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Ismo (Isosorbide Mononitrate) is a nitrate vasodilator used to treat Angina Pectoris, Coronary Disease, Cyanosis, Gastroesophageal Reflux.

Isosorbide Mononitrate · by Promius Pharma

Available as a generic: Isosorbide Mononitrate

Not yet rated· sourced from the FDA label
Rated against independent regulatory sources·Last updated June 7, 2026·How we rate
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Key facts

Active ingredient
Isosorbide Mononitrate
Form
Tablet
Strength
Isosorbide Mononitrate 20MG
Type
Prescription (Rx)
Brand or generic
Brand-name
Manufacturer
Promius Pharma
FDA application
NDA019091
Availability
Discontinued (per FDA)

Drug class

How this class works, per Nitrates - StatPearls - NCBI Bookshelf.

May treat (source: NIH RxClass)

See how Ismo ranks — best-rated nitrate vasodilator for:

Dosage forms

Tablet

The forms currently marketed in the U.S., per the FDA National Drug Code Directory.

Ways to save

Ask for the generic

Same active ingredient, far cheaper. Is there a generic? →

Request a 90-day supply

Bulk fills usually lower the per-dose price vs monthly refills.

Use copay cards

Manufacturer copay cards & patient-assistance programs — especially for brand drugs.

Compare alternatives

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Frequently asked questions

What does Ismo treat?
Ismo (Isosorbide Mononitrate) may be used to treat angina pectoris, coronary disease, cyanosis, gastroesophageal reflux, heart failure, poisoning, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
How does Ismo work?
Ismo is a nitrate vasodilator. Nitrate vasodilators are converted in the body into nitric oxide, which relaxes the smooth muscle in blood vessel walls and widens them. This mainly opens up the veins, reducing how hard the heart must work and relieving chest pain.
Is there a coupon or discount for Ismo?
pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Ismo. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
Who makes Ismo?
Ismo is marketed by Promius Pharma. You can see Promius Pharma's full profile, rating, and other products on pharmaranks.
Is Ismo a brand-name or generic drug?
Ismo is a brand-name product with the active ingredient Isosorbide Mononitrate. Lower-cost generic equivalents containing Isosorbide Mononitrate are available — ask your pharmacist.
Is Ismo available over the counter?
No. Ismo is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
What forms does Ismo come in?
Ismo is currently marketed as tablet, per the FDA's National Drug Code Directory.
What class of drug is Ismo?
Ismo is classified as nitrate vasodilator, per the FDA's Established Pharmacologic Class.
Is Ismo FDA-registered?
Ismo is on record with the U.S. FDA under application number NDA019091. You can verify this on its official FDA label.

Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.

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