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butalbital, aspirin and caffeine

Butalbital, Aspirin and Caffeine is a combination medicine containing Aspirin, Butalbital, and Caffeine.

Aspirin and Butalbital and Caffeine · by Quantum Pharmics

Generic of Fiorinal

Not yet rated· sourced from the FDA label
Rated against independent regulatory sources·Last updated June 7, 2026·How we rate
Verified againstopenFDANIH DailyMedRxClass

Key facts

Active ingredient
Aspirin and Butalbital and Caffeine
Form
Tablet
Strength
Aspirin 325MG; Butalbital 50MG; Caffeine 40MG
Type
Prescription (Rx)
Brand or generic
Generic
Manufacturer
Quantum Pharmics
Half-life
about 20 minutes (the label also states 0.33 hours) for aspirin itself (how long it stays in your system)
What the pharmacy pays
~$0.78 for 30 — not your price
FDA application
ANDA088972
Availability
Discontinued (per FDA)

How long does Aspirin and Butalbital and Caffeine stay in your body?

The elimination half-life of aspirin and butalbital and caffeine is about 20 minutes (the label also states 0.33 hours) for aspirin itself — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. Aspirin's own half-life is misleadingly short: the label says aspirin "is rapidly hydrolyzed in plasma to salicylic acid, with a half-life of 20 minutes," so aspirin behaves essentially as a prodrug and salicylic acid is the active moiety that persists. The label gives salicylic acid a half-life of 1.71 hours at these doses, "correspond[ing] well with data from the literature at lower doses which state a resultant half-life of approximately 2 to 3 hours." Salicylate elimination is saturable: "at higher doses, the elimination of salicylic acid follows zero-order kinetics... with an apparent half-life of 6 hours or higher," and "following toxic doses (10 to 20 g), the plasma half-life may be increased to over 20 hours." Renal clearance of free salicylate is urine-pH dependent (rising from <5% to >80% as urinary pH goes above 6.5). This label does not quantify a half-life change by age; for organ impairment it does not give altered half-life numbers but instructs that aspirin be avoided in severe renal failure (GFR <10 mL/min) and in severe hepatic insufficiency. Note also that aspirin's antiplatelet effect far outlasts both half-lives, because it irreversibly acetylates platelet COX-1 for the platelet's lifespan — half-life does not predict duration of effect here. Half-life figures are pharmacokinetic, not a drug-test detection window and not dosing guidance.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: DailyMed — ASPIRIN AND EXTENDED-RELEASE DIPYRIDAMOLE capsule, extended release (Clinical Pharmacology / Pharmacokinetics: Aspirin).

Dosage forms

Tablet

The forms currently marketed in the U.S., per the FDA National Drug Code Directory.

Ways to save

Ask for the generic

Same active ingredient, far cheaper. Is there a generic? →

Request a 90-day supply

Bulk fills usually lower the per-dose price vs monthly refills.

Use copay cards

Manufacturer copay cards & patient-assistance programs — especially for brand drugs.

Compare alternatives

A same-class option may cost less. See alternatives →

Frequently asked questions

How much does Butalbital, Aspirin and Caffeine cost?
Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $0.78 for 30, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.
Is there a coupon or discount for Butalbital, Aspirin and Caffeine?
pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Butalbital, Aspirin and Caffeine. To pay less, Butalbital, Aspirin and Caffeine is already a generic — usually the lowest-cost version — so the main levers are comparing cash prices between pharmacies and using a pharmacy discount-card service. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
Who makes Butalbital, Aspirin and Caffeine?
Butalbital, Aspirin and Caffeine is marketed by Quantum Pharmics. You can see Quantum Pharmics's full profile, rating, and other products on pharmaranks.
Is Butalbital, Aspirin and Caffeine a brand-name or generic drug?
Butalbital, Aspirin and Caffeine is a generic medication; its active ingredient is Aspirin and Butalbital and Caffeine. Generics contain the same active ingredient as the brand-name original and are usually lower cost.
Is Butalbital, Aspirin and Caffeine available over the counter?
No. Butalbital, Aspirin and Caffeine is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
What forms does Butalbital, Aspirin and Caffeine come in?
Butalbital, Aspirin and Caffeine is currently marketed as tablet, per the FDA's National Drug Code Directory.
Is Butalbital, Aspirin and Caffeine FDA-registered?
Butalbital, Aspirin and Caffeine is on record with the U.S. FDA under application number ANDA088972. You can verify this on its official FDA label.

Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.

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