phospholine iodide
Phospholine Iodide (Echothiophate Iodide) is a medication used to treat Esotropia, Glaucoma, Open-Angle Glaucoma, Angle-Closure Glaucoma.
Echothiophate Iodide · by Fera Pharms LLC
⚠ FDA reports a current shortage of the ophthalmic solution form (available) — see drug shortages →Key facts
- Active ingredient
- Echothiophate Iodide
- Form
- Kit
- Strength
- Echothiophate Iodide 0.03% · Echothiophate Iodide 0.06% · Echothiophate Iodide 0.125% · Echothiophate Iodide 0.25%
- Type
- Prescription (Rx)
- Brand or generic
- Brand-name
- May treat
- esotropia, glaucoma, open-angle glaucoma
- Manufacturer
- Fera Pharms LLC
- FDA application
- NDA011963
What is Phospholine Iodide?
From the FDA label:Chemical name: (2-mercaptoethyl) trimethylammonium iodide O,O-diethyl phosphorothioate Structural formula Echothiophate iodide for ophthalmic solution occurs as a white, crystalline, water-soluble, hygroscopic solid having a slight mercaptan-like odor. When freeze-dried in the presence of potassium acetate, the mixture appears as a white amorphous deposit on the walls of the bottle. Each package contains materials for dispensing 5 mL of eyedrops: (1) bottle containing sterile echothiophate iodide for ophthalmic solution 6.25 mg (0.125%) with 40 mg potassium acetate. Sodium hydroxide or acetic acid may have been incorporated to adjust pH during manufacturing; (2) a 5 mL bottle of sterile diluent containing chlorobutanol (chloral derivative), 0.55%; mannitol, 1.2%; boric acid, 0.06%; and sodium phosphate, 0.026%; (3) sterilized dropper. Structural Formula
Side effects
Although the relationship, if any, of retinal detachment to the administration of echothiophate iodide for ophthalmic solution has not been established, retinal detachment has been reported in a few cases during the use of echothiophate iodide for ophthalmic solution in adult patients without a previous history of this disorder. Stinging, burning, lacrimation, lid muscle twitching, conjunctival and ciliary redness, browache, induced myopia with visual blurring may occur. Activation of latent iritis or uveitis may occur. Iris cysts may form, and if treatment is continued, may enlarge and obscure vision. This occurrence is more frequent in children. The cysts usually shrink upon discontinuance of the medication or by reducing the frequency of instillation. Rarely, they may rupture or break free into the aqueous. Regular examinations are advisable when the drug is being prescribed for the treatment of accommodative esotropia. Prolonged use may cause conjunctival thickening, obstruction of nasolacrimal canals. Lens opacities have been reported with echothiophate iodide. Paradoxical increase in IOP may follow anticholinesterase instillation. This may be alleviated by prescribing a sympathomimetic mydriatic such as phenylephrine. Cardiac irregularities.
Warnings
Important safety information
Succinylcholine should be administered only with great caution, if at all, prior to or during general anesthesia to patients receiving anticholinesterase medication because of possible respiratory or cardiovascular collapse. Caution should be observed in treating elevated IOP with echothiophate iodide for ophthalmic solution in patients who are at the same time undergoing treatment with systemic anticholinesterase medications, because of possible adverse additive effects.
Who should not take Phospholine Iodide
Active uveal inflammation. Most cases of angle-closure glaucoma without iridectomy, due to the possibility of increasing angle block. Hypersensitivity to the active or inactive ingredients.
Interactions
Echothiophate iodide for ophthalmic solution potentiates other cholinesterase inhibitors such as succinylcholine or organophosphate and carbamate insecticides. Patients undergoing systemic anticholinesterase treatment should be warned of the possible additive effects of echothiophate iodide for ophthalmic solution.
May treat (source: NIH RxClass)
Dosage forms
Kit
The forms currently marketed in the U.S., per the FDA National Drug Code Directory.
Ways to save
Ask for the generic
Same active ingredient, far cheaper. Is there a generic? →
Request a 90-day supply
Bulk fills usually lower the per-dose price vs monthly refills.
Use copay cards
Manufacturer copay cards & patient-assistance programs — especially for brand drugs.
Compare alternatives
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Frequently asked questions
- What does Phospholine Iodide treat?
- Phospholine Iodide (Echothiophate Iodide) may be used to treat esotropia, glaucoma, open-angle glaucoma, angle-closure glaucoma, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
- Is there a coupon or discount for Phospholine Iodide?
- pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Phospholine Iodide. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
- Who makes Phospholine Iodide?
- Phospholine Iodide is marketed by Fera Pharms LLC. You can see Fera Pharms LLC's full profile, rating, and other products on pharmaranks.
- Is Phospholine Iodide a brand-name or generic drug?
- Phospholine Iodide is a brand-name product with the active ingredient Echothiophate Iodide.
- Is Phospholine Iodide available over the counter?
- No. Phospholine Iodide is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
- What forms does Phospholine Iodide come in?
- Phospholine Iodide is currently marketed as kit, per the FDA's National Drug Code Directory.
- Is Phospholine Iodide FDA-registered?
- Phospholine Iodide is on record with the U.S. FDA under application number NDA011963. You can verify this on its official FDA label.
- Is Phospholine Iodide safe?
- There's no single safe-or-not verdict, and we don't yet have a composite recall-safety score for Phospholine Iodide. Review its FDA-label side effects and warnings below, and always consult a licensed professional.
- What are the side effects of Phospholine Iodide?
- Phospholine Iodide's side effects are taken directly from its FDA label. From the label: Although the relationship, if any, of retinal detachment to the administration of echothiophate iodide for ophthalmic solution has not been established,… Both common and serious reactions are documented in full on this page. This is general reference from the FDA, not medical advice — always consult a professional.
Clinical content sourced from the FDA label via openFDA (U.S. FDA). View the FDA label on DailyMed → Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.
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