescriptionFDA-sourced
Versacloz (Clozapine) is an atypical antipsychotic used to treat Bipolar Disorder, Psychotic Disorders, Schizophrenia.
Pharmacy pays
From ~$7.63/30· 8 forms Save up to 93% in classzyprexa
Boxed warningPrescriptionFDA-sourced
Zyprexa (Olanzapine) is an atypical antipsychotic used to treat Bipolar Disorder, Psychotic Disorders, Schizophrenia.
Pharmacy pays
From ~$2.40/30· 8 forms Save up to 50% in classzyprexa zydis
Boxed warningPrescriptionFDA-sourced
Zyprexa Zydis (Olanzapine) is an atypical antipsychotic used to treat Bipolar Disorder, Psychotic Disorders, Schizophrenia.
Pharmacy pays
From ~$2.40/30· 8 forms Save up to 50% in classFrequently asked
- What is the best atypical antipsychotic for bipolar disorder?
- By our independent recall-safety rating — not an efficacy measure — asenapine maleate ranks highest among Atypical Antipsychotic drugs used for bipolar disorder. Always consult a professional.
- Which atypical antipsychotic drugs treat bipolar disorder?
- pharmaranks lists 21 Atypical Antipsychotic products used for bipolar disorder, per NIH RxClass drug-classification data — each independently rated and ranked above.
- How are these ranked?
- By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.