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entereg

Pharmaranks rates Entereg 3.6/5 for recall safety — an independent score from its FDA recall history and its manufacturer's record. Entereg (Alvimopan) is an opioid antagonist.

Alvimopan · by Cubist Pharms LLC

72/100Limited · 1 source

Based on 1 source · Recall-safety score from FDA recall history — this product's own recalls and its manufacturer's record. Not an efficacy or quality rating. methodology →

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate
Verified againstopenFDANIH DailyMedRxClass

Key facts

Active ingredient
Alvimopan
Form
Capsule
Strength
Alvimopan 12MG **Federal Register Determination That Product was not Discontinued or Withdrawn for Safety or Effectiveness reasons**
Type
Prescription (Rx)
Brand or generic
Brand-name
Manufacturer
Cubist Pharms LLC
FDA application
NDA021775
Availability
Discontinued (per FDA)

Drug class

How this class works, per Opioid Antagonists - StatPearls - NCBI Bookshelf.

Dosage forms

Capsule

The forms currently marketed in the U.S., per the FDA National Drug Code Directory.

Ways to save

Ask for the generic

Same active ingredient, far cheaper. Is there a generic? →

Request a 90-day supply

Bulk fills usually lower the per-dose price vs monthly refills.

Use copay cards

Manufacturer copay cards & patient-assistance programs — especially for brand drugs.

Compare alternatives

A same-class option may cost less. See alternatives →

Frequently asked questions

How does Entereg work?
Entereg is a opioid antagonist. Opioid antagonists attach to the same brain and body receptors that opioids use, but without switching them on. By occupying those receptors, they block opioids from binding and can rapidly reverse an overdose or curb opioid cravings.
How is Entereg rated?
pharmaranks gives Entereg a composite score of 3.6 out of 5, currently based on 1 weighted source (FDA regulatory recall-safety data weighted highest). See our methodology at /how-we-rate.
Is there a coupon or discount for Entereg?
pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Entereg. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
Who makes Entereg?
Entereg is marketed by Cubist Pharms LLC. You can see Cubist Pharms LLC's full profile, rating, and other products on pharmaranks.
Is Entereg a brand-name or generic drug?
Entereg is a brand-name product with the active ingredient Alvimopan.
Is Entereg available over the counter?
No. Entereg is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
What forms does Entereg come in?
Entereg is currently marketed as capsule, per the FDA's National Drug Code Directory.
What class of drug is Entereg?
Entereg is classified as opioid antagonist, per the FDA's Established Pharmacologic Class.
Is Entereg FDA-registered?
Entereg is on record with the U.S. FDA under application number NDA021775. You can verify this on its official FDA label.
Has Entereg been recalled by the FDA?
Entereg has no FDA recalls recorded under its own application in the openFDA enforcement database. Its recall-safety score reflects its manufacturer's overall recall record. This is general reference, not medical advice — check the FDA recall database for the latest alerts.
Is Entereg safe?
There's no single safe-or-not verdict. pharmaranks gives Entereg a recall-safety score of 72/100, based on its FDA recall history (no recalls under its own FDA application) — not an efficacy or side-effect rating. Review its FDA-label side effects and warnings before use, and always consult a licensed professional.

Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.

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