BUTALBITAL, ASPIRIN AND CAFFEINE vs COLAZAL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 7, 2026·How we rate

Possible drug interaction. BUTALBITAL, ASPIRIN AND CAFFEINE and COLAZAL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	BUTALBITAL, ASPIRIN AND CAFFEINE	COLAZAL
Rating	New	74/100
Pharmacy pays	~$0.78 /30	~$11.02 /30
Type	RX	RX
Active ingredient	ASPIRIN AND BUTALBITAL AND CAFFEINE	BALSALAZIDE DISODIUM
Manufacturer	Quantum Pharmics	Valeant Pharm Intl
Dosage forms	Tablet	Capsule
Drug class	—	Aminosalicylate
Boxed warning	None	None
Half-life	about 20 minutes (the label also states 0.33 hours) for aspirin itself	—
Treats	—	Ulcerative Colitis

butalbital, aspirin and caffeine colazal

Rating

New

74/100

Pharmacy pays

~$0.78 /30

~$11.02 /30

Type

Active ingredient

ASPIRIN AND BUTALBITAL AND CAFFEINE

BALSALAZIDE DISODIUM

Manufacturer

Quantum Pharmics

Valeant Pharm Intl

Dosage forms

Tablet

Capsule

Drug class

—

Aminosalicylate

Boxed warning

None

Half-life

about 20 minutes (the label also states 0.33 hours) for aspirin itself

—

Treats

—

Ulcerative Colitis

Frequently asked questions

Which is cheaper, Butalbital, Aspirin and Caffeine or Colazal?

Butalbital, Aspirin and Caffeine costs pharmacies less to acquire — about $0.78 vs $11.02 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Butalbital, Aspirin and Caffeine and Colazal?

Butalbital, Aspirin and Caffeine contains Aspirin and Butalbital and Caffeine, while Colazal contains Balsalazide Disodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.