Best Atypical Antipsychotic for schizophrenia
Top-rated pick: Aristada — pharmaranks score 70/100, the highest of the 29 Atypical Antipsychotic drugs used for schizophrenia, ranked by our independent FDA recall-safety score. Compare them with all treatments for schizophrenia or the full Atypical Antipsychotic class. Not medical advice — always consult a professional.
Quick answer: Of the 29 atypical antipsychotic drugs we rate for schizophrenia, 16 are available as lower-cost generics, and most are tablet. Our ranking reflects each drug’s FDA recall-safety record — not clinical effectiveness for schizophrenia; the right choice depends on your situation, so confirm it with your prescriber.
How atypical antipsychotic work
Atypical antipsychotics block dopamine D2 receptors and serotonin 5-HT2A receptors in the brain, rebalancing these signaling chemicals to reduce hallucinations, delusions, and mood symptoms in conditions like schizophrenia and bipolar disorder.
Source: Atypical Antipsychotic Agents - StatPearls - NCBI Bookshelf
Other drug classes for schizophrenia
Top atypical antipsychotic for schizophrenia: 1. Aristada · 2. Aristada Initio Kit · 3. Asenapine Maleate
| # | Drug | Rating | Type | Form | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|
| 1 | 70/100 | Prescription | Injectable | No data | — | View → | |
| 2 | 70/100 | Prescription | Injectable | No data | — | View → | |
| 3 | 70/100 | Prescription | Tablet | Generic | $74 | View → | |
| 4 | 70/100 | Prescription | Capsule | Generic | $9 | View → | |
| 5 | 70/100 | Prescription | Tablet | Generic | $33 | View → | |
| 6 | 70/100 | Prescription | Injectable | No data | — | View → | |
| 7 | 70/100 | Prescription | Injectable | No data | — | View → | |
| 8 | 70/100 | Prescription | Injectable | No data | — | View → | |
| 9 | 70/100 | Prescription | Solution | Generic | $2 | View → | |
| 10 | 70/100 | Prescription | Tablet | Generic | $74 | View → |
Full ranking · 29 drugs
aristada
Boxed warningPrescriptionFDA-sourced
Aristada (Aripiprazole Lauroxil) is an atypical antipsychotic used to treat Schizophrenia.
Price varies
aristada initio kit
Boxed warningPrescriptionFDA-sourced
Aristada Initio Kit (Aripiprazole Lauroxil) is an atypical antipsychotic used to treat Schizophrenia.
Price varies
asenapine maleate
Boxed warningPrescriptionFDA-sourced
Asenapine Maleate is an atypical antipsychotic used to treat Bipolar Disorder, Schizophrenia.
Pharmacy pays
From ~$69.80/30· 3 forms Save up to 97% in class
geodon
Boxed warningPrescriptionFDA-sourced
Geodon (Ziprasidone Hydrochloride) is an atypical antipsychotic used to treat Tourette Syndrome, Schizophrenia.
Pharmacy pays
From ~$8.21/30· 5 forms Save up to 78% in classinvega
Boxed warningPrescriptionFDA-sourced
Invega (Paliperidone) is an atypical antipsychotic used to treat Bipolar Disorder, Depressive Disorder, Schizophrenia.
Pharmacy pays
From ~$28.84/30· 4 forms Save up to 94% in classinvega hafyera
Boxed warningPrescriptionFDA-sourced
Invega Hafyera (Paliperidone Palmitate) is an atypical antipsychotic used to treat Bipolar Disorder, Depressive Disorder, Schizophrenia.
invega sustenna
Boxed warningPrescriptionFDA-sourced
Invega Sustenna (Paliperidone Palmitate) is an atypical antipsychotic used to treat Bipolar Disorder, Depressive Disorder, Schizophrenia.
invega trinza
Boxed warningPrescriptionFDA-sourced
Invega Trinza (Paliperidone Palmitate) is an atypical antipsychotic used to treat Bipolar Disorder, Depressive Disorder, Schizophrenia.
risperdal
Boxed warningPrescriptionFDA-sourced
Risperdal (Risperidone) is an atypical antipsychotic used to treat Autistic Disorder, Bipolar Disorder, Dementia, Tourette Syndrome.
Pharmacy pays
From ~$1.07/30· 8 forms
saphris
Boxed warningPrescriptionFDA-sourced
Saphris (Asenapine Maleate) is an atypical antipsychotic used to treat Bipolar Disorder, Schizophrenia.
Pharmacy pays
From ~$69.80/30· 3 forms Save up to 97% in classuzedy
Boxed warningPrescriptionFDA-sourced
Uzedy (Risperidone) is an atypical antipsychotic used to treat Autistic Disorder, Bipolar Disorder, Dementia, Tourette Syndrome.
Pharmacy pays
From ~$1.07/30· 8 forms
abilify asimtufii
Boxed warningPrescriptionFDA-sourced
Abilify Asimtufii (Aripiprazole) is an atypical antipsychotic used to treat Schizophrenia.
Pharmacy pays
From ~$0.10· 8 formsabilify maintena kit
Boxed warningPrescriptionFDA-sourced
Abilify Maintena Kit (Aripiprazole) is an atypical antipsychotic used to treat Schizophrenia.
Pharmacy pays
From ~$0.10· 8 formsclozaril
Boxed warningPrescriptionFDA-sourced
Clozaril (Clozapine) is an atypical antipsychotic used to treat Bipolar Disorder, Psychotic Disorders, Schizophrenia.
Pharmacy pays
From ~$7.63/30· 8 forms Save up to 93% in classerzofri
Boxed warningPrescriptionFDA-sourced
Erzofri (Paliperidone Palmitate) is an atypical antipsychotic used to treat Bipolar Disorder, Depressive Disorder, Schizophrenia.
fanapt
Boxed warningPrescriptionFDA-sourced
Fanapt (Iloperidone) is an atypical antipsychotic used to treat Schizophrenia.
Price varies
latuda
Boxed warningPrescriptionFDA-sourced
Latuda (Lurasidone Hydrochloride) is an atypical antipsychotic used to treat Bipolar Disorder, Major Depressive Disorder, Schizophrenia.
Pharmacy pays
From ~$4.19/30· 5 forms Save up to 78% in classlurasidone hydrochloride
Boxed warningPrescriptionFDA-sourced
Lurasidone Hydrochloride is an atypical antipsychotic used to treat Bipolar Disorder, Major Depressive Disorder, Schizophrenia.
Pharmacy pays
From ~$4.19/30· 5 forms Save up to 78% in classopipza
Boxed warningPrescriptionFDA-sourced
Opipza (Aripiprazole) is an atypical antipsychotic used to treat Schizophrenia.
Pharmacy pays
From ~$0.10· 8 formspaliperidone
Boxed warningPrescriptionFDA-sourced
Paliperidone is an atypical antipsychotic used to treat Bipolar Disorder, Depressive Disorder, Schizophrenia.
Pharmacy pays
From ~$28.84/30· 4 forms Save up to 94% in classquetiapine fumarate
PrescriptionFDA-sourced
Quetiapine Fumarate is an atypical antipsychotic used to treat Autistic Disorder, Bipolar Disorder, Major Depressive Disorder, Psychotic Disorders.
Pharmacy pays
From ~$0.87/30· 8 forms Save up to 21% in classrexulti
Boxed warningPrescriptionFDA-sourced
Rexulti (Brexpiprazole) is an atypical antipsychotic used to treat Major Depressive Disorder, Schizophrenia.
Price varies
rykindo
Boxed warningPrescriptionFDA-sourced
Rykindo (Risperidone) is an atypical antipsychotic used to treat Autistic Disorder, Bipolar Disorder, Dementia, Tourette Syndrome.
Pharmacy pays
From ~$1.07/30· 8 formssecuado
Boxed warningPrescriptionFDA-sourced
Secuado (Asenapine) is an atypical antipsychotic used to treat Bipolar Disorder, Schizophrenia.
Pharmacy pays
From ~$69.80/30· 3 forms Save up to 97% in classFrequently asked
- What is the best atypical antipsychotic for schizophrenia?
- By our independent recall-safety rating — not an efficacy measure — aristada ranks highest among Atypical Antipsychotic drugs used for schizophrenia. Always consult a professional.
- Which atypical antipsychotic drugs treat schizophrenia?
- pharmaranks lists 29 Atypical Antipsychotic products used for schizophrenia, per NIH RxClass drug-classification data — each independently rated and ranked above.
- How are these ranked?
- By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.