desyrel

How long does Trazodone Hydrochloride stay in your body?

The elimination half-life of trazodone hydrochloride is about 7 hours (roughly 5 to 9 hours for the slower elimination phase) — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. Trazodone leaves the body in two phases: a faster early phase of about 3 to 6 hours and a slower phase of about 5 to 9 hours, with the parent drug's elimination half-life reported as about 7 hours. The liver (CYP3A4) breaks it into an active metabolite, m-chlorophenylpiperazine (mCPP), which can build up; clearance varies widely between people and is slowed by strong CYP3A4 inhibitors (e.g., ritonavir roughly doubled trazodone's half-life) and in older adults or those with liver impairment. Extended-release forms have a longer half-life (around 9 to 13 hours).

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: FDA Clinical Review, NDA 22-411 (trazodone), Pharmacokinetics — parent-drug elimination half-life ~7.1 h; biphasic 3–6 h / 5–9 h.

Frequently asked questions

What does Desyrel treat?

Desyrel (Trazodone Hydrochloride) may be used to treat depressive disorder, sleep initiation and maintenance disorders, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.

How does Desyrel work?

Desyrel is a serotonin reuptake inhibitor. Selective serotonin reuptake inhibitors (SSRIs) block the transporter that pulls serotonin back into nerve cells, so more of this mood-related chemical stays in the gaps between neurons to keep signaling. They act mainly on serotonin, which tends to mean fewer side effects than older antidepressants.

How much does Desyrel cost?

Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $1.52 for 30, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins. Pharmacies pay less for a same-class option, Sertraline Hydrochloride — about $1.09 on the same basis.

Is there a coupon or discount for Desyrel?

pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Desyrel. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.

Who makes Desyrel?

Desyrel is marketed by Pragma. You can see Pragma's full profile, rating, and other products on pharmaranks.

Is Desyrel a brand-name or generic drug?

Desyrel is a brand-name product with the active ingredient Trazodone Hydrochloride. Lower-cost generic equivalents containing Trazodone Hydrochloride are available — ask your pharmacist.

Is Desyrel available over the counter?

No. Desyrel is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.

What forms does Desyrel come in?

Desyrel is currently marketed as tablet, per the FDA's National Drug Code Directory.

What class of drug is Desyrel?

Desyrel is classified as serotonin reuptake inhibitor, per the FDA's Established Pharmacologic Class.

Is Desyrel FDA-registered?

Desyrel is on record with the U.S. FDA under application number NDA018207. You can verify this on its official FDA label.