SERTRALINE HYDROCHLORIDE vs TRAZODONE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. SERTRALINE HYDROCHLORIDE and TRAZODONE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	SERTRALINE HYDROCHLORIDE	TRAZODONE HYDROCHLORIDE
Rating	70/100	New
Pharmacy pays	~$1.09 /30	~$1.52 /30
Type	RX	RX
Active ingredient	SERTRALINE HYDROCHLORIDE	TRAZODONE HYDROCHLORIDE
Manufacturer	Ascent Pharms Inc	Crossmedika Sa
Dosage forms	Solution, Tablet	Tablet
Drug class	Serotonin Reuptake Inhibitor	Serotonin Reuptake Inhibitor
Boxed warning	Boxed warning	None
Half-life	about 26 hours	about 7 hours (roughly 5 to 9 hours for the slower elimination phase)
Treats	Feeding and Eating Disorders, Depressive Disorder, Obsessive-Compulsive Disorder	Depressive Disorder, Sleep Initiation and Maintenance Disorders

sertraline hydrochloride trazodone hydrochloride

Rating

70/100

New

Pharmacy pays

~$1.09 /30

~$1.52 /30

Type

Active ingredient

SERTRALINE HYDROCHLORIDE

TRAZODONE HYDROCHLORIDE

Manufacturer

Ascent Pharms Inc

Crossmedika Sa

Dosage forms

Solution, Tablet

Tablet

Drug class

Serotonin Reuptake Inhibitor

Boxed warning

None

Half-life

about 26 hours

about 7 hours (roughly 5 to 9 hours for the slower elimination phase)

Treats

Feeding and Eating Disorders, Depressive Disorder, Obsessive-Compulsive Disorder

Depressive Disorder, Sleep Initiation and Maintenance Disorders

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Frequently asked questions

Which is cheaper, Sertraline Hydrochloride or Trazodone Hydrochloride?

Sertraline Hydrochloride costs pharmacies less to acquire — about $1.09 vs $1.52 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Sertraline Hydrochloride and Trazodone Hydrochloride?

Sertraline Hydrochloride contains Sertraline Hydrochloride, while Trazodone Hydrochloride contains Trazodone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.