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Best Prostaglandin Analog for glaucoma, open-angle

Top-rated pick: Durysta — pharmaranks score 72/100, the highest of the 6 Prostaglandin Analog drugs used for glaucoma, open-angle, ranked by our independent FDA recall-safety score. Compare them with all treatments for glaucoma, open-angle or the full Prostaglandin Analog class. Not medical advice — always consult a professional.

Quick answer: Of the 6 prostaglandin analog drugs we rate for glaucoma, open-angle, all are available as lower-cost generics, and most are drops. Our ranking reflects each drug’s FDA recall-safety record — not clinical effectiveness for glaucoma, open-angle; the right choice depends on your situation, so confirm it with your prescriber.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

How prostaglandin analog work

Prostaglandin analogs (used as eye drops for glaucoma) activate FP receptors that relax the eye's drainage tissues, helping fluid flow out more easily. This lowers the pressure inside the eye and protects the optic nerve.

Source: Latanoprost - StatPearls - NCBI Bookshelf

Top prostaglandin analog for glaucoma, open-angle: 1. Durysta · 2. Latisse · 3. Lumigan

Best-rated Prostaglandin Analog for glaucoma, open-angle, ranked by pharmaranks score
#DrugRatingPharmacy pays
172/100$8View →
272/100$8View →
370/100$8View →
470/100$85View →
568/100$10View →
6Not yet rated$10View →

Full ranking · 6 drugs

Frequently asked

What is the best prostaglandin analog for glaucoma, open-angle?
By our independent recall-safety rating — not an efficacy measure — durysta ranks highest among Prostaglandin Analog drugs used for glaucoma, open-angle. Always consult a professional.
Which prostaglandin analog drugs treat glaucoma, open-angle?
pharmaranks lists 6 Prostaglandin Analog products used for glaucoma, open-angle, per NIH RxClass drug-classification data — each independently rated and ranked above.
How are these ranked?
By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.