ENTEREG vs NALOXONE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. ENTEREG and NALOXONE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ENTEREG	NALOXONE
Rating	72/100	72/100
Pharmacy pays	—	$4.41 /mL
Type	RX	RX
Active ingredient	ALVIMOPAN	NALOXONE HYDROCHLORIDE
Manufacturer	Cubist Pharms LLC	Hikma
Dosage forms	Capsule	Injectable
Drug class	Opioid Antagonist	Opioid Antagonist
Boxed warning	None	None
Half-life	—	30 to 81 minutes (mean 64 ± 12 minutes)
Treats	—	Opioid-Related Disorders, Respiration Disorders, Septic Shock

entereg naloxone

Rating

72/100

Pharmacy pays

—

$4.41 /mL

Type

Active ingredient

ALVIMOPAN

NALOXONE HYDROCHLORIDE

Manufacturer

Cubist Pharms LLC

Hikma

Dosage forms

Capsule

Injectable

Drug class

Opioid Antagonist

Boxed warning

None

Half-life

—

30 to 81 minutes (mean 64 ± 12 minutes)

Treats

—

Opioid-Related Disorders, Respiration Disorders, Septic Shock

Frequently asked questions

Which is better-rated, Entereg or Naloxone?

Entereg and Naloxone are tied at 3.6 out of 5 by our independent rating.

What is the difference between Entereg and Naloxone?

Entereg contains Alvimopan, while Naloxone contains Naloxone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.