SSRIs compared

Compare all 10 SSRIs side by side, used for conditions such as feeding and eating disorders, depressive disorder, obsessive-compulsive disorder. SSRIs are the Serotonin Reuptake Inhibitor class. They share one FDA-defined mechanism but differ in approved uses, prescription status, brand-vs-generic options, price, and FDA recall-safety record — which our independent rating scores. The highest-rated is paroxetine mesylate.

6 of 10 drugs in this class carry a pharmaranks safety score, ranging 66–72 out of 100 — computed from FDA recall records, not from reviews.

Rated against independent sources·Last updated June 7, 2026·How we rate

Top-rated serotonin reuptake inhibitor: 1. Paroxetine Mesylate · 2. Sertraline Hydrochloride · 3. Zoloft

Serotonin Reuptake Inhibitor drugs compared side by side, with pharmaranks' FDA recall-safety rating
Drug	Generic	Form	Status	Used for	Safety ratingFDA recall-based	Pharmacy pays
Paroxetine Mesylate	—	Capsule	Prescription	Feeding and Eating Disorders, Depressive Disorder	72/100	$3
Sertraline Hydrochloride	—	Solution	Prescription	Feeding and Eating Disorders, Depressive Disorder	72/100	$1
Zoloft	Sertraline Hydrochloride	Solution	Prescription	Feeding and Eating Disorders, Depressive Disorder	72/100	$1
Citalopram Hydrobromide	—	Tablet	Prescription	Alcoholism, Dementia	66/100	—
Paxil	Paroxetine Hydrochloride	Tablet	Prescription	Feeding and Eating Disorders, Depressive Disorder	66/100	$3
Paxil CR	Paroxetine Hydrochloride	Tablet	Prescription	Feeding and Eating Disorders, Depressive Disorder	66/100	$3
Brisdelle	Paroxetine Mesylate	Capsule	Prescription	Feeding and Eating Disorders, Depressive Disorder	Not yet rated	$3
Fluoxetine Hydrochloride	—	Capsule	Prescription	Bulimia, Major Depressive Disorder	Not yet rated	$0
Raldesy	Trazodone Hydrochloride	Solution	Prescription	Depressive Disorder, Sleep Initiation and Maintenance Disorders	Not yet rated	$2
Trazodone Hydrochloride	—	Tablet	Prescription	Depressive Disorder, Sleep Initiation and Maintenance Disorders	Not yet rated	$2

The safety rating column is unique to pharmaranks — an independent 0–100 score from FDA regulatory recall data. Higher is safer. Not medical advice.

Best serotonin reuptake inhibitor by condition

for feeding and eating disorders for depressive disorder for obsessive-compulsive disorder for phobic disorders for post-traumatic stress disorders for panic disorder

Full ranking · 10 drugs

Frequently asked questions

What is the Serotonin Reuptake Inhibitor drug class?

Serotonin Reuptake Inhibitor is an FDA Established Pharmacologic Class (EPC) — a group of drugs that share a mechanism of action. pharmaranks lists 10 Serotonin Reuptake Inhibitor products, each independently rated.

Are all Serotonin Reuptake Inhibitor drugs the same?

No. Serotonin Reuptake Inhibitor drugs share the same core mechanism — that is why they sit in one FDA class — but they differ in their approved uses, available forms, whether they are prescription or over-the-counter, brand-vs-generic options and price, and their FDA recall-safety record.

Is "SSRIs" the same as the Serotonin Reuptake Inhibitor class?

Yes — "SSRIs" is the everyday name for the Serotonin Reuptake Inhibitor drug class. This page compares the 10 SSRIs pharmaranks rates, with our independent FDA recall-safety score for each.

What conditions do Serotonin Reuptake Inhibitor drugs treat?

Per NIH RxClass drug-classification data, Serotonin Reuptake Inhibitor drugs are used for conditions including feeding and eating disorders, depressive disorder, obsessive-compulsive disorder, phobic disorders, stress disorders, post-traumatic, panic disorder.

Which Serotonin Reuptake Inhibitor drug is best-rated?

By our independent rating, paroxetine mesylate currently ranks highest among Serotonin Reuptake Inhibitor drugs. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.

Sources: the Serotonin Reuptake Inhibitor class definition and its member drugs come from the U.S. NLM RxClass (Established Pharmacologic Class); how the class works is summarized from Selective Serotonin Reuptake Inhibitors - StatPearls - NCBI Bookshelf. Ratings are pharmaranks’ independent FDA recall-safety analysis.