loperamide hydrochloride and simethicone

How long does Loperamide Hydrochloride and Simethicone stay in your body?

The elimination half-life of loperamide hydrochloride and simethicone is about 10.8 hours (range 9.1 to 14.4 hours) — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. Per the FDA label, the apparent elimination half-life of loperamide is 10.8 hours (range 9.1–14.4 hours), so most of a dose clears in roughly 2–3 days. Loperamide is metabolized in the liver (mainly CYP2C8 and CYP3A4) via N-demethylation; the label does not characterize the N-demethyl metabolite's half-life, so no metabolite-specific clearance number is given. People with liver impairment clear it more slowly (reduced first-pass metabolism — use with caution); the label reports no pharmacokinetic data in kidney impairment, and no major disposition differences in elderly patients.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: IMODIUM (loperamide hydrochloride) capsule — DailyMed FDA label.

Frequently asked questions

How is Loperamide Hydrochloride and Simethicone rated?

pharmaranks gives Loperamide Hydrochloride and Simethicone a composite score of 3.2 out of 5, currently based on 1 weighted source (FDA regulatory recall-safety data weighted highest). See our methodology at /how-we-rate.

How much does Loperamide Hydrochloride and Simethicone cost?

Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $0.05 per ml, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.

Is there a coupon or discount for Loperamide Hydrochloride and Simethicone?

pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Loperamide Hydrochloride and Simethicone. To pay less, Loperamide Hydrochloride and Simethicone is already a generic — usually the lowest-cost version — so the main levers are comparing cash prices between pharmacies and using a pharmacy discount-card service. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.

Who makes Loperamide Hydrochloride and Simethicone?

Loperamide Hydrochloride and Simethicone is marketed by Perrigo. You can see Perrigo's full profile, rating, and other products on pharmaranks.

Is Loperamide Hydrochloride and Simethicone a brand-name or generic drug?

Loperamide Hydrochloride and Simethicone is a generic medication; its active ingredient is Loperamide Hydrochloride and Simethicone. Generics contain the same active ingredient as the brand-name original and are usually lower cost.

Is Loperamide Hydrochloride and Simethicone available over the counter?

No. Loperamide Hydrochloride and Simethicone is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.

What forms does Loperamide Hydrochloride and Simethicone come in?

Loperamide Hydrochloride and Simethicone is currently marketed as tablet, per the FDA's National Drug Code Directory.

Is Loperamide Hydrochloride and Simethicone FDA-registered?

Loperamide Hydrochloride and Simethicone is on record with the U.S. FDA under application number ANDA076029. You can verify this on its official FDA label.

Has Loperamide Hydrochloride and Simethicone been recalled by the FDA?

Loperamide Hydrochloride and Simethicone has no FDA recalls recorded under its own application in the openFDA enforcement database. Its recall-safety score reflects its manufacturer's overall recall record. This is general reference, not medical advice — check the FDA recall database for the latest alerts.

Is Loperamide Hydrochloride and Simethicone safe?

There's no single safe-or-not verdict. pharmaranks gives Loperamide Hydrochloride and Simethicone a recall-safety score of 64/100, based on its FDA recall history (no recalls under its own FDA application) — not an efficacy or side-effect rating. Review its FDA-label side effects and warnings before use, and always consult a licensed professional.