ED pills compared
Compare all 7 ED pills side by side, used for conditions such as hypertension, pulmonary, impotence, vasculogenic. ED pills are the Phosphodiesterase 5 Inhibitor class. They share one FDA-defined mechanism but differ in approved uses, prescription status, brand-vs-generic options, price, and FDA recall-safety record — which our independent rating scores. The highest-rated is vybrique.
Top-rated phosphodiesterase 5 inhibitor: 1. Vybrique · 2. Adcirca · 3. Revatio
| Drug | Generic | Form | Status | Used for | Safety ratingFDA recall-based | Pharmacy pays |
|---|---|---|---|---|---|---|
| Vybrique | Sildenafil Citrate | Film | Prescription | Hypertension, Pulmonary, Impotence, Vasculogenic | 72/100 | $0 |
| Adcirca | Tadalafil | Tablet | Prescription | Hypertension, Pulmonary, Impotence, Vasculogenic | 70/100 | $4 |
| Revatio | Sildenafil Citrate | Injectable | Prescription | Hypertension, Pulmonary, Impotence, Vasculogenic | 70/100 | $0 |
| Viagra | Sildenafil Citrate | Tablet | Prescription | Hypertension, Pulmonary, Impotence, Vasculogenic | 70/100 | $0 |
| Alyq | Tadalafil | Tablet | Prescription | Hypertension, Pulmonary, Impotence, Vasculogenic | 56/100 | $4 |
| Cialis | Tadalafil | Tablet | Prescription | Hypertension, Pulmonary, Impotence, Vasculogenic | Not yet rated | $4 |
| Tadliq | Tadalafil | Suspension | Prescription | Hypertension, Pulmonary, Impotence, Vasculogenic | Not yet rated | $4 |
The safety rating column is unique to pharmaranks — an independent 0–100 score from FDA regulatory recall data. Higher is safer. Not medical advice.
Best phosphodiesterase 5 inhibitor by condition
Full ranking · 7 drugs
- 172/100
vybrique
Sildenafil Citrate
- 270/100
adcirca
Tadalafil
- 370/100
revatio
Sildenafil Citrate
- 470/100
viagra
Sildenafil Citrate
- 556/100
alyq
Tadalafil
- 6New
cialis
Tadalafil
- 7New
tadliq
Tadalafil
Frequently asked questions
What is the Phosphodiesterase 5 Inhibitor drug class?
Phosphodiesterase 5 Inhibitor is an FDA Established Pharmacologic Class (EPC) — a group of drugs that share a mechanism of action. pharmaranks lists 7 Phosphodiesterase 5 Inhibitor products, each independently rated.
Are all Phosphodiesterase 5 Inhibitor drugs the same?
No. Phosphodiesterase 5 Inhibitor drugs share the same core mechanism — that is why they sit in one FDA class — but they differ in their approved uses, available forms, whether they are prescription or over-the-counter, brand-vs-generic options and price, and their FDA recall-safety record.
Is "ED pills" the same as the Phosphodiesterase 5 Inhibitor class?
Yes — "ED pills" is the everyday name for the Phosphodiesterase 5 Inhibitor drug class. This page compares the 7 ED pills pharmaranks rates, with our independent FDA recall-safety score for each.
What conditions do Phosphodiesterase 5 Inhibitor drugs treat?
Per NIH RxClass drug-classification data, Phosphodiesterase 5 Inhibitor drugs are used for conditions including hypertension, pulmonary, impotence, vasculogenic.
Which Phosphodiesterase 5 Inhibitor drug is best-rated?
By our independent rating, vybrique currently ranks highest among Phosphodiesterase 5 Inhibitor drugs. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.
Sources: the Phosphodiesterase 5 Inhibitor class definition and its member drugs come from the U.S. NLM RxClass (Established Pharmacologic Class); how the class works is summarized from PDE5 Inhibitors - StatPearls - NCBI Bookshelf. Ratings are pharmaranks’ independent FDA recall-safety analysis.