SNRIs compared
Compare all 10 SNRIs side by side, used for conditions such as major depressive disorder, anxiety disorders, diabetic neuropathies. SNRIs are the Serotonin and Norepinephrine Reuptake Inhibitor class. They share one FDA-defined mechanism but differ in approved uses, prescription status, brand-vs-generic options, price, and FDA recall-safety record — which our independent rating scores. The highest-rated is fetzima.
Top-rated serotonin and norepinephrine reuptake inhibitor: 1. Fetzima · 2. Levomilnacipran Hydrochloride · 3. Savella
| Drug | Generic | Form | Status | Used for | Safety ratingFDA recall-based | Pharmacy pays |
|---|---|---|---|---|---|---|
| Fetzima | Levomilnacipran Hydrochloride | Capsule | Prescription | Major Depressive Disorder | 72/100 | — |
| Levomilnacipran Hydrochloride | — | Capsule | Prescription | Major Depressive Disorder | 72/100 | — |
| Savella | Milnacipran Hydrochloride | Kit | Prescription | Major Depressive Disorder | 72/100 | $97 |
| Desvenlafaxine Succinate | — | Tablet | Prescription | Major Depressive Disorder | 70/100 | $115 |
| Cymbalta | Duloxetine Hydrochloride | Capsule | Prescription | Anxiety Disorders, Major Depressive Disorder | Not yet rated | $3 |
| Drizalma Sprinkle | Duloxetine Hydrochloride | Capsule | Prescription | Anxiety Disorders, Major Depressive Disorder | Not yet rated | $3 |
| Effexor XR | Venlafaxine Hydrochloride | Capsule | Prescription | Attention Deficit Disorder with Hyperactivity, Autistic Disorder | Not yet rated | $4 |
| Milnacipran Hydrochloride | — | Tablet | Prescription | Major Depressive Disorder | Not yet rated | $97 |
| Pristiq | Desvenlafaxine Succinate | Tablet | Prescription | Major Depressive Disorder | Not yet rated | $115 |
| Venlafaxine Hydrochloride | — | Capsule | Prescription | Attention Deficit Disorder with Hyperactivity, Autistic Disorder | Not yet rated | $4 |
The safety rating column is unique to pharmaranks — an independent 0–100 score from FDA regulatory recall data. Higher is safer. Not medical advice.
Best serotonin and norepinephrine reuptake inhibitor by condition
Full ranking · 10 drugs
- 172/100
fetzima
Levomilnacipran Hydrochloride
- 272/100
levomilnacipran hydrochloride
Levomilnacipran Hydrochloride
- 372/100
savella
Milnacipran Hydrochloride
- 470/100
desvenlafaxine succinate
Desvenlafaxine Succinate
- 5New
cymbalta
Duloxetine Hydrochloride
- 6New
drizalma sprinkle
Duloxetine Hydrochloride
- 7New
effexor xr
Venlafaxine Hydrochloride
- 8New
milnacipran hydrochloride
Milnacipran Hydrochloride
- 9New
pristiq
Desvenlafaxine Succinate
- 10New
venlafaxine hydrochloride
Venlafaxine Hydrochloride
Frequently asked questions
What is the Serotonin and Norepinephrine Reuptake Inhibitor drug class?
Serotonin and Norepinephrine Reuptake Inhibitor is an FDA Established Pharmacologic Class (EPC) — a group of drugs that share a mechanism of action. pharmaranks lists 10 Serotonin and Norepinephrine Reuptake Inhibitor products, each independently rated.
Are all Serotonin and Norepinephrine Reuptake Inhibitor drugs the same?
No. Serotonin and Norepinephrine Reuptake Inhibitor drugs share the same core mechanism — that is why they sit in one FDA class — but they differ in their approved uses, available forms, whether they are prescription or over-the-counter, brand-vs-generic options and price, and their FDA recall-safety record.
Is "SNRIs" the same as the Serotonin and Norepinephrine Reuptake Inhibitor class?
Yes — "SNRIs" is the everyday name for the Serotonin and Norepinephrine Reuptake Inhibitor drug class. This page compares the 10 SNRIs pharmaranks rates, with our independent FDA recall-safety score for each.
What conditions do Serotonin and Norepinephrine Reuptake Inhibitor drugs treat?
Per NIH RxClass drug-classification data, Serotonin and Norepinephrine Reuptake Inhibitor drugs are used for conditions including major depressive disorder, anxiety disorders, diabetic neuropathies, musculoskeletal pain, attention deficit disorder with hyperactivity, autistic disorder.
Which Serotonin and Norepinephrine Reuptake Inhibitor drug is best-rated?
By our independent rating, fetzima currently ranks highest among Serotonin and Norepinephrine Reuptake Inhibitor drugs. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.
Sources: the Serotonin and Norepinephrine Reuptake Inhibitor class definition and its member drugs come from the U.S. NLM RxClass (Established Pharmacologic Class); how the class works is summarized from Duloxetine - StatPearls - NCBI Bookshelf. Ratings are pharmaranks’ independent FDA recall-safety analysis.