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Best treatments for infectious skin diseases

20 products may treat infectious skin diseases, spanning FDA drug classes such as macrolide antimicrobial, aminoglycoside antibacterial, lipoglycopeptide antibacterial. The current highest-rated option is dalvance. Ranked below by our independent recall-safety rating (rated where FDA data exists) — not medical advice; always consult a professional.

Quick answer: Of the 20 drugs we list for infectious skin diseases, 8 are available as lower-cost generics, spanning classes such as macrolide antimicrobial, aminoglycoside antibacterial, lipoglycopeptide antibacterial. They’re ranked by each drug’s FDA recall-safety record — not clinical effectiveness for infectious skin diseases — so confirm the right choice with your prescriber.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Understanding infectious skin diseases

"Skin Diseases, Infectious" is a category, not a single illness — it is the umbrella term for any infection of the skin itself. MedlinePlus (NLM) organizes the group by the germ responsible: "Bacteria cause cellulitis, impetigo, and staphylococcal (staph) infections," "Viruses cause shingles, warts, and herpes simplex," "Fungi cause athlete's foot and yeast infections," and "Parasites cause body lice, head lice, and scabies." Which of those four it is decides everything downstream, because an antibiotic does nothing against a fungus. Two things people commonly get wrong here. First, ringworm is not a worm. MedlinePlus states plainly that "Tinea is the name of a group of diseases caused by a fungus" and that "a worm doesn't cause it" — the ring-shaped rash is fungal, and scalp ringworm, per MedlinePlus, "usually affects children." Second, cellulitis is a clinical judgment, not a lab finding. StatPearls (NCBI Bookshelf) states that cellulitis "is most often unilateral and rarely (if ever) presents bilaterally," and describes chronic venous stasis dermatitis — a long-standing, bilateral, non-infectious dermatosis of the inner ankles (medial malleoli), with scaling and hyperpigmentation — as a look-alike. So redness and swelling in both legs at once points away from cellulitis, and toward one of its mimics. This is general health information, not medical advice; talk to a clinician about your own situation.

First-line treatment

The 2014 Infectious Diseases Society of America (IDSA) guideline on skin and soft tissue infections sorts bacterial cases first by whether there is pus: purulent (abscesses, furuncles, carbuncles) versus nonpurulent (cellulitis and erysipelas). For a pus-filled lesion, IDSA states that "Incision and drainage is the recommended treatment for inflamed epidermoid cysts, carbuncles, abscesses, and large furuncles" (strong recommendation, high-quality evidence) — the procedure, not a prescription, is the treatment. For nonpurulent cellulitis the guideline directs empiric therapy at streptococci, naming penicillin and the cephalosporins; the agents used against MRSA, such as trimethoprim-sulfamethoxazole and doxycycline, sit on the purulent/MRSA side of that split. IDSA also states that in typical cellulitis "Cultures of blood or cutaneous aspirates, biopsies, or swabs are not routinely recommended" (strong, moderate) — so an ordinary work-up yields no laboratory confirmation at all, which is why the exam matters so much. Fungal tinea runs on a separate track: MedlinePlus (NLM) says over-the-counter creams and powders "will get rid of many tinea infections, particularly athlete's foot and jock itch," and that "Other cases require prescription medicine."

Top-rated picks for infectious skin diseases: 1. Dalvance · 2. Teflaro · 3. Azasite

Top-rated treatments for infectious skin diseases, ranked by pharmaranks score
#DrugRatingPharmacy pays
172/100View →
272/100View →
370/100$9View →
470/100$1View →
570/100View →
670/100View →
770/100View →
870/100$1View →
970/100$1View →
1068/100$1View →

Full ranking · 20 treatments

ABBVIE logo

dalvance

PrescriptionFDA-sourced

72/100

Dalvance (Dalbavancin Hydrochloride) is a medication used to treat Infectious Skin Diseases, Staphylococcal Infections, Streptococcal Infections.

(6 data points)
skin diseases, infectiousstaphylococcal infectionsstreptococcal infections

Price varies

View details →
ABBVIE logo

teflaro

PrescriptionFDA-sourced

72/100

Teflaro (Ceftaroline Fosamil) is a medication used to treat Escherichia Coli Infections, Klebsiella Infections, Pneumonia, Infectious Skin Diseases.

(6 data points)
escherichia coli infectionsklebsiella infectionspneumonia

Price varies

View details →
THEA PHARMA logo
#3 of 4 in Macrolide Antimicrobial

azasite

PrescriptionFDA-sourced

70/100

Azasite (Azithromycin) is a macrolide antimicrobial used to treat Chlamydia Infections, Haemophilus Infections, Nontuberculous Mycobacterium Infections, Otitis Media.

(2 data points)
macrolide antimicrobialchlamydia infectionshaemophilus infections

Pharmacy pays

From ~$7.03/30· 6 forms
View details →
#1 of 8 in Aminoglycoside Antibacterial

bethkis

PrescriptionFDA-sourced

70/100

Bethkis (Tobramycin) is an aminoglycoside antibacterial used to treat Infectious Bone Diseases, Central Nervous System Infections, Pseudomonas Infections, Respiratory Tract Infections.

(2 data points)
aminoglycoside antibacterialbone diseases, infectiouscentral nervous system infections

Pharmacy pays

From ~$0.65· 4 forms
View details →

chg scrub

Over-the-counterFDA-sourced

70/100

Chg Scrub (Chlorhexidine Gluconate) is a medication used to treat Oral Candidiasis, Periodontal Diseases, Infectious Skin Diseases, Gram-Negative Bacterial Infections.

(5 data points)
candidiasis, oralperiodontal diseasesskin diseases, infectious
Available online
View details →
BECTON DICKINSON CO logo

chlorhexidine gluconate

Over-the-counterFDA-sourced

70/100

Chlorhexidine Gluconate is a medication used to treat Oral Candidiasis, Periodontal Diseases, Infectious Skin Diseases, Gram-Negative Bacterial Infections.

(1 data points)
candidiasis, oralperiodontal diseasesskin diseases, infectious
Available online
View details →

Frequently asked

What treats infectious skin diseases?
Our catalog lists 20 products that may treat infectious skin diseases, based on NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. They're rated where FDA recall-safety data exists; the current top-rated option is dalvance.
What is the best-rated treatment for infectious skin diseases?
By our independent recall-safety rating — not an efficacy measure — dalvance ranks highest among the products we list for infectious skin diseases. Always consult a professional.
How are these treatments ranked?
By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.
What types of drugs treat infectious skin diseases?
Treatments for infectious skin diseases span FDA drug classes including macrolide antimicrobial, aminoglycoside antibacterial, lipoglycopeptide antibacterial. Compare every option side by side, ranked by independent rating, above.

Treatment associations are derived from NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. This is general reference, not medical advice — always consult a licensed professional.

Sources

The clinical overview above is written from these authoritative public-health and medical-society sources, independently reviewed against each.