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ciloxan

Pharmaranks rates Ciloxan 3.4/5 for recall safety — an independent score from its FDA recall history and its manufacturer's record. Ciloxan (Ciprofloxacin Hydrochloride) is a fluoroquinolone antibacterial used to treat Anthrax, Infectious Arthritis, Bacteroides Infections, Campylobacter Infections.

Ciprofloxacin Hydrochloride · by Sandoz

Available as a generic: Ciprofloxacin Hydrochloride

68/100Limited · 1 source

Based on 1 source · Recall-safety score from FDA recall history — this product's own recalls and its manufacturer's record. Not an efficacy or quality rating. methodology →

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate
Verified againstopenFDANIH DailyMedRxClass

Key facts

Form
Topical
Strength
Ciprofloxacin Hydrochloride EQ 0.3% Base
Type
Prescription (Rx)
Brand or generic
Brand-name
Manufacturer
Sandoz
Half-life
about 4 hours (how long it stays in your system)
What the pharmacy pays
~$3.74 for 30 — not your price
FDA application
NDA020369

What is Ciloxan?

From the FDA label:CILOXAN ® (ciprofloxacin ophthalmic ointment) 0.3% is a synthetic, sterile, multiple dose, antimicrobial for topical use. Ciprofloxacin is a fluoroquinolone antibacterial. It is available as the monohydrochloride monohydrate salt of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid. Ciprofloxacin is a faint to light yellow crystalline powder with a molecular weight of 385.82 g/mol. Its empirical formula is C 17 H 18 FN 3 O 3 •HCl•H 2 O and its chemical structure is as follows: Ciprofloxacin differs from other quinolones in that it has a fluorine atom at the 6-position, a piperazine moiety at the 7-position, and a cyclopropyl ring at the 1-position. Each gram of CILOXAN ® (ciprofloxacin ophthalmic ointment) 0.3% contains: Active: ciprofloxacin HCl 3.33 mg equivalent to 3 mg base. Inactives: mineral oil, white petrolatum. chemical structure

How to use

Apply a ½ inch ribbon into the conjunctival sac three times a day on the first two days, then apply a ½ inch ribbon two times a day for the next five days.

Side effects

The following adverse reactions (incidences) were reported in 2% of the patients in clinical studies for CILOXAN ® (ciprofloxacin ophthalmic ointment) 0.3%: discomfort and keratopathy. Other reactions associated with ciprofloxacin therapy occurring in less than 1% of patients included allergic reactions, blurred vision, corneal staining, decreased visual acuity, dry eye, edema, epitheliopathy, eye pain, foreign body sensation, hyperemia, irritation, keratoconjunctivitis, lid erythema, lid margin hyperemia, photophobia, pruritus, and tearing. Systemic adverse reactions related to ciprofloxacin therapy occurred at an incidence below 1% and included dermatitis, nausea and taste perversion.

Warnings

Important safety information

Serious and occasionally fatal hypersensitivity (anaphylactic) reactions, some following the first dose, have been reported in patients receiving systemic quinolone therapy. Some reactions were accompanied by cardiovascular collapse, loss of consciousness, tingling, pharyngeal or facial edema, dyspnea, urticaria, and itching. Only a few patients had a history of hypersensitivity reactions. Serious anaphylactic reactions require immediate emergency treatment with epinephrine and other resuscitation measures, including oxygen, intravenous fluids, intravenous antihistamines, corticosteroids, pressor amines, and airway management, as clinically indicated.

Who should not take Ciloxan

A history of hypersensitivity to ciprofloxacin or any other component of the medication is a contraindication to its use. A history of hypersensitivity to other quinolones may also contraindicate the use of ciprofloxacin.

Interactions

Specific drug interaction studies have not been conducted with ophthalmic ciprofloxacin. However, the systemic administration of some quinolones has been shown to elevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, enhance the effects of the oral anticoagulant, warfarin, and its derivatives, and has been associated with transient elevations in serum creatinine in patients receiving cyclosporine concomitantly.

Foods & drinks to be careful with

Well-established interactions for this medicine’s drug class, summarized from public health authorities. General information, not medical advice — always confirm with your pharmacist or the label.

How long does Ciprofloxacin Hydrochloride stay in your body?

The elimination half-life of ciprofloxacin hydrochloride is about 4 hours — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. This is the serum elimination half-life in adults with normal kidney function; it is slightly longer when kidney function is reduced and about 20% longer in older adults, and no metabolite has a materially longer half-life.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: CIPROFLOXACIN HYDROCHLORIDE tablet - DailyMed (FDA label).

Drug class

May treat (source: NIH RxClass)

See how Ciloxan ranks — best-rated fluoroquinolone antibacterial for:

Dosage forms

Topical

The forms currently marketed in the U.S., per the FDA National Drug Code Directory.

Ways to save

Ask for the generic

Same active ingredient, far cheaper. Is there a generic? →

Request a 90-day supply

Bulk fills usually lower the per-dose price vs monthly refills.

Use copay cards

Manufacturer copay cards & patient-assistance programs — especially for brand drugs.

Compare alternatives

A same-class option may cost less. See alternatives →

Frequently asked questions

What does Ciloxan treat?
Ciloxan (Ciprofloxacin Hydrochloride) may be used to treat anthrax, infectious arthritis, bacteroides infections, campylobacter infections, bacterial conjunctivitis, cystitis, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
How is Ciloxan rated?
pharmaranks gives Ciloxan a composite score of 3.4 out of 5, currently based on 1 weighted source (FDA regulatory recall-safety data weighted highest). See our methodology at /how-we-rate.
How much does Ciloxan cost?
Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $3.74 for 30, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.
Is there a coupon or discount for Ciloxan?
pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Ciloxan. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
Who makes Ciloxan?
Ciloxan is marketed by Sandoz. You can see Sandoz's full profile, rating, and other products on pharmaranks.
Is Ciloxan a brand-name or generic drug?
Ciloxan is a brand-name product with the active ingredient Ciprofloxacin Hydrochloride. Lower-cost generic equivalents containing Ciprofloxacin Hydrochloride are available — ask your pharmacist.
Is Ciloxan available over the counter?
No. Ciloxan is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
What forms does Ciloxan come in?
Ciloxan is currently marketed as topical, per the FDA's National Drug Code Directory.
What class of drug is Ciloxan?
Ciloxan is classified as fluoroquinolone antibacterial, quinolone antimicrobial, per the FDA's Established Pharmacologic Class.
Is Ciloxan FDA-registered?
Ciloxan is on record with the U.S. FDA under application number NDA020369. You can verify this on its official FDA label.
Has Ciloxan been recalled by the FDA?
Ciloxan has no FDA recalls recorded under its own application in the openFDA enforcement database. Its recall-safety score reflects its manufacturer's overall recall record. This is general reference, not medical advice — check the FDA recall database for the latest alerts.
Is Ciloxan safe?
There's no single safe-or-not verdict. pharmaranks gives Ciloxan a recall-safety score of 68/100, based on its FDA recall history (no recalls under its own FDA application) — not an efficacy or side-effect rating. Review its FDA-label side effects and warnings before use, and always consult a licensed professional.
What are the side effects of Ciloxan?
Ciloxan's side effects are taken directly from its FDA label. From the label: The following adverse reactions (incidences) were reported in 2% of the patients in clinical studies for CILOXAN ® (ciprofloxacin ophthalmic ointment) 0.3%: discomfort and keratopathy.… Both common and serious reactions are documented in full on this page. This is general reference from the FDA, not medical advice — always consult a professional.

Clinical content sourced from the FDA label via openFDA (U.S. FDA). View the FDA label on DailyMed → Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.

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