trazodone hydrochloride

How long does Trazodone Hydrochloride stay in your body?

The elimination half-life of trazodone hydrochloride is about 7 hours (roughly 5 to 9 hours for the slower elimination phase) — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. Trazodone leaves the body in two phases: a faster early phase of about 3 to 6 hours and a slower phase of about 5 to 9 hours, with the parent drug's elimination half-life reported as about 7 hours. The liver (CYP3A4) breaks it into an active metabolite, m-chlorophenylpiperazine (mCPP), which can build up; clearance varies widely between people and is slowed by strong CYP3A4 inhibitors (e.g., ritonavir roughly doubled trazodone's half-life) and in older adults or those with liver impairment. Extended-release forms have a longer half-life (around 9 to 13 hours).

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: FDA Clinical Review, NDA 22-411 (trazodone), Pharmacokinetics — parent-drug elimination half-life ~7.1 h; biphasic 3–6 h / 5–9 h.

Frequently asked questions

What does Trazodone Hydrochloride treat?

Trazodone Hydrochloride (Trazodone Hydrochloride) may be used to treat depressive disorder, sleep initiation and maintenance disorders, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.

How does Trazodone Hydrochloride work?

Trazodone Hydrochloride is a serotonin reuptake inhibitor. Selective serotonin reuptake inhibitors (SSRIs) block the transporter that pulls serotonin back into nerve cells, so more of this mood-related chemical stays in the gaps between neurons to keep signaling. They act mainly on serotonin, which tends to mean fewer side effects than older antidepressants.

How much does Trazodone Hydrochloride cost?

Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $1.52 for 30, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins. Pharmacies pay less for a same-class option, Sertraline Hydrochloride — about $1.09 on the same basis.

Is there a coupon or discount for Trazodone Hydrochloride?

pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Trazodone Hydrochloride. To pay less, Trazodone Hydrochloride is already a generic — usually the lowest-cost version — so the main levers are comparing cash prices between pharmacies and using a pharmacy discount-card service. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.

Who makes Trazodone Hydrochloride?

Trazodone Hydrochloride is marketed by Crossmedika Sa. You can see Crossmedika Sa's full profile, rating, and other products on pharmaranks.

Is Trazodone Hydrochloride a brand-name or generic drug?

Trazodone Hydrochloride is a generic medication; its active ingredient is Trazodone Hydrochloride. Generics contain the same active ingredient as the brand-name original and are usually lower cost.

Is Trazodone Hydrochloride available over the counter?

No. Trazodone Hydrochloride is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.

What forms does Trazodone Hydrochloride come in?

Trazodone Hydrochloride is currently marketed as tablet, per the FDA's National Drug Code Directory.

What class of drug is Trazodone Hydrochloride?

Trazodone Hydrochloride is classified as serotonin reuptake inhibitor, per the FDA's Established Pharmacologic Class.

Is Trazodone Hydrochloride FDA-registered?

Trazodone Hydrochloride is on record with the U.S. FDA under application number ANDA211116. You can verify this on its official FDA label.