zantac 300

How long does Ranitidine Hydrochloride stay in your body?

The elimination half-life of ranitidine hydrochloride is about 2.5 to 3 hours — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. This is the elimination half-life in adults with normal kidney function, as the label states it. Ranitidine is not a prodrug, and its metabolites (N-oxide, S-oxide, desmethyl-ranitidine — together under ~6% of the dose) are not described by the label as active or longer-lasting than the parent, so there is no active metabolite that outlasts it. The label names two populations where the number changes: in older adults the half-life is 3 to 4 hours, because renal function declines with age; in significant kidney impairment (creatinine clearance 25-35 mL/min) the average plasma half-life was 4.8 hours in four patients, and the label says these parameters shift roughly in proportion to creatinine clearance. In liver impairment (compensated cirrhosis) the label reports only minor, clinically insignificant changes in half-life. Separately, note that ranitidine products were withdrawn from the US market in April 2020 at FDA's request over NDMA contamination; the label above remains the source of the pharmacokinetic figures.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: Ranitidine Tablets USP (Rising Pharma Holdings, Inc.) — DailyMed label, Clinical Pharmacology / Pharmacokinetics.

Frequently asked questions

What does Zantac 300 treat?

Zantac 300 (Ranitidine Hydrochloride) may be used to treat duodenal ulcer, peptic esophagitis, gastroesophageal reflux, stomach ulcer, zollinger-ellison syndrome, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.

How is Zantac 300 rated?

pharmaranks gives Zantac 300 a composite score of 3.5 out of 5, currently based on 1 weighted source (FDA regulatory recall-safety data weighted highest). See our methodology at /how-we-rate.

Is there a coupon or discount for Zantac 300?

pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Zantac 300. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.

Who makes Zantac 300?

Zantac 300 is marketed by Glaxosmithkline. You can see Glaxosmithkline's full profile, rating, and other products on pharmaranks.

Is Zantac 300 a brand-name or generic drug?

Zantac 300 is a brand-name product with the active ingredient Ranitidine Hydrochloride. Lower-cost generic equivalents containing Ranitidine Hydrochloride are available — ask your pharmacist.

Is Zantac 300 available over the counter?

No. Zantac 300 is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.

What forms does Zantac 300 come in?

Zantac 300 is currently marketed as capsule and tablet, per the FDA's National Drug Code Directory.

Is Zantac 300 FDA-registered?

Zantac 300 is on record with the U.S. FDA under application number NDA020095. You can verify this on its official FDA label.

Has Zantac 300 been recalled by the FDA?

Zantac 300 has no FDA recalls recorded under its own application in the openFDA enforcement database. Its recall-safety score reflects its manufacturer's overall recall record. This is general reference, not medical advice — check the FDA recall database for the latest alerts.

Is Zantac 300 safe?

There's no single safe-or-not verdict. pharmaranks gives Zantac 300 a recall-safety score of 70/100, based on its FDA recall history (no recalls under its own FDA application) — not an efficacy or side-effect rating. Review its FDA-label side effects and warnings before use, and always consult a licensed professional.