levomilnacipran hydrochloride

How long does Levomilnacipran Hydrochloride stay in your body?

The elimination half-life of levomilnacipran hydrochloride is about 12 hours — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. This is the apparent terminal elimination half-life of the parent drug; the label reports no separate distribution/terminal split. Levomilnacipran (the active enantiomer of milnacipran, marketed as Fetzima extended-release) is metabolized to desethyl levomilnacipran and p-hydroxy levomilnacipran, but the label states these metabolites are INACTIVE, so no active metabolite outlasts the parent. Populations: the label recommends NO dose adjustment based on age (older adults) and NO dose adjustment for mild, moderate, or severe HEPATIC impairment, implying no clinically meaningful change in half-life there. RENAL function is the key factor — renal excretion predominates (about 58% excreted unchanged in urine), so exposure rises with declining kidney function: the maximum dose is capped at 80 mg/day in moderate and 40 mg/day in severe renal impairment, and the drug is not recommended in end-stage renal disease. The label does not give explicit per-population half-life numbers.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: Fetzima (levomilnacipran) FDA label — DailyMed, §12.3 Pharmacokinetics.

Frequently asked questions

What does Levomilnacipran Hydrochloride treat?

Levomilnacipran Hydrochloride (Levomilnacipran Hydrochloride) may be used to treat major depressive disorder, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.

How does Levomilnacipran Hydrochloride work?

Levomilnacipran Hydrochloride is a serotonin and norepinephrine reuptake inhibitor. SNRIs slow the reabsorption of two brain chemicals, serotonin and norepinephrine, back into nerve cells. This leaves more of both available in the gaps between neurons to keep signaling, which can improve mood, anxiety, and certain types of chronic pain.

How is Levomilnacipran Hydrochloride rated?

pharmaranks gives Levomilnacipran Hydrochloride a composite score of 3.6 out of 5, currently based on 1 weighted source (FDA regulatory recall-safety data weighted highest). See our methodology at /how-we-rate.

Is there a coupon or discount for Levomilnacipran Hydrochloride?

pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Levomilnacipran Hydrochloride. To pay less, Levomilnacipran Hydrochloride is already a generic — usually the lowest-cost version — so the main levers are comparing cash prices between pharmacies and using a pharmacy discount-card service. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.

Who makes Levomilnacipran Hydrochloride?

Levomilnacipran Hydrochloride is marketed by Prinston Inc. You can see Prinston Inc's full profile, rating, and other products on pharmaranks.

Is Levomilnacipran Hydrochloride a brand-name or generic drug?

Levomilnacipran Hydrochloride is a generic medication; its active ingredient is Levomilnacipran Hydrochloride. Generics contain the same active ingredient as the brand-name original and are usually lower cost.

Is Levomilnacipran Hydrochloride available over the counter?

No. Levomilnacipran Hydrochloride is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.

What forms does Levomilnacipran Hydrochloride come in?

Levomilnacipran Hydrochloride is currently marketed as capsule, extended release, per the FDA's National Drug Code Directory.

What class of drug is Levomilnacipran Hydrochloride?

Levomilnacipran Hydrochloride is classified as serotonin and norepinephrine reuptake inhibitor, per the FDA's Established Pharmacologic Class.

Is Levomilnacipran Hydrochloride FDA-registered?

Levomilnacipran Hydrochloride is on record with the U.S. FDA under application number ANDA210771. You can verify this on its official FDA label.

Has Levomilnacipran Hydrochloride been recalled by the FDA?

Levomilnacipran Hydrochloride has no FDA recalls recorded under its own application in the openFDA enforcement database. Its recall-safety score reflects its manufacturer's overall recall record. This is general reference, not medical advice — check the FDA recall database for the latest alerts.

Is Levomilnacipran Hydrochloride safe?

There's no single safe-or-not verdict. pharmaranks gives Levomilnacipran Hydrochloride a recall-safety score of 72/100, based on its FDA recall history (no recalls under its own FDA application) — not an efficacy or side-effect rating. Review its FDA-label side effects and warnings before use, and always consult a licensed professional.