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IMODIUM MULTI-SYMPTOM RELIEF vs LOPERAMIDE HYDROCHLORIDE AND SIMETHICONE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Rating

70/100
64/100

Pharmacy pays

$0.05 /mL
$0.05 /mL

Type

OTC
RX

Active ingredient

LOPERAMIDE HYDROCHLORIDE AND SIMETHICONE
LOPERAMIDE HYDROCHLORIDE AND SIMETHICONE

Dosage forms

Tablet
Tablet

Drug class

Boxed warning

None
None

Half-life

about 10.8 hours (range 9.1 to 14.4 hours)
about 10.8 hours (range 9.1 to 14.4 hours)

Get imodium multi-symptom reliefhigher-rated option

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Where to buy

Buy over-the-counter from trusted retailers.

Frequently asked questions

Which is better-rated, Imodium Multi-Symptom Relief or Loperamide Hydrochloride and Simethicone?

By our independent rating, Imodium Multi-Symptom Relief scores higher — 3.5 vs 3.2 out of 5 for Loperamide Hydrochloride and Simethicone. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Imodium Multi-Symptom Relief or Loperamide Hydrochloride and Simethicone?

Pharmacies pay about the same to acquire either one — roughly $0.05 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Imodium Multi-Symptom Relief and Loperamide Hydrochloride and Simethicone?

Both Imodium Multi-Symptom Relief and Loperamide Hydrochloride and Simethicone share the active ingredient Loperamide Hydrochloride and Simethicone, but Imodium Multi-Symptom Relief is sold as OTC and Loperamide Hydrochloride and Simethicone as RX.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.