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sildenafil citrate

Sildenafil Citrate is a phosphodiesterase 5 inhibitor used to treat Pulmonary Hypertension, Vasculogenic Impotence.

Phosphodiesterase 5 Inhibitor · by Actavis Grp Ptc

Generic of Vybrique

Not yet rated· sourced from the FDA label
Rated against independent regulatory sources·Last updated June 7, 2026·How we rate
Verified againstopenFDANIH DailyMedRxClass
$0.11 /mL
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Key facts

Active ingredient
Sildenafil Citrate
Form
Tablet
Strength
Sildenafil Citrate EQ 20MG Base
Type
Prescription (Rx)
Brand or generic
Generic
Manufacturer
Actavis Grp Ptc
Half-life
about 4 hours (how long it stays in your system)
What the pharmacy pays
~$0.11 per ml — not your price
FDA application
ANDA200149
Availability
Discontinued (per FDA)

How long does Sildenafil Citrate stay in your body?

The elimination half-life of sildenafil citrate is about 4 hours — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. Sildenafil's active N-desmethyl metabolite also has a terminal half-life of about 4 hours, so it is not materially longer. In older adults and in people with significant kidney or liver impairment, the label reports reduced drug clearance and higher blood levels (AUC/Cmax) of sildenafil — the label does not state the half-life itself is longer.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: Viagra- sildenafil citrate tablet, film coated (DailyMed).

Drug class

How this class works, per PDE5 Inhibitors - StatPearls - NCBI Bookshelf.

May treat (source: NIH RxClass)

See how Sildenafil Citrate ranks — best-rated phosphodiesterase 5 inhibitor for:

Dosage forms

Tablet

The forms currently marketed in the U.S., per the FDA National Drug Code Directory.

Ways to save

Ask for the generic

Same active ingredient, far cheaper. Is there a generic? →

Request a 90-day supply

Bulk fills usually lower the per-dose price vs monthly refills.

Use copay cards

Manufacturer copay cards & patient-assistance programs — especially for brand drugs.

Compare alternatives

A same-class option may cost less. See alternatives →

Frequently asked questions

What does Sildenafil Citrate treat?
Sildenafil Citrate (Sildenafil Citrate) may be used to treat pulmonary hypertension, vasculogenic impotence, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
How does Sildenafil Citrate work?
Sildenafil Citrate is a phosphodiesterase 5 inhibitor. PDE5 inhibitors block the enzyme that breaks down cGMP, a signal that relaxes blood vessels. Letting cGMP build up widens vessels and boosts blood flow, which helps erectile dysfunction and eases pressure in the lung arteries.
How much does Sildenafil Citrate cost?
Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $0.11 per ml, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.
Is there a coupon or discount for Sildenafil Citrate?
pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Sildenafil Citrate. To pay less, Sildenafil Citrate is already a generic — usually the lowest-cost version — so the main levers are comparing cash prices between pharmacies and using a pharmacy discount-card service. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
Who makes Sildenafil Citrate?
Sildenafil Citrate is marketed by Actavis Grp Ptc. You can see Actavis Grp Ptc's full profile, rating, and other products on pharmaranks.
Is Sildenafil Citrate a brand-name or generic drug?
Sildenafil Citrate is a generic medication; its active ingredient is Sildenafil Citrate. Generics contain the same active ingredient as the brand-name original and are usually lower cost.
Is Sildenafil Citrate available over the counter?
No. Sildenafil Citrate is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
What forms does Sildenafil Citrate come in?
Sildenafil Citrate is currently marketed as tablet, per the FDA's National Drug Code Directory.
What class of drug is Sildenafil Citrate?
Sildenafil Citrate is classified as phosphodiesterase 5 inhibitor, per the FDA's Established Pharmacologic Class.
Is Sildenafil Citrate FDA-registered?
Sildenafil Citrate is on record with the U.S. FDA under application number ANDA200149. You can verify this on its official FDA label.

Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.

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