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tenoretic 50

Tenoretic 50 is a combination medicine containing Atenolol and Chlorthalidone.

Atenolol and Chlorthalidone · by Twi Pharms

Available as a generic: Atenolol and Chlorthalidone

Not yet rated· sourced from the FDA label
Rated against independent regulatory sources·Last updated June 7, 2026·How we rate
Verified againstopenFDANIH DailyMedRxClass

Key facts

Active ingredient
Atenolol and Chlorthalidone
Form
Tablet
Strength
Atenolol 50MG; Chlorthalidone 25MG
Type
Prescription (Rx)
Brand or generic
Brand-name
Manufacturer
Twi Pharms
Half-life
about 40 hours on average (the label reports a mean half-life of 40 hours after a 50–200 mg dose, and an elimination half-life of 53 hours after 50 mg and 60 hours after 100 mg) (how long it stays in your system)
What the pharmacy pays
~$0.76 for 30 — not your price
FDA application
NDA018760
Availability
Discontinued (per FDA)

How long does Atenolol and Chlorthalidone stay in your body?

The elimination half-life of atenolol and chlorthalidone is about 40 hours on average (the label reports a mean half-life of 40 hours after a 50–200 mg dose, and an elimination half-life of 53 hours after 50 mg and 60 hours after 100 mg) — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. This is an older-format label (CLINICAL PHARMACOLOGY, not a PLR §12.3), and it gives its numbers in two ways: a mean half-life of 40 hours across the 50–200 mg dose range, and dose-specific elimination half-lives of 53 hours (50 mg) and 60 hours (100 mg). Only one phase is described, so the figures above are the elimination values the label states — it does not report a separate distribution phase. No active metabolite is described: the label says chlorthalidone is largely excreted unchanged by the kidneys and that data on metabolites and non-renal elimination routes "have yet to be clarified." It is not a prodrug. Do not confuse the half-life with the duration of diuretic effect — the label describes diuresis beginning in about 2.6 hours and continuing up to 72 hours, which is a different measure. The label does NOT quantify how the half-life changes with age, kidney impairment, or liver impairment; it gives no geriatric or renal/hepatic pharmacokinetic numbers. It does warn that cumulative effects of the drug may develop in patients with impaired renal function, and to use caution in severe renal disease and in impaired hepatic function — but it does not state a half-life for those groups, so no number should be inferred for them.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: DailyMed — CHLORTHALIDONE tablet (Clinical Pharmacology).

Dosage forms

Tablet

The forms currently marketed in the U.S., per the FDA National Drug Code Directory.

Ways to save

Ask for the generic

Same active ingredient, far cheaper. Is there a generic? →

Request a 90-day supply

Bulk fills usually lower the per-dose price vs monthly refills.

Use copay cards

Manufacturer copay cards & patient-assistance programs — especially for brand drugs.

Compare alternatives

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Frequently asked questions

How much does Tenoretic 50 cost?
Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $0.76 for 30, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.
Is there a coupon or discount for Tenoretic 50?
pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Tenoretic 50. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
Who makes Tenoretic 50?
Tenoretic 50 is marketed by Twi Pharms. You can see Twi Pharms's full profile, rating, and other products on pharmaranks.
Is Tenoretic 50 a brand-name or generic drug?
Tenoretic 50 is a brand-name product with the active ingredient Atenolol and Chlorthalidone. Lower-cost generic equivalents containing Atenolol and Chlorthalidone are available — ask your pharmacist.
Is Tenoretic 50 available over the counter?
No. Tenoretic 50 is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
What forms does Tenoretic 50 come in?
Tenoretic 50 is currently marketed as tablet, per the FDA's National Drug Code Directory.
Is Tenoretic 50 FDA-registered?
Tenoretic 50 is on record with the U.S. FDA under application number NDA018760. You can verify this on its official FDA label.

Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.

What people report to the FDA about ATENOLOL AND CHLORTHALIDONE

The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 760 reports naming ATENOLOL AND CHLORTHALIDONE — the active ingredient in Tenoretic 50, and the FDA flagged 70% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:

  • nausea102 reports
  • rash79 reports
  • headache78 reports
  • hypertension78 reports
  • drug intolerance74 reports
  • arthralgia73 reports
  • diarrhoea73 reports
  • dyspnoea73 reports

Read these as a signal, not a rate. A report does not mean ATENOLOL AND CHLORTHALIDONE caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label.

Source: openFDA drug/event (FAERS), retrieved September 25, 2026.

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