Ciprofloxacin is a fluoroquinolone antibacterial sold in the U.S. under 8 brand and generic names, for bacterial conjunctivitis, anthrax and infectious arthritis. Below: what the FDA label says, every product that contains it, what the pills look like, and its recall record.
From the FDA label for Ciloxan (application NDA020369). Other ciprofloxacin products — different forms, different strengths — are dosed differently. Follow the label for the one you were prescribed.
Apply a ½ inch ribbon into the conjunctival sac three times a day on the first two days, then apply a ½ inch ribbon two times a day for the next five days.
The following adverse reactions (incidences) were reported in 2% of the patients in clinical studies for CILOXAN ® (ciprofloxacin ophthalmic ointment) 0.3%: discomfort and keratopathy. Other reactions associated with ciprofloxacin therapy occurring in less than 1% of patients included allergic reactions, blurred vision, corneal staining, decreased visual acuity, dry eye, edema, epitheliopathy, eye pain, foreign body sensation, hyperemia, irritation, keratoconjunctivitis, lid erythema, lid margin hyperemia, photophobia, pruritus, and tearing. Systemic adverse reactions related to ciprofloxacin therapy occurred at an incidence below 1% and included dermatitis, nausea and taste perversion.
A history of hypersensitivity to ciprofloxacin or any other component of the medication is a contraindication to its use. A history of hypersensitivity to other quinolones may also contraindicate the use of ciprofloxacin.
Specific drug interaction studies have not been conducted with ophthalmic ciprofloxacin. However, the systemic administration of some quinolones has been shown to elevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, enhance the effects of the oral anticoagulant, warfarin, and its derivatives, and has been associated with transient elevations in serum creatinine in patients receiving cyclosporine concomitantly.
Dairy, calcium, iron & antacids
Separate the antibiotic from dairy, supplements, and antacids by a couple of hours — take it at the interval the label or your pharmacist specifies.
Tetracycline — MedlinePlus (U.S. National Library of Medicine) ↗Same active ingredient — different manufacturer, form, price and FDA recall record. That last one is what our independent score measures.
| # | Drug | Rating | Type | Form | Generic? | Typical price | |
|---|---|---|---|---|---|---|---|
| 1 | 64/100 | Prescription | Topical | Generic | $4 | View → | |
| 2 |
Imprint codes, colour and shape from the FDA’s labelling data. Match the imprint on your pill — or search any imprint.
| Imprint | Strength | Colour | Shape | Maker |
|---|---|---|---|---|
| L54 | 500 mg | white | capsule | — |
| Y102 | 500 mg | white | oval | — |
| E451 | 500 mg | white | oval | — |
| L54 | 500 mg | white | capsule | — |
| L53 | 250 mg | white | round | — |
| L54 | 500 mg | white |
A combination is a different drug — different dosing, different warnings. It is listed here so you can find it, not so you can substitute it.
From the FDA Enforcement database. A recall covers specific lots — not the drug as a whole.
Ciprofloxacin 0.3% and Dexamethasone 0.1% Otic Suspension Rx Only
Temperature Abuse
Sandoz Inc · Aug 13, 2025
Ciprofloxacin Ophthalmic Solution USP
Defective container: Unable to get the solution out of the bottle as the spike of the cap was lodged in the nozzle of the product bottle
FDC Limited · Mar 11, 2025
CIPROFLOXACIN OPHTH SOLUTION
Defective Container: Unable to get the solution out of the bottle as the spike of the cap was lodged in the nozzle of the product bottle
Direct Rx · Jan 31, 2025
Ciprofloxacin Ophthalmic Solution USP
Defective container: Unable to get the solution out of the bottle as the spike of the cap was lodged in the nozzle of the product bottle
FDC Limited · Dec 16, 2024
Ciprofloxacin ophthalmic solution USP
Defective container: unable to get the solution out of the bottle as the spike of the cap was lodged in the nozzle of the product bottle.
FDC Limited · Jul 23, 2024
The elimination half-life of ciprofloxacin is about 4 hours. This is the serum elimination half-life in adults with normal kidney function; it is slightly longer when kidney function is reduced and about 20% longer in older adults, and no metabolite has a materially longer half-life.
CIPROFLOXACIN HYDROCHLORIDE tablet - DailyMed (FDA label) ↗Half-life is how long the body takes to clear half a dose. It is not the same as how long a drug test can detect it, and it varies with age, kidney and liver function.
Sources: FDA openFDA drug label, National Drug Code Directory, and Enforcement (recall) database. This page reproduces public FDA data and is not medical advice. Dosing is set by your prescriber.
| 46/100 |
| Prescription |
| Injectable |
| Generic |
| $4 |
| View → |
| 3 | Not yet rated | Prescription | Drops | Generic | $4 | View → |
| 4 | Not yet rated | Prescription | Injectable | Generic | $4 | View → |
| 5 | Not yet rated | Prescription | Injectable | Generic | $4 | View → |
| 6 | Not yet rated | Prescription | Solution | Generic | $4 | View → |
| 7 | Not yet rated | Prescription | Injectable | Generic | $4 | View → |
| 8 | Not yet rated | Prescription | Tablet | Generic | $4 | View → |
| capsule |
| — |
| C;93 | 750 mg | white | capsule | — |
|---|
| C;94 | 500 mg | white | capsule | — |
|---|