MYSOLINE vs TENORETIC 50

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 7, 2026·How we rate

Possible drug interaction. MYSOLINE and TENORETIC 50 are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	MYSOLINE	TENORETIC 50
Rating	74/100	New
Pharmacy pays	~$2.89 /30	~$0.76 /30
Type	RX	RX
Active ingredient	PRIMIDONE	ATENOLOL AND CHLORTHALIDONE
Manufacturer	Valeant Pharm Intl	Twi Pharms
Dosage forms	Tablet	Tablet
Drug class	Anti-Epileptic Agent	—
Boxed warning	None	None
Half-life	—	about 40 hours on average (the label reports a mean half-life of 40 hours after a 50–200 mg dose, and an elimination half-life of 53 hours after 50 mg and 60 hours after 100 mg)
Treats	Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor	—

mysoline tenoretic 50

Rating

74/100

New

Pharmacy pays

~$2.89 /30

~$0.76 /30

Type

Active ingredient

PRIMIDONE

ATENOLOL AND CHLORTHALIDONE

Manufacturer

Valeant Pharm Intl

Twi Pharms

Dosage forms

Tablet

Drug class

Anti-Epileptic Agent

—

Boxed warning

None

Half-life

—

about 40 hours on average (the label reports a mean half-life of 40 hours after a 50–200 mg dose, and an elimination half-life of 53 hours after 50 mg and 60 hours after 100 mg)

Treats

Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

—

Frequently asked questions

Which is cheaper, Mysoline or Tenoretic 50?

Tenoretic 50 costs pharmacies less to acquire — about $0.76 vs $2.89 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Mysoline and Tenoretic 50?

Mysoline contains Primidone, while Tenoretic 50 contains Atenolol and Chlorthalidone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.